NADH-quinone oxidoreductase subunit G - Blochmannia floridanus

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit G
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit G
    NDH-1 subunit G
    NUO7

Gene names

Name:	nuoG
Ordered Locus Names:	Bfl488

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

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Protein attributes

Sequence length	941 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD⁺ + quinol.
Cofactor	Binds 1 2Fe-2S cluster per subunit By similarity. Binds 3 4Fe-4S clusters per subunit By similarity.
Subunit structure	Composed of 13 different subunits. Subunits nuoCD, E, F, and G constitute the peripheral sector of the complex.
Sequence similarities	Belongs to the complex I 75 kDa subunit family. Contains 1 2Fe-2S ferredoxin-type domain.

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Ontologies

Keywords
Ligand	2Fe-2S 4Fe-4S Iron Iron-sulfur Metal-binding NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 941

941

NADH-quinone oxidoreductase subunit G

PRO_0000118545

Regions

Domain

1 – 91

91

2Fe-2S ferredoxin-type

Sites

Metal binding

35

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

46

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

49

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

75

1

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

107

1

Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity

Metal binding

111

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

114

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

120

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

159

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

162

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

165

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

209

1

Iron-sulfur 3 (4Fe-4S) By similarity

Metal binding

236

1

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

239

1

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

243

1

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

271

1

Iron-sulfur 4 (4Fe-4S) Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q7VRV7-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: A374A629B6E6FF72
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FASTA

941

107,295

        10         20         30         40         50         60 
MMIPIYIEEK KYMVEDTKNV LEVCLSLGFN VPYFCWHPAL GSIGSCRQCA VKLYDNLHCV 

        70         80         90        100        110        120 
PDSKHINFGR LVMSCMTPVI KDMYISLFDK ELQEFRKNIL ELLMVNHPHD CPVCEEGGNC 

       130        140        150        160        170        180 
HLQDMAVMVE HTYRRYRFTK RTHYNQYLGP FITHEMNRCI TCYRCVRYYK DYAGGNDLGV 

       190        200        210        220        230        240 
FGVHDNIYFG RVQDGILQSE FSGNLVEICP TGVFTDKTQS KNYARKWDIT FAPSICHQCS 

       250        260        270        280        290        300 
VGCNIILGER YGKLCRVENR YNSKVNGYFL CDRGRFGCNY IHIKNRPQKL LKKQNNCGYI 

       310        320        330        340        350        360 
EINAVDAVQD CVNILKSSNK IIGIGSTRAS IESNFALRNL VGADNFYSGM SFFEQERLSL 

       370        380        390        400        410        420 
IFEILRNSGI YIPSVCDIEN YDAILILGED VTQTSARIAL AIRQAVRSKS DHMAKYVGIY 

       430        440        450        460        470        480 
KWQSLAVTNF AQDAKYPLFI TGIDKTKLDD IAMYTYYDSV QNQARFGFSI AYAVDNQVSF 

       490        500        510        520        530        540 
VKDFNLNGLD ITKLDLVVEK LMCARKPLIV SGSNSGSKEL IIAAVNIAYA LKRKKSDVGL 

       550        560        570        580        590        600 
VLVDHDVNSI GLSMMTSKSV DDVFNTLSDT NNGNAVFNTV IILENDLYRH ASVAKINKML 

       610        620        630        640        650        660 
SNINYLIVLD HQYNIIQDKA DLIFPVSSFA ESDGTVINYE GRAQRFFKLY NPQNYDKNSD 

       670        680        690        700        710        720 
ILESWKWLYL IHDTYVNCTR VKAVNIDYII DSIACCFPEL KKIKYASPKS NFRVHGQKLA 

       730        740        750        760        770        780 
QSTHRYSGRT SINANVNVHE TSTPINDNTM FTFSMEGNSG NYSKKCSYNQ IPFVWAPGWN 

       790        800        810        820        830        840 
SPQAWNKFQD QIGGNLYPSD PGVLLFDTGQ ENKCIDDNLY KSINWLKFAS NSLNISKYTN 

       850        860        870        880        890        900 
KWIVAPYWHL FGSEETSQNV ECIKNCMLNP YAMLNILDAK YINIQENMYI KFTCMDQVLC 

       910        920        930        940 
LPVKFSMDLP KKHIGLPMGF PGIPVFFSGM YVSNIEMMEA P

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References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes."
Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases
	BX248583 Genomic DNA. Translation: CAD83177.1.
RefSeq	NP_878771.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1499688.
GenomeReviews	Gene locus Bfl488 in contig BX248583_GR.
KEGG	bfl:Bfl488.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VRV7.
OMA	Q7VRV7. WVEVSWE.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL488-MON.
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR001041. Ferredoxin. IPR006963. Mopterin_OxRdtase_Fe4S4. IPR000283. NADH_UbQ_OxRdtase_75KDa_su_CS. IPR010228. NADH_UbQ_OxRdtase_Gsu. IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd. [Graphical view]
Pfam	PF00111. Fer2. 1 hit. PF04879. Molybdop_Fe4S4. 1 hit. PF10588. NADH-G_4Fe-4S_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01973. NuoG. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. False negative. PS51085. 2FE2S_FER_2. 1 hit. PS00641. COMPLEX1_75K_1. 1 hit. PS00642. COMPLEX1_75K_2. 1 hit. PS00643. COMPLEX1_75K_3. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

NUOG_BLOFL

Accession

Primary (citable) accession number: Q7VRV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents