Reviewed, UniProtKB/Swiss-Prot Q7VRM0 (ILVC_BLOFL)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	Bfl588

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Ketol-acid reductoisomerase		PRO_0000151298
Sites
	Active site	132	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VRM0-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 32B6EAAF8E90C47A	FASTA	492	55,697
	10 20 30 40 50 60 MNNYFNKLTF IQKIKHLGQC RLMKKNEFSD GVRALLSKKI VIIGCGSQGL NQGLNMRDSG 70 80 90 100 110 120 LNITYALRRD SIINQSQSYI RAMKYGFSVG TYDELIPEAD FVINLIPDKY HESLIQKIEP 130 140 150 160 170 180 LMKYKAVLGY SHGFHIVEIG VKIRQDITVI MVAPKCPGTE VRQEYQRGFG VPALIAVHEE 190 200 210 220 230 240 NNAYGTGMEL AKSWACSIGS NKAGVLESSF VAEVKSDLMG EQTVLCGMLQ VGSIFCFDKM 250 260 270 280 290 300 VEDGLDSGYA GKLVQNGWEV ITEALKQGGI TLMMDRLSNV SKLRAFELSD QLKNILTPVF 310 320 330 340 350 360 EKHMEDILDG SFSKNMMLDW INKDCKLLSY RQNNSQLLFE KAPVYCETIL EQTYFDHGVL 370 380 390 400 410 420 MVAIIKASVE LAFDIMVKSG IKPESAYYES LHELPLIANT IARKRLYEMN MVISDTAEYG 430 440 450 460 470 480 NYLFSDFVLP LLKKEFVPYL KRGDLDLSHV NNIVHIDNIL LRDINEMIRT HPIEKVGVQL 490 RSYMKDMVSL SF

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83266.1.
RefSeq	NP_878859.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1499788.
GenomeReviews	Gene locus Bfl588 in contig BX248583_GR.
KEGG	bfl:Bfl588.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VRM0.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL588-MON.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR014359. KetolA_reductoisomerase_bac. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
PIRSF	PIRSF000116. IlvC_gammaproteo. 1 hit.
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_BLOFL

Accession

Primary (citable) accession number: Q7VRM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 1, 2003
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)