Reviewed, UniProtKB/Swiss-Prot Q7VRN2 (AROK_BLOFL)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	Bfl572

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity.
Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the shikimate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Shikimate kinase HAMAP MF_00109		PRO_0000237847
Regions
	Nucleotide binding	15 – 20	6	ATP By similarity
Sites
	Metal binding	19	1	Magnesium By similarity
	Binding site	37	1	Substrate By similarity
	Binding site	61	1	Substrate By similarity
	Binding site	83	1	Substrate; via amide nitrogen By similarity
	Binding site	121	1	ATP By similarity
	Binding site	146	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VRN2-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: C38893963DCCA9DC	FASTA	185	21,130
	10 20 30 40 50 60 MLTDNRKIFL IGPMGAGKST IGRQLAQRLN LEFFDSDREI ETCTGVNISW VFDVEGEVGF 70 80 90 100 110 120 RNREEKIIDE LTQKKSIVLA TGGGSIKSHI ARDHLAKRGL VIYLKTTIDK QLVRTKRDKR 130 140 150 160 170 180 RPLLKSSTLF NYQNLRELLE DLAKERNPLY EEISDITVST DEYSVKCVVN KILVLLKKNG AIYKD

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83254.1.
RefSeq	NP_878847.1.
3D structure databases
HSSP	HSSP built from PDB template 1KAG based on UniProtKB P24167.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7VRN2.
Genome annotation databases
GeneID	1499772.
GenomeReviews	Gene locus Bfl572 in contig BX248583_GR.
KEGG	bfl:Bfl572.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VRN2.
OMA	HANVFFV.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL572-MON.
Family and domain databases
HAMAP	MF_00109. [Tree]
InterPro	IPR000623. Shik_kinase. [Graphical view]
Pfam	PF01202. SKI. 1 hit. [Graphical view]
PRINTS	PR01100. SHIKIMTKNASE.
PROSITE	PS01128. SHIKIMATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_BLOFL

Accession

Primary (citable) accession number: Q7VRN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)