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Protein

Malate dehydrogenase

Gene

mdh

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei101NADUniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei160SubstrateUniRule annotation1
Active sitei184Proton acceptorUniRule annotation1
Binding sitei238NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 13NADUniRule annotation7
Nucleotide bindingi124 – 126NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciHDUC233412:G1G0H-209-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:HD_0264
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133051 – 324Malate dehydrogenaseAdd BLAST324

Proteomic databases

PRIDEiQ7VP41

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi233412.HD0264

Structurei

3D structure databases

ProteinModelPortaliQ7VP41
SMRiQ7VP41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H036H

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01516 Malate_dehydrog_1, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VP41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTVLGAAG GIGQTLSLLL KLRLPAGADL ALYDISPVTP GIAVDISHIP
60 70 80 90 100
TSVNAIGYAG EDPSVALKDP SVALKDTNLV IITAGIARKP GMTRADLFNI
110 120 130 140 150
NAGIVKDLVE KVAEVCPMAC IGIVTNPVNT LVPIAAEVLR KAGVYDKSKL
160 170 180 190 200
FGVTTLDVVR AKTFVSELKH KNVETVTVPV VGGHSGTTIL PLLSQALAEG
210 220 230 240 250
RLLDFSQTEI ESLTQRIKNA GTEVVEAKAG GGSATLSMAE SGARFALAVF
260 270 280 290 300
KALLGEDCVR YAYVQSKEGS GYPEFFAHPV RFGLKGIEEI LPIAPLNEYE
310 320
QTQFEELKPI LEADIELGKK FVNP
Length:324
Mass (Da):34,248
Last modified:October 1, 2003 - v1
Checksum:iCAE3E8E3D351AAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017143 Genomic DNA Translation: AAP95246.1
RefSeqiWP_010944299.1, NC_002940.2

Genome annotation databases

EnsemblBacteriaiAAP95246; AAP95246; HD_0264
GeneIDi24945140
KEGGihdu:HD_0264

Similar proteinsi

Entry informationi

Entry nameiMDH_HAEDU
AccessioniPrimary (citable) accession number: Q7VP41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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