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Q7VP38 (SYR_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:HD_0268
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151563

Regions

Motif108 – 11811"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q7VP38 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 81FA60A136FFA78D

FASTA56162,759
        10         20         30         40         50         60 
MMIAGAEANV EPLVRQSSKP EFGDYQANGA MAAAKKLAMN PREFAQKILD NLDVSDMVDK 

        70         80         90        100        110        120 
LEIAGPGFIN IFLKPSWLAK QANFALQAVN FGIKTAQPQT ILIDYSSPNV AKEMHVGHLR 

       130        140        150        160        170        180 
STIIGDAVVR TLEFLGNNVI RANHVGDWGT QFGMLIAYLE KMENEQASEM QLSDLEAFYR 

       190        200        210        220        230        240 
AAKESYDSDQ IFAEKARNYV VKLQSGDEYC RTMWKKLVDI TMHHNQENYD RLNVTLTEKD 

       250        260        270        280        290        300 
VMGESLYNPM LPEIVADLKA KGLAVEDNGA VVVFLDEFKN KDGDPMGVII QKSDGGFLYT 

       310        320        330        340        350        360 
TTDIAAAKYR YETLKVDRAL VFSDSRQAQH MQQAWLITRK AGYVPASFSL EHPFFGMMLG 

       370        380        390        400        410        420 
KDGKPFKTRS GGTVKLKDLL DEAVERADKL ISARSTNLTV AEKSAVVEAV AIGSVKYSDL 

       430        440        450        460        470        480 
SKNRTTDYVF DWDNMLTFEG NTAPYMQYAY TRIRSIFARA EIDPDTLTGE MQLTEEKERT 

       490        500        510        520        530        540 
LALKLLQFEE ALTAVAKEGM PHILCQYLYE LAGIFSSFYE ACPMLNADEA IKHSRLRLAS 

       550        560 
LTAKTLKQGL DLLGIKTVEK M 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP95249.1.
RefSeqNP_872860.2. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VP38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD0268.

Proteomic databases

PRIDEQ7VP38.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP95249; AAP95249; HD_0268.
GeneID1490268.
KEGGhdu:HD0268.
PATRIC20177099. VBIHaeDuc133973_0217.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-246-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_HAEDU
AccessionPrimary (citable) accession number: Q7VP38
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries