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Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Blochmannia floridanus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase-2 (ribA)
  2. Riboflavin biosynthesis protein RibD (ribD)
  3. Riboflavin biosynthesis protein RibD (ribD)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Zinc; catalyticUniRule annotation1
Metal bindingi65Zinc; catalyticUniRule annotation1
Metal bindingi67Zinc; catalyticUniRule annotation1
Binding sitei70GTPUniRule annotation1
Binding sitei114GTPUniRule annotation1
Active sitei126Proton acceptorUniRule annotation1
Active sitei128NucleophileUniRule annotation1
Binding sitei149GTPUniRule annotation1
Binding sitei154GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 53GTPUniRule annotation5
Nucleotide bindingi92 – 94GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processRiboflavin biosynthesis
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCBLO203907:G1GJ5-426-MONOMER
UniPathwayiUPA00275; UER00400

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IIUniRule annotation
Gene namesi
Name:ribAUniRule annotation
Ordered Locus Names:Bfl425
OrganismiBlochmannia floridanus
Taxonomic identifieri203907 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
Proteomesi
  • UP000002192 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001517481 – 199GTP cyclohydrolase-2Add BLAST199

Proteomic databases

PRIDEiQ7VR05

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi203907.Bfl425

Structurei

3D structure databases

ProteinModelPortaliQ7VR05
SMRiQ7VR05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase II family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T1C Bacteria
COG0807 LUCA
HOGENOMiHOG000115442
KOiK01497
OMAiGQGFILY
OrthoDBiPOG091H008U

Family and domain databases

CDDicd00641 GTP_cyclohydro2, 1 hit
Gene3Di3.40.50.10990, 1 hit
HAMAPiMF_00179 RibA, 1 hit
InterProiView protein in InterPro
IPR032677 GTP_cyclohydro_II
IPR000926 RibA
IPR036144 RibA-like_sf
PfamiView protein in Pfam
PF00925 GTP_cyclohydro2, 1 hit
SUPFAMiSSF142695 SSF142695, 1 hit
TIGRFAMsiTIGR00505 ribA, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VR05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLKRVAEAK LPTFWGDFLI IGFKENQTEH NHIALTYGDL TGSNPVLTRI
60 70 80 90 100
HSECLTGDAL FSSRCDCGIQ LSTALRYITE EGQGILIYHR QEGRNIGLLN
110 120 130 140 150
KIRAYSLQDH GADTVEANQC LGFNADERDF TVCADILKLL NIQTIRLLTN
160 170 180 190
NPQKIEILNK SHIIVTERVP LIVGRNPKNS KYLDTKALKL GHLFSSYYK
Length:199
Mass (Da):22,473
Last modified:October 1, 2003 - v1
Checksum:iBF7D45705627AA69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248583 Genomic DNA Translation: CAD83487.1
RefSeqiWP_011126694.1, NC_005061.1

Genome annotation databases

EnsemblBacteriaiCAD83487; CAD83487; Bfl425
KEGGibfl:Bfl425

Similar proteinsi

Entry informationi

Entry nameiRIBA_BLOFL
AccessioniPrimary (citable) accession number: Q7VR05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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