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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Blochmannia floridanus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Bfl139
OrganismiBlochmannia floridanus
Taxonomic identifieri203907 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia
Proteomesi
  • UP000002192 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei133 – 153HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei202 – 222HelicalUniRule annotationAdd BLAST21
Transmembranei242 – 262HelicalUniRule annotationAdd BLAST21
Transmembranei266 – 286HelicalUniRule annotationAdd BLAST21
Transmembranei291 – 311HelicalUniRule annotationAdd BLAST21
Transmembranei341 – 361HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088031 – 365Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST365

Interactioni

Protein-protein interaction databases

STRINGi203907.Bfl139.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VQJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFWIIKITS YFYSSTLFEV MNSVLFRGVG GLFFSLFISI VIGNRIIVWL
60 70 80 90 100
KYKLRMLQTI RIDGPQSHKL KYGTPTMGGI IILISVVTSV IIWSDLSNIY
110 120 130 140 150
IWYILFIFVM YGILGLVDDF LKIKRGDNLG LTILNKYLWQ SIIAWILIVI
160 170 180 190 200
MFINRVNYVE NQSGLEFLRN IVCKLKIWDM ILAYFVIVGT SNSVNLSDGL
210 220 230 240 250
DGLVIVPVIL VVSGLAIVTW VVGNIYITSD LYIEHVDCIK ELVVVCASII
260 270 280 290 300
GAGLGFLWFN SYPSQIFMGD VGSLSLGGVI GLVSILLHQE YLLLIMGGIF
310 320 330 340 350
VIESLSVIFQ VSYFKIFKKR IFKMAPIHHH FELKGYMEPK IVVRFWIVSS
360
ILVLLSIVIF ILSKY
Length:365
Mass (Da):41,504
Last modified:October 1, 2003 - v1
Checksum:iE7A2EEFC10966B14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248583 Genomic DNA. Translation: CAD83660.1.
RefSeqiWP_011126428.1. NC_005061.1.

Genome annotation databases

EnsemblBacteriaiCAD83660; CAD83660; Bfl139.
KEGGibfl:Bfl139.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BLOFL
AccessioniPrimary (citable) accession number: Q7VQJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families