Reviewed, UniProtKB/Swiss-Prot Q7VRH9 (DXS_BLOFL)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	Bfl238

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189097

Sequences

	Sequence		Length	Mass (Da)
	Q7VRH9-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 640BF822D24FB188	FASTA	617	68,722
	10 20 30 40 50 60 MSLKLNKYSI LELIDTPTEL RQLTENKLQT LCSELRLFLL NSVSKSSGHF ASGLGTIELT 70 80 90 100 110 120 VALHYVYNTP FDHLIWDVGH QAYPHKILTG RKNRIYSIRQ RHGLHSFPCR NESKYDVLSV 130 140 150 160 170 180 GHSSTSISAG LGLAIASERE KLNRRTVCII GDGALTAGMA FEAINHAGTI KSNLLIILND 190 200 210 220 230 240 NNMSISENVG ALHTQCPQQK KYTNITSDIK KIINSNIYNK NKNTSTAIAL FSNLGFNCTG 250 260 270 280 290 300 PIDGHNILTL IHNLKNIRNT KTGPQFLHVI TKKGYGYKPA EKDPIKWHAV PKFNLKSGIL 310 320 330 340 350 360 STNKNIKYTT YSKIFGDWLC QTAMHDNKII GITPAMREGS GMNKFAQKYP KQYFDVAIAE 370 380 390 400 410 420 QHAVTFSAGL AIAGYKPVVA IYSTFLQRAY DQIIHDIAIQ KLPVLFAVDR GGIVGSDGET 430 440 450 460 470 480 HQGAFDLSYL RCIPNLIIMT PSNAYECKLM LHTGYHYQYG PSVVRYPKGC ATNNILYPYN 490 500 510 520 530 540 NTTSLYSIPL SKGIIHHQGQ HIAILNFGTL LKPAYNVALQ LNATLVDMRF VKPLDEMLIK 550 560 570 580 590 600 KLTENHQAFI TLEENSIIGG AGSGVNEFLV QNKLLIPTLN IGLPDFFIPQ GAQREMLSEL 610 GLDSQGIYKK IVRWIKI

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83309.1.
RefSeq	NP_878535.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7VRH9.
Genome annotation databases
GeneID	1499438.
GenomeReviews	Gene locus Bfl238 in contig BX248583_GR.
KEGG	bfl:Bfl238.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VRH9.
OMA	MQELPHP.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL238-MON.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BLOFL

Accession

Primary (citable) accession number: Q7VRH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)