lldD

Functionⁱ

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityⁱ

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactorⁱ

FMNUniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	24	SubstrateUniRule annotation	1
Binding siteⁱ	106	FMNUniRule annotation	1
Binding siteⁱ	127	FMNUniRule annotation	1
Binding siteⁱ	129	SubstrateUniRule annotation	1
Binding siteⁱ	155	FMNUniRule annotation	1
Binding siteⁱ	164	SubstrateUniRule annotation	1
Binding siteⁱ	251	FMNUniRule annotation	1
Active siteⁱ	275	Proton acceptorUniRule annotation	1
Binding siteⁱ	278	SubstrateUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	306 – 330	FMNUniRule annotationAdd BLAST		25

GO - Molecular functionⁱ

FMN binding Source: InterPro
lactate dehydrogenase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

lactate metabolic process Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Flavoprotein, FMN

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesⁱ	Name:lldDUniRule annotation Ordered Locus Names:HD_0084
Organismⁱ	Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifierⁱ	233412 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus ducreyi
Proteomesⁱ	UP000001022 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01559
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01559

GO - Cellular componentⁱ

plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206338	1 – 381	L-lactate dehydrogenaseAdd BLAST		381

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	233412.HD0084.

STRINGⁱ

233412.HD0084.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7VPI9.
SMRⁱ	Q7VPI9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 380	FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST		380

Sequence similaritiesⁱ

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105DMF. Bacteria. COG1304. LUCA.
KEGG Orthology (KO) More...KOⁱ	K00101.
OMAⁱ	MQLYIYK.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00L7.

Family and domain databases

Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_01559. L_lact_dehydr. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. LldD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070. FMN_dh. 1 hit.
PIRSFⁱ	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7VPI9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIIASANDYR EAARRRVPPF MFHYADGGSF SERTLARNVS DLADLALRQR 
        60         70         80         90        100
VLKDMSQLNT EIELFGEKLA MPIVLAPVGA LGMYARRGEV QAAQAAENKG 
       110        120        130        140        150
LPFTLSTVSV CPIEEVTPAI KRPMWYQLYV LKDRGFMKSV LERAKAAGCS 
       160        170        180        190        200
TLVFTVDMPT PGARYRDLHS GMSGKYKEIR RVLQAMTHPR WAWDVGINGK 
       210        220        230        240        250
PHTLGNVSGY TGKSVGLDDY AVWLADNFDP SISWKDLEWI RDFWDGPMVI 
       260        270        280        290        300
KGILDVEDAK DAVRFGADGI VVSNHGGRQL DGALSSAKAL PSIADAVKGE 
       310        320        330        340        350
IKILADSGIR NGLDVVRMIA LGADATLIGR AFVYALSAAG RAGVENMLDI 
       360        370        380 
FRKEMHVAMT LTSNARISDI NRDALVDLTK I

Length:381

Mass (Da):41,732

Last modified:October 1, 2003 - v1

Checksum:ⁱ643F5F0B0FC5B5B7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017143 Genomic DNA. Translation: AAP95092.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010944146.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaⁱ	AAP95092; AAP95092; HD_0084.
GeneIDⁱ	24944900.
KEGGⁱ	hdu:HD_0084.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE017143 Genomic DNA. Translation: AAP95092.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010944146.1. NC_002940.2.

3D structure databases

ProteinModelPortalⁱ	Q7VPI9.
SMRⁱ	Q7VPI9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	233412.HD0084.

STRINGⁱ

233412.HD0084.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAP95092; AAP95092; HD_0084.
GeneIDⁱ	24944900.
KEGGⁱ	hdu:HD_0084.

Phylogenomic databases

eggNOGⁱ	ENOG4105DMF. Bacteria. COG1304. LUCA.
KEGG Orthology (KO) More...KOⁱ	K00101.
OMAⁱ	MQLYIYK.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00L7.

Family and domain databases

Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_01559. L_lact_dehydr. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. LldD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070. FMN_dh. 1 hit.
PIRSFⁱ	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LLDD_HAEDU
Accessionⁱ	Q7VPI9Primary (citable) accession number: Q7VPI9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	October 1, 2003
	Last modified:	June 7, 2017
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7VPI9 (LLDD_HAEDU)

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L-lactate dehydrogenase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ