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Q7VQX0

- HISX_BLOFL

UniProt

Q7VQX0 - HISX_BLOFL

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Blochmannia floridanus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NADUniRule annotation
Binding sitei191 – 1911NADUniRule annotation
Binding sitei214 – 2141NADUniRule annotation
Binding sitei240 – 2401SubstrateUniRule annotation
Metal bindingi262 – 2621ZincUniRule annotation
Binding sitei262 – 2621SubstrateUniRule annotation
Metal bindingi265 – 2651ZincUniRule annotation
Binding sitei265 – 2651SubstrateUniRule annotation
Active sitei329 – 3291Proton acceptorUniRule annotation
Active sitei330 – 3301Proton acceptorUniRule annotation
Binding sitei330 – 3301SubstrateUniRule annotation
Metal bindingi363 – 3631ZincUniRule annotation
Binding sitei363 – 3631SubstrateUniRule annotation
Binding sitei417 – 4171SubstrateUniRule annotation
Metal bindingi422 – 4221ZincUniRule annotation
Binding sitei422 – 4221SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBFLO203907:GHF7-463-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:Bfl463
OrganismiBlochmannia floridanus
Taxonomic identifieri203907 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
ProteomesiUP000002192: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Histidinol dehydrogenasePRO_0000135734Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi203907.Bfl463.

Structurei

3D structure databases

ProteinModelPortaliQ7VQX0.
SMRiQ7VQX0. Positions 10-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VQX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISTQYLIPT YWHRCSISEQ LTLLTRPINK HNNSIHLDVK YILDHVSKLG
60 70 80 90 100
DNALIKFNLQ FDYVNTISLK ISPNKIINSG NSLSKPIKKA IHSAIDNITR
110 120 130 140 150
FHTAQYFPKV DLEIIPGVRC KQIIRPLHTI GLYVPGGSTP LPSTVMMLGI
160 170 180 190 200
PAKIAQCKRI ILCSPPPIPN IILYTAQLCG IEEIYQVGGA QAIAAMGFGT
210 220 230 240 250
ESIPRVDKIF GPGNIWVTEA KRQIHYITNK VAIDMLAGPS EILIIADKTA
260 270 280 290 300
NPIFIAADLL SQAEHGPDSH IILITPDMNL AQQTRQELYK QIQNLDRIDI
310 320 330 340 350
IHQSLTHARI IITDNIMECF QISNDYAPEH LLIQTQNPEN YLKYITNAGS
360 370 380 390 400
IFLGHWSPES AGDYASGTNH VLPTYGHATT TSALGVADFQ KRILVQELTQ
410 420 430
HGLLQLSSTI QTLTKIEKLK AHEYSVIHRI NYIKGTT
Length:437
Mass (Da):48,711
Last modified:October 1, 2003 - v1
Checksum:iC49F52E83233E46E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248583 Genomic DNA. Translation: CAD83522.1.
RefSeqiNP_878746.1. NC_005061.1.
WP_011126729.1. NC_005061.1.

Genome annotation databases

EnsemblBacteriaiCAD83522; CAD83522; Bfl463.
GeneIDi1499663.
KEGGibfl:Bfl463.
PATRICi31964537. VBICanBlo38691_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248583 Genomic DNA. Translation: CAD83522.1 .
RefSeqi NP_878746.1. NC_005061.1.
WP_011126729.1. NC_005061.1.

3D structure databases

ProteinModelPortali Q7VQX0.
SMRi Q7VQX0. Positions 10-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203907.Bfl463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD83522 ; CAD83522 ; Bfl463 .
GeneIDi 1499663.
KEGGi bfl:Bfl463.
PATRICi 31964537. VBICanBlo38691_0451.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BFLO203907:GHF7-463-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHISX_BLOFL
AccessioniPrimary (citable) accession number: Q7VQX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3