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Q7VPI9

- LLDD_HAEDU

UniProt

Q7VPI9 - LLDD_HAEDU

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Protein

L-lactate dehydrogenase

Gene
lldD, HD_0084
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain By similarity.

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.

Cofactori

FMN By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Substrate Reviewed prediction
Binding sitei106 – 1061FMN By similarity
Binding sitei127 – 1271FMN By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei155 – 1551FMN By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei251 – 2511FMN By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei278 – 2781Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi306 – 33025FMN By similarityAdd
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. L-lactate dehydrogenase (cytochrome) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-83-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.-.-)
Gene namesi
Name:lldD
Ordered Locus Names:HD_0084
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381L-lactate dehydrogenasePRO_0000206338Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD0084.

Structurei

3D structure databases

ProteinModelPortaliQ7VPI9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 380380FMN hydroxy acid dehydrogenaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
KOiK00101.
OMAiDCTLLGR.
OrthoDBiEOG6HMXBG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VPI9-1 [UniParc]FASTAAdd to Basket

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MIIASANDYR EAARRRVPPF MFHYADGGSF SERTLARNVS DLADLALRQR    50
VLKDMSQLNT EIELFGEKLA MPIVLAPVGA LGMYARRGEV QAAQAAENKG 100
LPFTLSTVSV CPIEEVTPAI KRPMWYQLYV LKDRGFMKSV LERAKAAGCS 150
TLVFTVDMPT PGARYRDLHS GMSGKYKEIR RVLQAMTHPR WAWDVGINGK 200
PHTLGNVSGY TGKSVGLDDY AVWLADNFDP SISWKDLEWI RDFWDGPMVI 250
KGILDVEDAK DAVRFGADGI VVSNHGGRQL DGALSSAKAL PSIADAVKGE 300
IKILADSGIR NGLDVVRMIA LGADATLIGR AFVYALSAAG RAGVENMLDI 350
FRKEMHVAMT LTSNARISDI NRDALVDLTK I 381
Length:381
Mass (Da):41,732
Last modified:October 1, 2003 - v1
Checksum:i643F5F0B0FC5B5B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95092.1.
RefSeqiNP_872703.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95092; AAP95092; HD_0084.
GeneIDi1490105.
KEGGihdu:HD0084.
PATRICi20176791. VBIHaeDuc133973_0064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95092.1 .
RefSeqi NP_872703.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VPI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD0084.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95092 ; AAP95092 ; HD_0084 .
GeneIDi 1490105.
KEGGi hdu:HD0084.
PATRICi 20176791. VBIHaeDuc133973_0064.

Phylogenomic databases

eggNOGi COG1304.
KOi K00101.
OMAi DCTLLGR.
OrthoDBi EOG6HMXBG.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-83-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01559. L_lact_dehydr.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiLLDD_HAEDU
AccessioniPrimary (citable) accession number: Q7VPI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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