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Q7VRA6

- SYL_BLOFL

UniProt

Q7VRA6 - SYL_BLOFL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Blochmannia floridanus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei628 – 6281ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBFLO203907:GHF7-313-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Bfl313
    OrganismiBlochmannia floridanus
    Taxonomic identifieri203907 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
    ProteomesiUP000002192: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Leucine--tRNA ligasePRO_0000151994Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203907.Bfl313.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VRA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi625 – 6295"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VRA6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKLYFPHQI ERIVQQHWND NQTFSVTEDK NKQKFYCLSM LPYPSGNLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEQAA IIHKKNPSDW 100
    TYSNIQYMKQ QLKSLGFAYD WKRELITNDP QYYRWEQWFF IILYEKGLVY 150
    RKTTLVNWCP YHNTVLANEQ VINGGCWRCH TKIQYKKIPQ WFIKITHYAD 200
    QLLNGLNQLQ YWPEQVKTMQ RNWIGQSTGT NVIFKILNSN ITTITVYIAR 250
    LDTFMGISYL TISVDHPITL QIAKINPDLA NFISIYNTIS IQLHNKQFIC 300
    HKKKGIFTNL YAVHPITFTK LPIWVANFIT PLEFDGQGAI ASCPAHDQHD 350
    WEFAHQYDLP IKPVIKYADG ELPNITNQAM IEPGILFNSD NFDDLTSHTA 400
    INYISKKLID LKIAKTKIFY HLQDWGVSRQ RYWGVPIPMI KLKNGIIQPV 450
    PKSELPVILP EIIYTKNNEN NILSKNFNWT HTTYKNQDVI RDTDTFDTFM 500
    ESSWYYARYT CPHYHDGMLQ SDAANYWLPI DQYIGGIEHA TMHLMYFRFY 550
    HKLMRDIGLI QSNEPAIRLL CQGMILADSF YYISNDGQKN WVSPNKVIST 600
    RDKMGHIIKS IDADGNNVIY AGLCKMSKSK NNGIDPNAMI QKYGADAVRF 650
    FIMFAAPAHS TLEWKESGIE GALRFLKRLW NITYQHIQNG LIHQLNMYKL 700
    ENKHKIIRQK VHETIIKVTD DIDRRQSFNT ALAAIMKLFN DIQDIFPINN 750
    TQDRSVLHEA LSIIVKLLYP FTPHISYILW KELGYTNTID DTTWPTPDLQ 800
    AIQTQEILII VQINGKKKKK IFVPINSDKN TIHEIAKQAI YQDKNLESKY 850
    VHKIIYIPNK IINFITK 867
    Length:867
    Mass (Da):101,320
    Last modified:October 1, 2003 - v1
    Checksum:iB8A6FB76B78356C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248583 Genomic DNA. Translation: CAD83383.1.
    RefSeqiNP_878608.1. NC_005061.1.
    WP_011126591.1. NC_005061.1.

    Genome annotation databases

    EnsemblBacteriaiCAD83383; CAD83383; Bfl313.
    GeneIDi1499513.
    KEGGibfl:Bfl313.
    PATRICi31964227. VBICanBlo38691_0307.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248583 Genomic DNA. Translation: CAD83383.1 .
    RefSeqi NP_878608.1. NC_005061.1.
    WP_011126591.1. NC_005061.1.

    3D structure databases

    ProteinModelPortali Q7VRA6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203907.Bfl313.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD83383 ; CAD83383 ; Bfl313 .
    GeneIDi 1499513.
    KEGGi bfl:Bfl313.
    PATRICi 31964227. VBICanBlo38691_0307.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BFLO203907:GHF7-313-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYL_BLOFL
    AccessioniPrimary (citable) accession number: Q7VRA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3