Reviewed, UniProtKB/Swiss-Prot Q7VQB8 (AROE_BLOFL)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Bfl221

Organism

Blochmannia floridanus [Complete proteome] [HAMAP]

Taxonomic identifier

203907 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › ant endosymbionts › Candidatus Blochmannia

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021265
Regions
	Nucleotide binding	140 – 144	5	NADP By similarity
Sites
	Active site	65	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VQB8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8E380B5347418146	FASTA	294	32,923
	10 20 30 40 50 60 MSSFAIFGNP VSHSKSPKIY SMFANEFGMC GEYDLKVASD DNFYNLLYQF FDMGGFGANI 70 80 90 100 110 120 TVPFKKRAFL LCDNLTDRSI LSSTVNTIKK QLDGTLLGDN TDGIGLINDL KRLNWISIDN 130 140 150 160 170 180 AFIDMTCNNI QETANILLIG SGGAAQSIIP VLLDIKKCCV NIINRTFFNA QRLVQYYHSI 190 200 210 220 230 240 GRQNISCIDL NNLLCEKNAC KKYDLIINAS SSSMNNDLPC ISSFLITPFT KCYDLFYGNQ 250 260 270 280 290 DTIFVKWCKK NGSNYCVDGL GMLIEQAAYA FYLWHGKKPS VPIVLNAFRS ELCK

References

[1]

"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes." Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003) [PubMed: 12886019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248583 Genomic DNA. Translation: CAD83736.1.
RefSeq	NP_878520.1.
3D structure databases
HSSP	HSSP built from PDB template 1NYT based on UniProtKB P15770.
ModBase	Search...
Genome annotation databases
GeneID	1499421.
GenomeReviews	Gene locus Bfl221 in contig BX248583_GR.
KEGG	bfl:Bfl221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VQB8.
OMA	Q7VQB8. YDMMYGR.
Enzyme and pathway databases
BioCyc	CBLO203907:BFL221-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BLOFL

Accession

Primary (citable) accession number: Q7VQB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)