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Reviewed, UniProtKB/Swiss-Prot Q7VQH1 (CYSI_BLOFL)

Last modified February 9, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sulfite reductase [NADPH] hemoprotein beta-component
      Short name=SiR-HP
      Short name=SiRHP
    EC=1.8.1.2
Gene names
Name: cysI
Ordered Locus Names: Bfl159
OrganismBlochmannia floridanus [Complete proteome] [HAMAP]
Taxonomic identifier203907 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeant endosymbiontsCandidatus Blochmannia

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity. HAMAP MF_01540

Catalytic activity

H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH. HAMAP MF_01540

Cofactor

Binds 1 siroheme per subunit By similarity. HAMAP MF_01540

Binds 1 4Fe-4S cluster per subunit By similarity. HAMAP MF_01540

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. HAMAP MF_01540

Subunit structure

Alpha(8)-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity. HAMAP MF_01540

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Sulfite reductase [NADPH] hemoprotein beta-component HAMAP MF_01540
PRO_0000199895

Sites

Metal binding4331Iron-sulfur (4Fe-4S) By similarity
Metal binding4391Iron-sulfur (4Fe-4S) By similarity
Metal binding4781Iron-sulfur (4Fe-4S) By similarity
Metal binding4821Iron (siroheme axial ligand) By similarity
Metal binding4821Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VQH1-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 9F087CEF94BA2E6D

FASTA56964,902
        10         20         30         40         50         60 
MIMLKYNNKL LSDNERIKKN SNFLRGTIEK DLDNNLTGGF NVDNAQLIRF HGMYQQDDRD 

        70         80         90        100        110        120 
VRLERMNQKL EPLINMMLRC RLPGGVITSQ QWLNIDNFSE EQTLYSSIRL TTRQTFQLHG 

       130        140        150        160        170        180 
ILKPKLKGIH QLLNKLGLDS IATAGDVNRN VICTANPMES KVHYQIWELS KKISEHLLPK 

       190        200        210        220        230        240 
SKAYAEIWLN EKKIESIDSE PILSSVYLPR KFKIAIAVPP VNDVDVYAND LGLVAIKDNT 

       250        260        270        280        290        300 
GNLIGFNVLI GGGLAMTYGD KSTYPRMASE FGYINLQDIL KIVESVITVQ RDWGDRYNRR 

       310        320        330        340        350        360 
HAKTKYTLVK VGIDILKKEI ENRSGLKFSP MYPYKFTERG DKFGWIRGIN QDYWHLTLFI 

       370        380        390        400        410        420 
ENGRVCNTSN ILIKKGLSEI AKVHSGFFRI TTNQNLIISE IHQDKKDIIE DLLKQYGLLG 

       430        440        450        460        470        480 
DFVTSQRKSS MACVAFPTCP LAMAEAERFL PAFVTKVEHV MSKYNLQRDA IILRVTGCPN 

       490        500        510        520        530        540 
GCARAMLAEI GLTGRGIGRY NLYLGGNKNG TRIPRLYKEN ITEDEILHVL DITIGDWAKN 

       550        560 
RKTQESYGDY VVRAGIVRAV INSEEDFYL 

« Hide

References

[1]"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes."
Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248583 Genomic DNA. Translation: CAD83680.1.
RefSeqNP_878465.1.

3D structure databases

SMRQ7VQH1. Positions 77-568.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7VQH1.

Genome annotation databases

GeneID1499359.
GenomeReviewsGene locus Bfl159 in contig BX248583_GR.
KEGGbfl:Bfl159.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0155.
HOGENOMHBG626671.
OMAPGDNSVD.
PhylomeDBQ7VQH1.

Enzyme and pathway databases

BioCycCBLO203907:BFL159-MONOMER.

Family and domain databases

HAMAPMF_01540. CysI.
[Tree]
InterProIPR011786. CysI.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
PfamPF01077. NIR_SIR. 2 hits.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSPR00397. SIROHAEM.
TIGRFAMsTIGR02041. CysI. 1 hit.
PROSITEPS00365. NIR_SIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSI_BLOFL
AccessionPrimary (citable) accession number: Q7VQH1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents