Reviewed, UniProtKB/Swiss-Prot Q7VR12 (PGSA_BLOFL)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	Bfl415

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. HAMAP MF_01437
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. HAMAP MF_01437
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase HAMAP MF_01437		PRO_0000239121
Regions
	Topological domain	6 – 17	12	Cytoplasmic Potential
	Transmembrane	18 – 42	25	Potential
	Topological domain	43 – 65	23	Periplasmic Potential
	Transmembrane	66 – 86	21	Potential
	Topological domain	87 – 91	5	Cytoplasmic Potential
	Transmembrane	92 – 112	21	Potential
	Topological domain	113 – 150	38	Periplasmic Potential
	Transmembrane	151 – 173	23	Potential
	Topological domain	174 – 186	13	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VR12-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 1FA9F4640E093EBE	FASTA	190	22,342
	10 20 30 40 50 60 MFKYYGVFNI PMYLTLFRII MVPCFVAVFY WPIYWSPMLC TLIFFIAAIT DWFDGFLARR 70 80 90 100 110 120 WNQTSRIGGF LDPIADKIMI ITALILISEH FHVWWMTLPI SSIIIREILI SSLRECIARV 130 140 150 160 170 180 DNKNNISVIW LSKVKTFAQM LALIALLCRL NEWTVIMGVI SLYTAMLLTL WSMCYYVYSV 190 SSILLQYKLK

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83479.1.
RefSeq	NP_878703.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7VR12.
Genome annotation databases
GeneID	1499615.
GenomeReviews	Gene locus Bfl415 in contig BX248583_GR.
KEGG	bfl:Bfl415.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VR12.
OMA	ISATDYF.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL415-MON.
Family and domain databases
HAMAP	MF_01437. [Tree]
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. pgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_BLOFL

Accession

Primary (citable) accession number: Q7VR12

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)