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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Blochmannia floridanus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi378 – 385ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Bfl379
OrganismiBlochmannia floridanus
Taxonomic identifieri203907 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
Proteomesi
  • UP000002192 Componenti: Chromosome

Subcellular locationi

Q7VR44:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalUniRule annotationAdd BLAST21
Transmembranei105 – 127HelicalUniRule annotationAdd BLAST23
Transmembranei143 – 163HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei277 – 297HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925731 – 583Lipid A export ATP-binding/permease protein MsbAAdd BLAST583

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi203907.Bfl379.

Structurei

3D structure databases

ProteinModelPortaliQ7VR44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini344 – 580ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VR44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYCNNGNIS NWKVFRRLWP IINPFKIGLI IASITLIINA VSDSLMLALL
60 70 80 90 100
KPLLDEGFGK ANRSIFMWMP LVLMGLMIMR GMSGFASTYC ISWVSGKVVM
110 120 130 140 150
HIRRLLFNHI MNMPVSFFIE QSTATLMSRI TYDADQVASS SSGALITIIR
160 170 180 190 200
EGASVVGLCI MMFYYSWQLS LVLILIMPII SIIIKLVSNK FKDIGKKIQN
210 220 230 240 250
SMSQLVNSVE QMLKGHKEVL IFGGQHLEQN RFNYLSNRMR QYTMKMVQTS
260 270 280 290 300
SVFEPLIQFV ASLALACVLY IASIPSVIEM LSAGTITVIF SSMIALMKPL
310 320 330 340 350
KSLTNVSAQF QRGMVACQTL FTILDLKTEK NIGKFSVKRV KGHIIFDNVT
360 370 380 390 400
FFYPETNTPS LCNINFNIES GKTIALVGRS GSGKSTIVNL LTRFYDVYQG
410 420 430 440 450
RILLDGLNLN DYTLTSLREQ VSVVTQNVYL FNDTIANNIA YARTRFYSRA
460 470 480 490 500
SIEEAAKMAY AMGFISKMKN GFDTIVGENG ILLSNGQRQR IAIARALLRN
510 520 530 540 550
CPILILDEAT SSLDTESECI IYKSINILKK NRTSLIIAHR LSTIENADEI
560 570 580
LVVERGSIVE RGIHVDLLNH KGVYSQLYKF QFS
Length:583
Mass (Da):65,499
Last modified:October 1, 2003 - v1
Checksum:iD4B5B840829342D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248583 Genomic DNA. Translation: CAD83445.1.
RefSeqiWP_011126653.1. NC_005061.1.

Genome annotation databases

EnsemblBacteriaiCAD83445; CAD83445; Bfl379.
KEGGibfl:Bfl379.

Similar proteinsi

Entry informationi

Entry nameiMSBA_BLOFL
AccessioniPrimary (citable) accession number: Q7VR44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families