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Protein

Agmatinase

Gene

speB

Organism
Blochmannia floridanus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.By similarity

Catalytic activityi

Agmatine + H2O = putrescine + urea.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261ManganeseBy similarity
Metal bindingi149 – 1491ManganeseBy similarity
Metal bindingi151 – 1511ManganeseBy similarity
Metal bindingi153 – 1531ManganeseBy similarity
Metal bindingi230 – 2301ManganeseBy similarity
Metal bindingi232 – 2321ManganeseBy similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process Source: UniProtKB-HAMAP
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBFLO203907:GHF7-253-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:Bfl253
OrganismiBlochmannia floridanus
Taxonomic identifieri203907 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
ProteomesiUP000002192 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303AgmatinasePRO_0000173729Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203907.Bfl253.

Structurei

3D structure databases

ProteinModelPortaliQ7VRG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.Curated

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VRG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTLMHKHDD SLFSNSFGFL RLPLEFYPYT RHNDWVITGV PFDIATSGRS
60 70 80 90 100
GSRFGPASIR KASINLAWEN CRWPWNFDIR QKLKIIDCGD LIYKSGNVQD
110 120 130 140 150
FTNILQKHIE NLLRFRKKIL LLGGDHYITL PVLRAYSKFF GTISIIHFDA
160 170 180 190 200
HADYYDNNNQ YDHGAVILYA LHEKLINPNR SVQIGIRTEY DKNFGFTVLD
210 220 230 240 250
AEYVNTTAVH VLINQIVSVI QNRPVYLTFD IDCLDPSVAP GTGTPVIGGL
260 270 280 290 300
TTSCALQIIR GFQKLNIIGI DIVEVAPVYD CAQITALAAA TLGLEMLYTQ

VKF
Length:303
Mass (Da):34,254
Last modified:September 30, 2003 - v1
Checksum:i441761E865D634C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248583 Genomic DNA. Translation: CAD83324.1.
RefSeqiNP_878550.1. NC_005061.1.
WP_011126533.1. NC_005061.1.

Genome annotation databases

EnsemblBacteriaiCAD83324; CAD83324; Bfl253.
KEGGibfl:Bfl253.
PATRICi31964101. VBICanBlo38691_0245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248583 Genomic DNA. Translation: CAD83324.1.
RefSeqiNP_878550.1. NC_005061.1.
WP_011126533.1. NC_005061.1.

3D structure databases

ProteinModelPortaliQ7VRG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203907.Bfl253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD83324; CAD83324; Bfl253.
KEGGibfl:Bfl253.
PATRICi31964101. VBICanBlo38691_0245.

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Enzyme and pathway databases

BioCyciBFLO203907:GHF7-253-MONOMER.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSPEB_BLOFL
AccessioniPrimary (citable) accession number: Q7VRG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2004
Last sequence update: September 30, 2003
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.