UniProtKB - Q7VPI9 (LLDD_HAEDU)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
L-lactate dehydrogenase
Gene
lldD
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Functioni
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation
Catalytic activityi
(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation
Cofactori
FMNUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 24 | SubstrateUniRule annotation | 1 | |
Binding sitei | 106 | FMNUniRule annotation | 1 | |
Binding sitei | 127 | FMNUniRule annotation | 1 | |
Binding sitei | 129 | SubstrateUniRule annotation | 1 | |
Binding sitei | 155 | FMNUniRule annotation | 1 | |
Binding sitei | 164 | SubstrateUniRule annotation | 1 | |
Binding sitei | 251 | FMNUniRule annotation | 1 | |
Active sitei | 275 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 278 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 306 – 330 | FMNUniRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- FMN binding Source: InterPro
- lactate dehydrogenase activity Source: InterPro
GO - Biological processi
- lactate metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Flavoprotein, FMN |
Enzyme and pathway databases
BioCyci | HDUC233412:G1G0H-73-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lldDUniRule annotation Ordered Locus Names:HD_0084 |
Organismi | Haemophilus ducreyi (strain 35000HP / ATCC 700724) |
Taxonomic identifieri | 233412 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206338 | 1 – 381 | L-lactate dehydrogenaseAdd BLAST | 381 |
Structurei
3D structure databases
ProteinModelPortali | Q7VPI9 |
SMRi | Q7VPI9 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 380 | FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST | 380 |
Sequence similaritiesi
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105DMF Bacteria COG1304 LUCA |
KOi | K00101 |
OMAi | MQLYIYK |
OrthoDBi | POG091H00L7 |
Family and domain databases
CDDi | cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit |
Gene3Di | 3.20.20.701 hit |
HAMAPi | MF_01559 L_lact_dehydr, 1 hit |
InterProi | View protein in InterPro IPR013785 Aldolase_TIM IPR012133 Alpha-hydoxy_acid_DH_FMN IPR000262 FMN-dep_DH IPR037396 FMN_HAD IPR008259 FMN_hydac_DH_AS IPR020920 LldD |
Pfami | View protein in Pfam PF01070 FMN_dh, 1 hit |
PIRSFi | PIRSF000138 Al-hdrx_acd_dh, 1 hit |
PROSITEi | View protein in PROSITE PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7VPI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIIASANDYR EAARRRVPPF MFHYADGGSF SERTLARNVS DLADLALRQR
60 70 80 90 100
VLKDMSQLNT EIELFGEKLA MPIVLAPVGA LGMYARRGEV QAAQAAENKG
110 120 130 140 150
LPFTLSTVSV CPIEEVTPAI KRPMWYQLYV LKDRGFMKSV LERAKAAGCS
160 170 180 190 200
TLVFTVDMPT PGARYRDLHS GMSGKYKEIR RVLQAMTHPR WAWDVGINGK
210 220 230 240 250
PHTLGNVSGY TGKSVGLDDY AVWLADNFDP SISWKDLEWI RDFWDGPMVI
260 270 280 290 300
KGILDVEDAK DAVRFGADGI VVSNHGGRQL DGALSSAKAL PSIADAVKGE
310 320 330 340 350
IKILADSGIR NGLDVVRMIA LGADATLIGR AFVYALSAAG RAGVENMLDI
360 370 380
FRKEMHVAMT LTSNARISDI NRDALVDLTK I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017143 Genomic DNA Translation: AAP95092.1 |
RefSeqi | WP_010944146.1, NC_002940.2 |
Genome annotation databases
EnsemblBacteriai | AAP95092; AAP95092; HD_0084 |
GeneIDi | 24944900 |
KEGGi | hdu:HD_0084 |
Similar proteinsi
Entry informationi
Entry namei | LLDD_HAEDU | |
Accessioni | Q7VPI9Primary (citable) accession number: Q7VPI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 28, 2018 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |