Reviewed, UniProtKB/Swiss-Prot Q7VQK8 (DAPB_BLOFL)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Bfl121

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Dihydrodipicolinate reductase		PRO_0000141424

Sequences

	Sequence		Length	Mass (Da)
	Q7VQK8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 19167614D6BBED85	FASTA	274	30,182
	10 20 30 40 50 60 MRLAVTGVTG RMGKSIIQRI IQTQAHQVDN KFILGAAIAR DRSDICGIDA GTFVQSSKVG 70 80 90 100 110 120 VFITDNIELV KGDFDVLIDF TAPESTMNYV NFCVMNNKNM VIGTTGLSKS YLSVIERASS 130 140 150 160 170 180 KIGIVYSANF SVGITIMLKL LNSVSKISRY FVNIDIVESH HNKKKDIPSG TALLIRNVVE 190 200 210 220 230 240 YNQFSDCVCN EDLVSNGEKK YGKLDNDIKI HSIRAGDIVG EHSVLCTSIG ERLEIKHQAF 250 260 270 NRIIFVDGAL RSAVWLGCAK IGLFDLNNVL KINM

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83642.1.
RefSeq	NP_878427.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1499321.
GenomeReviews	Gene locus Bfl121 in contig BX248583_GR.
KEGG	bfl:Bfl121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VQK8.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL121-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BLOFL

Accession

Primary (citable) accession number: Q7VQK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	October 1, 2003
Last modified:	November 25, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)