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Reviewed, UniProtKB/Swiss-Prot Q7VPI9 (LLDD_HAEDU)

Last modified January 19, 2010. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: HD_0084
OrganismHaemophilus ducreyi [Complete proteome] [HAMAP]
Taxonomic identifier730 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559

Cofactor

FMN By similarity. HAMAP MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords
   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381L-lactate dehydrogenase [cytochrome] HAMAP MF_01559
PRO_0000206338

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q7VPI9-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 643F5F0B0FC5B5B7

FASTA38141,732
        10         20         30         40         50         60 
MIIASANDYR EAARRRVPPF MFHYADGGSF SERTLARNVS DLADLALRQR VLKDMSQLNT 

        70         80         90        100        110        120 
EIELFGEKLA MPIVLAPVGA LGMYARRGEV QAAQAAENKG LPFTLSTVSV CPIEEVTPAI 

       130        140        150        160        170        180 
KRPMWYQLYV LKDRGFMKSV LERAKAAGCS TLVFTVDMPT PGARYRDLHS GMSGKYKEIR 

       190        200        210        220        230        240 
RVLQAMTHPR WAWDVGINGK PHTLGNVSGY TGKSVGLDDY AVWLADNFDP SISWKDLEWI 

       250        260        270        280        290        300 
RDFWDGPMVI KGILDVEDAK DAVRFGADGI VVSNHGGRQL DGALSSAKAL PSIADAVKGE 

       310        320        330        340        350        360 
IKILADSGIR NGLDVVRMIA LGADATLIGR AFVYALSAAG RAGVENMLDI FRKEMHVAMT 

       370        380 
LTSNARISDI NRDALVDLTK I

« Hide

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References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017143 Genomic DNA. Translation: AAP95092.1.
RefSeqNP_872703.1.

3D structure databases

SMRQ7VPI9. Positions 1-376.
ModBaseSearch...

Genome annotation databases

GeneID1490105.
GenomeReviewsGene locus HD_0084 in contig AE017143_GR.
KEGGhdu:HD0084.
NMPDRfig|233412.1.peg.68.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG517781.
OMAWIREFWE.

Enzyme and pathway databases

BioCycHDUC233412:HD_0084-MONOMER.
BRENDA1.1.2.3. 265031.

Family and domain databases

HAMAPMF_01559. L-lact_dehydr.
[Tree]
InterProIPR012133. a-Hydoxy_acid_DH_FMN.
IPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_cyt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLLDD_HAEDU
AccessionPrimary (citable) accession number: Q7VPI9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents