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Reviewed, UniProtKB/Swiss-Prot Q7VP66 (CARA_HAEDU)

Last modified February 9, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Carbamoyl-phosphate synthase small chain
    EC=6.3.5.5
Alternative name(s):
    Carbamoyl-phosphate synthetase glutamine chain
Gene names
Name: carA
Ordered Locus Names: HD_0235
OrganismHaemophilus ducreyi [Complete proteome] [HAMAP]
Taxonomic identifier730 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP MF_01209

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. HAMAP MF_01209

Sequence similarities

Belongs to the carA family.

Contains 1 glutamine amidotransferase type-1 domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Carbamoyl-phosphate synthase small chain HAMAP MF_01209
PRO_0000112279

Regions

Domain203 – 389187Glutamine amidotransferase type-1
Region1 – 199199CPSase HAMAP MF_01209

Sites

Active site2791Nucleophile By similarity
Active site3631 By similarity
Active site3651 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q7VP66-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7553218FAB9F38C6

FASTA38942,748
        10         20         30         40         50         60 
MFNPAILVLA DGSTFYGKSI GYQAVSAYSI GEVVFNTAMT GYQEILTDPS YAKQIVTLTY 

        70         80         90        100        110        120 
PHIGNTGTND EDNESNQIYA SGLIIRDLPL LHSNFRATSS LSDYLIQHNI IAIADIDTRR 

       130        140        150        160        170        180 
LTRILRETGS QAGCIYIPNE NESLAQAVEK AQDLAKSFGS MAGKDLAKEV TCQHRYEWQE 

       190        200        210        220        230        240 
GIWHLPTNNA GKPFNLQTTP TFHVVAYDFG IKQNILRMLA ERGCKITVVP AQTSAEDILA 

       250        260        270        280        290        300 
LNPDGIFLSN GPGDPEPCTY AIQSIRQLLN TQKPIFGICL GHQLLGLAVG AKTRKMAFGH 

       310        320        330        340        350        360 
HGANHPVQDL KTEHVLITSQ NHGFEIDEYS LPENVIVTHR SLFDNSVQGI ELTNQVAFSF 

       370        380 
QGHPEANPGP QDVAYLFDKF INAVQATKA

« Hide

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References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017143 Genomic DNA. Translation: AAP95221.1.
RefSeqNP_872832.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1490239.
GenomeReviewsGene locus HD_0235 in contig AE017143_GR.
KEGGhdu:HD0235.
NMPDRfig|233412.1.peg.197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286341.
OMAFTYPELG.

Enzyme and pathway databases

BioCycHDUC233412:HD_0235-MONOMER.
BRENDA6.3.5.5. 265031.

Family and domain databases

HAMAPMF_01209_B. CPSase_S_chain_B.
[Tree]
InterProIPR001317. CarbamoylP_synth_GATase_dom.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR011702. GATASE.
IPR017926. GATASE_1.
IPR000991. GATase_class1_C.
[Graphical view]
PANTHERPTHR11405:SF4. CarA_synth_small. 1 hit.
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
PRINTSPR00099. CPSGATASE.
PR00096. GATASE.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCARA_HAEDU
AccessionPrimary (citable) accession number: Q7VP66
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2003
Last modified: February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents