Reviewed,
UniProtKB/Swiss-Prot Q7VPI9 (LLDD_HAEDU)
Last modified
January 19, 2010.
Version 46.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: L-lactate dehydrogenase [cytochrome] EC=1.1.2.3 | ||||
| Gene names |
| ||||
| Organism | Haemophilus ducreyi [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 730 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 381 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559 |
| Cofactor | FMN By similarity. HAMAP MF_01559 |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lactate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 381 | 381 | L-lactate dehydrogenase [cytochrome] HAMAP MF_01559 | PRO_0000206338 | |||||
Regions | |||||||||
| Domain | 1 – 380 | 380 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 306 – 330 | 25 | FMN By similarity | ||||||
Sites | |||||||||
| Active site | 275 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 24 | 1 | Substrate Potential | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 127 | 1 | FMN By similarity | ||||||
| Binding site | 129 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | FMN By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 251 | 1 | FMN By similarity | ||||||
| Binding site | 278 | 1 | Substrate Potential | ||||||
Sequences
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References
| [1] | "The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017143 Genomic DNA. Translation: AAP95092.1. |
| RefSeq | NP_872703.1. |
3D structure databases | |
| SMR | Q7VPI9. Positions 1-376. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1490105. |
| GenomeReviews | Gene locus HD_0084 in contig AE017143_GR. |
| KEGG | hdu:HD0084. |
| NMPDR | fig|233412.1.peg.68. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG517781. |
| OMA | WIREFWE. |
Enzyme and pathway databases | |
| BioCyc | HDUC233412:HD_0084-MONOMER. |
| BRENDA | 1.1.2.3. 265031. |
Family and domain databases | |
| HAMAP | MF_01559. L-lact_dehydr. [Tree] |
| InterPro | IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LLDD_HAEDU | ||||||||
| Accession | Primary (citable) accession number: Q7VPI9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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