Reviewed, UniProtKB/Swiss-Prot Q7VR76 (KPRS_BLOFL)

Names and origin

Protein names

Recommended name:
    Ribose-phosphate pyrophosphokinase
      Short name=RPPK
    EC=2.7.6.1
Alternative name(s):
    Phosphoribosyl pyrophosphate synthetase
      Short name=P-Rib-PP synthetase
      Short name=PRPP synthetase

Gene names

Name:	prs
Synonyms:	prsA
Ordered Locus Names:	Bfl346

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583
Subcellular location	Cytoplasm By similarity HAMAP MF_00583.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Ribose-phosphate pyrophosphokinase HAMAP MF_00583		PRO_0000141122
Regions
	Region	210 – 223	14	Binding of phosphoribosylpyrophosphate Potential
Sites
	Metal binding	126	1	Magnesium Potential
	Metal binding	128	1	Magnesium Potential
	Metal binding	137	1	Magnesium Potential
	Metal binding	141	1	Magnesium Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VR76-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 90365A3F110BFC2D	FASTA	314	34,747
	10 20 30 40 50 60 MKLFTGNAIP ELAQRIADKL YITLGNASVG RFSDGEVSVQ INENVRGGDI FIIQSTCAPT 70 80 90 100 110 120 NDNLIELIVM VDALRRASAA RITAVIPYFG YARQDRRVRS ARVPITSRVV ANFLSSVGVD 130 140 150 160 170 180 RILTVDLHAE QIQGFFDVPV DNVFGSPILL EDMLQQKFNN PIVVSPDIGG VMRARAIAKL 190 200 210 220 230 240 FNDTDMAIID KRRPRSNVSQ IMNIIGDVYN RDCILIDDMI DTGGTLCKAA DVLKDKGACR 250 260 270 280 290 300 VFAYATHPIF SGNAYENIQK SMIDEIIICD TIPLKSKIRT LPNIRILTLS GMLAETIRRI 310 SNEESISAMF DYSI

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248583 Genomic DNA. Translation: CAD83413.1.
RefSeq	NP_878638.1.
3D structure databases
SMR	Q7VR76. Positions 1-306.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7VR76.
Genome annotation databases
GeneID	1499546.
GenomeReviews	Gene locus Bfl346 in contig BX248583_GR.
KEGG	bfl:Bfl346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0462.
HOGENOM	HBG519284.
OMA	CATHAVF.
PhylomeDB	Q7VR76.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL346-MONOMER.
Family and domain databases
HAMAP	MF_00583_B. RibP_PPkinase_B. [Tree]
InterPro	IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. ribP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS_BLOFL

Accession

Primary (citable) accession number: Q7VR76

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	October 1, 2003
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)