Reviewed,
UniProtKB/Swiss-Prot Q7VQX0 (HISX_BLOFL)
Last modified
November 25, 2008.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histidinol dehydrogenase Short name=HDH EC=1.1.1.23 | ||||
| Gene names |
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| Organism | Blochmannia floridanus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 203907 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia |
Protein attributes
| Sequence length | 437 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. |
| Catalytic activity | L-histidinol + 2 NAD(+) = L-histidine + 2 NADH. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the histidinol dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Histidine biosynthesis |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activityInferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 437 | 437 | Histidinol dehydrogenase | PRO_0000135734 | |||||
Sites | |||||||||
| Active site | 329 | 1 | Proton acceptor By similarity | ||||||
| Active site | 330 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 262 | 1 | Zinc By similarity | ||||||
| Metal binding | 265 | 1 | Zinc By similarity | ||||||
| Metal binding | 363 | 1 | Zinc By similarity | ||||||
| Metal binding | 422 | 1 | Zinc By similarity | ||||||
| Binding site | 133 | 1 | NAD By similarity | ||||||
| Binding site | 191 | 1 | NAD By similarity | ||||||
| Binding site | 214 | 1 | NAD By similarity | ||||||
| Binding site | 240 | 1 | Substrate By similarity | ||||||
| Binding site | 262 | 1 | Substrate By similarity | ||||||
| Binding site | 265 | 1 | Substrate By similarity | ||||||
| Binding site | 330 | 1 | Substrate By similarity | ||||||
| Binding site | 363 | 1 | Substrate By similarity | ||||||
| Binding site | 417 | 1 | Substrate By similarity | ||||||
| Binding site | 422 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| BX248583 Genomic DNA. Translation: CAD83522.1. | |
| RefSeq | NP_878746.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1499663. |
| GenomeReviews | Gene locus Bfl463 in contig BX248583_GR. |
| KEGG | bfl:Bfl463. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q7VQX0. |
Enzyme and pathway databases | |
| BioCyc | CBLO203907:BFL463-MON. |
Family and domain databases | |
| HAMAP | MF_01024. [Tree] |
| InterPro | IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view] |
| PANTHER | PTHR21256:SF2. Hstdl_DH_prok. 1 hit. |
| Pfam | PF00815. Histidinol_dh. 1 hit. [Graphical view] |
| PRINTS | PR00083. HOLDHDRGNASE. |
| ProDom | PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00069. hisD. 1 hit. |
| PROSITE | PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HISX_BLOFL | ||||||||
| Accession | Primary (citable) accession number: Q7VQX0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


