Reviewed, UniProtKB/Swiss-Prot Q7VPI9 (LLDD_HAEDU)

Names and origin

Protein names

Recommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3

Gene names

Name:	lldD
Ordered Locus Names:	HD_0084

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).
Cofactor	FMN By similarity.
Sequence similarities	Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	L-lactate dehydrogenase [cytochrome]		PRO_0000206338
Regions
	Domain	1 – 380	380	FMN hydroxy acid dehydrogenase
	Nucleotide binding	306 – 330	25	FMN By similarity
Sites
	Active site	275	1	Proton acceptor By similarity
	Binding site	24	1	Substrate Potential
	Binding site	106	1	FMN By similarity
	Binding site	127	1	FMN By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	155	1	FMN By similarity
	Binding site	164	1	Substrate By similarity
	Binding site	251	1	FMN By similarity
	Binding site	278	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VPI9-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 643F5F0B0FC5B5B7	FASTA	381	41,732
	10 20 30 40 50 60 MIIASANDYR EAARRRVPPF MFHYADGGSF SERTLARNVS DLADLALRQR VLKDMSQLNT 70 80 90 100 110 120 EIELFGEKLA MPIVLAPVGA LGMYARRGEV QAAQAAENKG LPFTLSTVSV CPIEEVTPAI 130 140 150 160 170 180 KRPMWYQLYV LKDRGFMKSV LERAKAAGCS TLVFTVDMPT PGARYRDLHS GMSGKYKEIR 190 200 210 220 230 240 RVLQAMTHPR WAWDVGINGK PHTLGNVSGY TGKSVGLDDY AVWLADNFDP SISWKDLEWI 250 260 270 280 290 300 RDFWDGPMVI KGILDVEDAK DAVRFGADGI VVSNHGGRQL DGALSSAKAL PSIADAVKGE 310 320 330 340 350 360 IKILADSGIR NGLDVVRMIA LGADATLIGR AFVYALSAAG RAGVENMLDI FRKEMHVAMT 370 380 LTSNARISDI NRDALVDLTK I

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017143 Genomic DNA. Translation: AAP95092.1.
RefSeq	NP_872703.1.
3D structure databases
HSSP	HSSP built from PDB template 1GOX based on UniProtKB P05414.
ModBase	Search...
Genome annotation databases
GeneID	1490105.
GenomeReviews	Gene locus HD_0084 in contig AE017143_GR.
KEGG	hdu:HD0084.
NMPDR	fig|233412.1.peg.68.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VPI9.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_0084-MON.
Family and domain databases
HAMAP	MF_01559. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR012133. Alpha_OHA_DHase_FMN. IPR008259. FMN_hydac_DHase_AS. IPR000262. FMN_OHA_DHase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITE	PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LLDD_HAEDU

Accession

Primary (citable) accession number: Q7VPI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 1, 2003
Last modified:	November 25, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)