Q7VRG4 (SPEB_BLOFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Agmatinase
EC=3.5.3.11

Alternative name(s):
Agmatine ureohydrolase
Short name=AUH

Gene names

Name:	speB
Ordered Locus Names:	Bfl253

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › unclassified Enterobacteriaceae › ant, tsetse, mealybug, aphid, etc. endosymbionts › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of putrescine from agmatine By similarity. HAMAP-Rule MF_01418
Catalytic activity	Agmatine + H2O = putrescine + urea. HAMAP-Rule MF_01418
Cofactor	Manganese By similarity. HAMAP-Rule MF_01418
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	putrescine biosynthetic process Inferred from electronic annotation. Source: HAMAP spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	agmatinase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Agmatinase HAMAP-Rule MF_01418		PRO_0000173729
Sites
	Metal binding	126	1	Manganese By similarity
	Metal binding	149	1	Manganese By similarity
	Metal binding	151	1	Manganese By similarity
	Metal binding	153	1	Manganese By similarity
	Metal binding	230	1	Manganese By similarity
	Metal binding	232	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VRG4 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 441761E865D634C9	FASTA	303	34,254
	10 20 30 40 50 60 MCTLMHKHDD SLFSNSFGFL RLPLEFYPYT RHNDWVITGV PFDIATSGRS GSRFGPASIR 70 80 90 100 110 120 KASINLAWEN CRWPWNFDIR QKLKIIDCGD LIYKSGNVQD FTNILQKHIE NLLRFRKKIL 130 140 150 160 170 180 LLGGDHYITL PVLRAYSKFF GTISIIHFDA HADYYDNNNQ YDHGAVILYA LHEKLINPNR 190 200 210 220 230 240 SVQIGIRTEY DKNFGFTVLD AEYVNTTAVH VLINQIVSVI QNRPVYLTFD IDCLDPSVAP 250 260 270 280 290 300 GTGTPVIGGL TTSCALQIIR GFQKLNIIGI DIVEVAPVYD CAQITALAAA TLGLEMLYTQ VKF

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248583 Genomic DNA. Translation: CAD83324.1.
RefSeq	NP_878550.1. NC_005061.1.
3D structure databases
ProteinModelPortal	Q7VRG4.
ModBase	Search...
Protein-protein interaction databases
STRING	203907.Bfl253.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD83324; CAD83324; Bfl253.
GeneID	1499453.
KEGG	bfl:Bfl253.
PATRIC	31964101. VBICanBlo38691_0245.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0010.
HOGENOM	HOG000204320.
KO	K01480.
OMA	QIGIRTD.
ProtClustDB	PRK02190.
Enzyme and pathway databases
BioCyc	BFLO203907:GHF7-253-MONOMER.
Family and domain databases
Gene3D	3.40.800.10. 1 hit.
HAMAP	MF_01418. SpeB.
InterPro	IPR023694. Agmatinase. IPR005925. Agmatinase-rel. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
PANTHER	PTHR11358. PTHR11358. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
TIGRFAMs	TIGR01230. agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB_BLOFL

Accession

Primary (citable) accession number: Q7VRG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	October 1, 2003
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program