Reviewed, UniProtKB/Swiss-Prot Q7VR18 (FABH_BLOFL)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3
    EC=2.3.1.180
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase III
    Beta-ketoacyl-ACP synthase III
      Short name=KAS III

Gene names

Name:	fabH
Ordered Locus Names:	Bfl406

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity.
Catalytic activity	Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Probable.
Domain	The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH By similarity.
Sequence similarities	Belongs to the fabH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP beta-ketoacyl-acyl-carrier-protein synthase III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815		PRO_0000110410
Regions
	Region	246 – 250	5	ACP-binding By similarity
Sites
	Active site	112	1	By similarity
	Active site	245	1	By similarity
	Active site	275	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VR18-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 69DFEBD14EE47673	FASTA	318	34,711
	10 20 30 40 50 60 MFTKILGTGS YLPKYIRSNI ILEKMVDTSN AWIIARTGIK ERRISNSSET VAKMGYFASK 70 80 90 100 110 120 KALDMSCIEA NEIGIIIVAT TSSSHAFPSS ACQIQRDLKI SDTIAFDLSA ACSGFVYALD 130 140 150 160 170 180 VANQYIKNGV VKYALIVGSD ILSHFLNPND RSTLILFGDG AGAVILGRSK SPGIISTHLH 190 200 210 220 230 240 ANGYYGDLLT LPHYNTQNPE KLSVYLTMSG NKVFKMAIAT LTGIINETLH ANNLQQDELD 250 260 270 280 290 300 WLVPHQANLR IISKAAKRLN IDMEKIIITL HKHGNTSAAS IPLALDEAVR DGRIKSNQLL 310 LLEAFGAGLT WGSVLLRF

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83472.1.
RefSeq	NP_878697.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7VR18.
Genome annotation databases
GeneID	1499606.
GenomeReviews	Gene locus Bfl406 in contig BX248583_GR.
KEGG	bfl:Bfl406.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VR18.
OMA	FRIIKAT.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL406-MON.
Family and domain databases
HAMAP	MF_01815. [Tree]
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00747. fabH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABH_BLOFL

Accession

Primary (citable) accession number: Q7VR18

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)