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Q7VP41 (MDH_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:HD_0264
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01516

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01516

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01516

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Malate dehydrogenase HAMAP-Rule MF_01516
PRO_0000113305

Regions

Nucleotide binding7 – 137NAD By similarity
Nucleotide binding124 – 1263NAD By similarity

Sites

Active site1841Proton acceptor By similarity
Binding site341NAD By similarity
Binding site881Substrate By similarity
Binding site941Substrate By similarity
Binding site1011NAD By similarity
Binding site1261Substrate By similarity
Binding site1601Substrate By similarity
Binding site2381NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VP41 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: CAE3E8E3D351AAFB

FASTA32434,248
        10         20         30         40         50         60 
MKVTVLGAAG GIGQTLSLLL KLRLPAGADL ALYDISPVTP GIAVDISHIP TSVNAIGYAG 

        70         80         90        100        110        120 
EDPSVALKDP SVALKDTNLV IITAGIARKP GMTRADLFNI NAGIVKDLVE KVAEVCPMAC 

       130        140        150        160        170        180 
IGIVTNPVNT LVPIAAEVLR KAGVYDKSKL FGVTTLDVVR AKTFVSELKH KNVETVTVPV 

       190        200        210        220        230        240 
VGGHSGTTIL PLLSQALAEG RLLDFSQTEI ESLTQRIKNA GTEVVEAKAG GGSATLSMAE 

       250        260        270        280        290        300 
SGARFALAVF KALLGEDCVR YAYVQSKEGS GYPEFFAHPV RFGLKGIEEI LPIAPLNEYE 

       310        320 
QTQFEELKPI LEADIELGKK FVNP 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP95246.1.
RefSeqNP_872857.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VP41.
SMRQ7VP41. Positions 1-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD0264.

Proteomic databases

PRIDEQ7VP41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP95246; AAP95246; HD_0264.
GeneID1490265.
KEGGhdu:HD0264.
PATRIC20177093. VBIHaeDuc133973_0214.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
KOK00024.
OMAVEVKGFA.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-243-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01516. Malate_dehydrog_1.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_HAEDU
AccessionPrimary (citable) accession number: Q7VP41
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families