Q7VR52 (SYY_BLOFL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine--tRNA ligase EC=6.1.1.1 Alternative name(s): Tyrosyl-tRNA synthetase Short name=TyrRS | ||||
| Gene names |
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| Organism | Blochmannia floridanus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 203907 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia |
Protein attributes
| Sequence length | 422 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP MF_02006 |
| Catalytic activity | ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP MF_02006 |
| Subunit structure | Homodimer By similarity. HAMAP MF_02006 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_02006. |
| Sequence similarities | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. Contains 1 S4 RNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding RNA-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tyrosyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA bindingInferred from electronic annotation. Source: UniProtKB-KW tyrosine-tRNA ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 422 | 422 | Tyrosine--tRNA ligase HAMAP MF_02006 | PRO_0000234684 | |||||
Regions | |||||||||
| Domain | 354 – 411 | 58 | S4 RNA-binding | ||||||
| Motif | 41 – 50 | 10 | "HIGH" region HAMAP MF_02006 | ||||||
| Motif | 235 – 239 | 5 | "KMSKS" region HAMAP MF_02006 | ||||||
Sites | |||||||||
| Binding site | 36 | 1 | Tyrosine By similarity | ||||||
| Binding site | 175 | 1 | Tyrosine By similarity | ||||||
| Binding site | 179 | 1 | Tyrosine By similarity | ||||||
| Binding site | 238 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX248583 Genomic DNA. Translation: CAD83437.1. |
| RefSeq | NP_878662.1. NC_005061.1. |
3D structure databases | |
| ProteinModelPortal | Q7VR52. |
| SMR | Q7VR52. Positions 4-319. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q7VR52. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1499571. |
| GenomeReviews | Gene locus Bfl371 in contig BX248583_GR. |
| KEGG | bfl:Bfl371. |
| PATRIC | 31964343. VBICanBlo38691_0361. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0162. |
| HOGENOM | HBG288125. |
| OMA | TFYIGFD. |
| PhylomeDB | Q7VR52. |
| ProtClustDB | PRK05912. |
Enzyme and pathway databases | |
| BioCyc | CBLO203907:BFL371-MONOMER. |
Family and domain databases | |
| HAMAP | MF_02006. Tyr_tRNA_synth_type1. [Tree] |
| InterPro | IPR001412. aa-tRNA-synth_I_CS. IPR002305. aa-tRNA-synth_Ic. IPR014729. Rossmann-like_a/b/a_fold. IPR002942. S4_RNA-bd. IPR002307. Tyr-tRNA-synth. IPR024088. Tyr-tRNA-synth_bac-type. IPR024107. Tyr-tRNA-synth_bac_1. [Graphical view] |
| Gene3D | G3DSA:3.10.290.10. G3DSA:3.10.290.10. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| KO | K01866. |
| PANTHER | PTHR11766. Tyr_tRNA-synt_1b. 1 hit. |
| Pfam | PF00579. tRNA-synt_1b. 1 hit. [Graphical view] |
| PRINTS | PR01040. TRNASYNTHTYR. |
| SMART | SM00363. S4. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00234. TyrS. 1 hit. |
| PROSITE | PS00178. AA_TRNA_LIGASE_I. 1 hit. PS50889. S4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYY_BLOFL | ||||||||
| Accession | Primary (citable) accession number: Q7VR52 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| SIMILARITY comments Index of protein domains and families |

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