Reviewed, UniProtKB/Swiss-Prot Q7VRE2 (DXR_BLOFL)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
      Short name=DXP reductoisomerase
    EC=1.1.1.267
Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomerase
    2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

Name:	dxr
Ordered Locus Names:	Bfl275

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.
Catalytic activity	2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183
Cofactor	Divalent cation By similarity.
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DXR family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Ligand	Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183		PRO_0000163617
Sites
	Metal binding	135	1	Divalent metal cation By similarity
	Metal binding	137	1	Divalent metal cation By similarity
	Metal binding	216	1	Divalent metal cation By similarity
	Binding site	110	1	Substrate By similarity
	Binding site	137	1	Substrate By similarity
	Binding site	171	1	Substrate By similarity
	Binding site	194	1	Substrate By similarity
	Binding site	216	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VRE2-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 52AC977F20C7AEB6	FASTA	391	44,186
	10 20 30 40 50 60 MISGAQQYRD KFAVRALVAH NDVAVMIEQC FLVSPQYVCM ICEEVARNLK YKLVLMDKNN 70 80 90 100 110 120 IQVLSGMKDA CVLSALDAVD MVVSTMAGIA RLQPIFSAIR VGKKILLANK ETLVLSGQLF 130 140 150 160 170 180 MTEVYKYNAS VLPLDSEYNA IFQNLSVIYQ KKLGQVSLSQ YGICCIVLTD SGGVLYKITR 190 200 210 220 230 240 TKLFKITPVQ VYIHPNWSMG LKISVNSATV MNRVLEYIEA HHLFNVSSNE IEILLHTQTI 250 260 270 280 290 300 IYATIRYSDG SVLAHFSTPD MKIFIAYAMA YLNKIKLNNI STYSKQYEIY NTYCGNNTLN 310 320 330 340 350 360 LDILDTKNYP CLQTAIDASN HSQDSVIVLN ADNEVTVEAF LCEMIAFIKI PNFIYRIMNT 370 380 390 LNHFQEPSTI DDIIYIDHCI KETEIRYAIG N

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83346.1.
RefSeq	NP_878572.1.
3D structure databases
HSSP	HSSP built from PDB template 1K5H based on UniProtKB P45568.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7VRE2.
Genome annotation databases
GeneID	1499475.
GenomeReviews	Gene locus Bfl275 in contig BX248583_GR.
KEGG	bfl:Bfl275.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VRE2.
OMA	NDIPATI.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL275-MON.
Family and domain databases
HAMAP	MF_00183. Divergent sequence. [Tree]
InterPro	IPR003821. DXP_reductoisomerase. IPR013644. DXP_reductoisomerase_C. IPR013512. DXP_reductoisomerase_N. [Graphical view]
Pfam	PF08436. DXP_redisom_C. 1 hit. PF02670. DXP_reductoisom. 1 hit. [Graphical view]
PIRSF	PIRSF006205. Dxp_reductismrs. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DXR_BLOFL

Accession

Primary (citable) accession number: Q7VRE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)