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Q7VP04

- RLMKL_HAEDU

UniProt

Q7VP04 - RLMKL_HAEDU

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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene
rlmL, HD_0307
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/L
Including the following 2 domains:
23S rRNA m2G2445 methyltransferase (EC:2.1.1.173)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmL
23S rRNA m7G2069 methyltransferase (EC:2.1.1.264)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmK
Gene namesi
Name:rlmL
Ordered Locus Names:HD_0307
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Ribosomal RNA large subunit methyltransferase K/LUniRule annotationPRO_0000366759Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD0307.

Structurei

3D structure databases

ProteinModelPortaliQ7VP04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 157112THUMPAdd
BLAST

Sequence similaritiesi

Contains 1 THUMP domain.

Phylogenomic databases

eggNOGiCOG0116.
KOiK12297.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VP04-1 [UniParc]FASTAAdd to Basket

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MSNQITYFAT AARGFEEMLK IELEQICGAD GKVVQGGVHF TTNQKGAYQA    50
LLHSRLASRI LLPLVSTKIF SDLDLYATII AINWADIFDP RDTFYVDFNG 100
TNREIRNTQF GAMRVKDGIV DYFERKRFAR PIVDKDRPDI RIHVYLDREK 150
LIVSLDLSGE ALHMRGYRED TGKAPLRETL AAIIVLRSGW QKGTPLVDPM 200
CGSGTLLIEA AQMQAGIVPQ LQRKYWGFNA WKGHQQAIWQ QVLEEAHSQK 250
NTQIDPLFYG FDLDHRVLAK AKQNAQNAGV AHLIHWQQAD IAALKNPCLD 300
QKGTLVSNPP YGERLGTTPA LIALYSVFGQ RLKQQFAGWN VSIFSGEPSL 350
LNCLRLRSTR QFKAKNGPLD CLQKNYQIAE YAIHNQHISE SSVAQNTQVA 400
PDFANRLTKN IKKIEKWAKQ QQLDAYRLYD ADLPEYNFAV DRYSDHIVIQ 450
EYAAPKSIEQ NKARQRLLDA VTATLHVTGI ETNKLVLKVR QKQKGTNQYE 500
KLANKGEYFY VNEYGAKLWV NLTDYLDTGI FLDHRLTRKM VGQMAKGKTF 550
LNLFAYTGSA TIHAALHGAK ATTSVDMSNT YLNWAEQNLE LNGLKSRNHR 600
LFQADCLQWL AECRERFELI FVDPPTFSNS KRMEDSWDVQ RDHIKLMTQL 650
KRILTSDGMI VFSNNKRGFK MDFNGLTALG LVAENISYKT LPLDFERDPH 700
IHNCWIIRHI EN 712
Length:712
Mass (Da):81,310
Last modified:March 24, 2009 - v2
Checksum:iF035F3E436AA0BAB
GO

Sequence cautioni

The sequence AAP95286.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95286.1. Different initiation.
RefSeqiNP_872897.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95286; AAP95286; HD_0307.
GeneIDi1490306.
KEGGihdu:HD0307.
PATRICi20177169. VBIHaeDuc133973_0252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95286.1 . Different initiation.
RefSeqi NP_872897.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VP04.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD0307.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95286 ; AAP95286 ; HD_0307 .
GeneIDi 1490306.
KEGGi hdu:HD0307.
PATRICi 20177169. VBIHaeDuc133973_0252.

Phylogenomic databases

eggNOGi COG0116.
KOi K12297.
OrthoDBi EOG6HJ238.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-284-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiRLMKL_HAEDU
AccessioniPrimary (citable) accession number: Q7VP04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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