Q7VQW4 (HIS2_BLOFL) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Histidine biosynthesis bifunctional protein HisIE | ||||||
| Gene names |
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| Organism | Blochmannia floridanus [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 203907 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia |
Protein attributes
| Sequence length | 213 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01019 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01019 |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01019 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_01019. |
| Sequence similarities | In the N-terminal section; belongs to the PRA-CH family. In the C-terminal section; belongs to the PRA-PH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Histidine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-AMP cyclohydrolase activityInferred from electronic annotation. Source: EC phosphoribosyl-ATP diphosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 213 | 213 | Histidine biosynthesis bifunctional protein HisIE HAMAP MF_01019 | PRO_0000136409 | ||||
Regions | ||||||||
| Region | 1 – 114 | 114 | Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01019 | |||||
| Region | 115 – 213 | 99 | Phosphoribosyl-ATP pyrophosphohydrolase HAMAP MF_01019 | |||||
Sequences
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References
| [1] | "The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX248583 Genomic DNA. Translation: CAD83528.1. |
| RefSeq | NP_878752.1. NC_005061.1. |
3D structure databases | |
| ProteinModelPortal | Q7VQW4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q7VQW4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1499669. |
| GenomeReviews | Gene locus Bfl469 in contig BX248583_GR. |
| KEGG | bfl:Bfl469. |
| PATRIC | 31964549. VBICanBlo38691_0457. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0139. |
| HOGENOM | HBG294308. |
| OMA | VMACKDD. |
| PhylomeDB | Q7VQW4. |
| ProtClustDB | PRK02759. |
Enzyme and pathway databases | |
| BioCyc | CBLO203907:BFL469-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01019. HisIE. [Tree] |
| InterPro | IPR023019. His_synth_HisIE. IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. IPR002496. PRib_AMP_CycHydrolase. [Graphical view] |
| KO | K11755. |
| Pfam | PF01502. PRA-CH. 1 hit. PF01503. PRA-PH. 1 hit. [Graphical view] |
| ProDom | PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR03188. Histidine_hisI. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HIS2_BLOFL | ||||||||
| Accession | Primary (citable) accession number: Q7VQW4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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