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Q7VP04

- RLMKL_HAEDU

UniProt

Q7VP04 - RLMKL_HAEDU

Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
    S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

    GO - Molecular functioni

    1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: UniProtKB-HAMAP
    3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-284-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
    Including the following 2 domains:
    23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
    23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
    Gene namesi
    Name:rlmLUniRule annotation
    Ordered Locus Names:HD_0307
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712Ribosomal RNA large subunit methyltransferase K/LPRO_0000366759Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233412.HD0307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VP04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 157112THUMPUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
    Contains 1 THUMP domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0116.
    KOiK12297.
    OrthoDBiEOG6HJ238.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    HAMAPiMF_01858. 23SrRNA_methyltr_KL.
    InterProiIPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view]
    PfamiPF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTiSM00981. THUMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VP04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNQITYFAT AARGFEEMLK IELEQICGAD GKVVQGGVHF TTNQKGAYQA    50
    LLHSRLASRI LLPLVSTKIF SDLDLYATII AINWADIFDP RDTFYVDFNG 100
    TNREIRNTQF GAMRVKDGIV DYFERKRFAR PIVDKDRPDI RIHVYLDREK 150
    LIVSLDLSGE ALHMRGYRED TGKAPLRETL AAIIVLRSGW QKGTPLVDPM 200
    CGSGTLLIEA AQMQAGIVPQ LQRKYWGFNA WKGHQQAIWQ QVLEEAHSQK 250
    NTQIDPLFYG FDLDHRVLAK AKQNAQNAGV AHLIHWQQAD IAALKNPCLD 300
    QKGTLVSNPP YGERLGTTPA LIALYSVFGQ RLKQQFAGWN VSIFSGEPSL 350
    LNCLRLRSTR QFKAKNGPLD CLQKNYQIAE YAIHNQHISE SSVAQNTQVA 400
    PDFANRLTKN IKKIEKWAKQ QQLDAYRLYD ADLPEYNFAV DRYSDHIVIQ 450
    EYAAPKSIEQ NKARQRLLDA VTATLHVTGI ETNKLVLKVR QKQKGTNQYE 500
    KLANKGEYFY VNEYGAKLWV NLTDYLDTGI FLDHRLTRKM VGQMAKGKTF 550
    LNLFAYTGSA TIHAALHGAK ATTSVDMSNT YLNWAEQNLE LNGLKSRNHR 600
    LFQADCLQWL AECRERFELI FVDPPTFSNS KRMEDSWDVQ RDHIKLMTQL 650
    KRILTSDGMI VFSNNKRGFK MDFNGLTALG LVAENISYKT LPLDFERDPH 700
    IHNCWIIRHI EN 712
    Length:712
    Mass (Da):81,310
    Last modified:March 24, 2009 - v2
    Checksum:iF035F3E436AA0BAB
    GO

    Sequence cautioni

    The sequence AAP95286.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95286.1. Different initiation.
    RefSeqiNP_872897.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP95286; AAP95286; HD_0307.
    GeneIDi1490306.
    KEGGihdu:HD0307.
    PATRICi20177169. VBIHaeDuc133973_0252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95286.1 . Different initiation.
    RefSeqi NP_872897.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VP04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD0307.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP95286 ; AAP95286 ; HD_0307 .
    GeneIDi 1490306.
    KEGGi hdu:HD0307.
    PATRICi 20177169. VBIHaeDuc133973_0252.

    Phylogenomic databases

    eggNOGi COG0116.
    KOi K12297.
    OrthoDBi EOG6HJ238.

    Enzyme and pathway databases

    BioCyci HDUC233412:GH5F-284-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    HAMAPi MF_01858. 23SrRNA_methyltr_KL.
    InterProi IPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view ]
    Pfami PF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTi SM00981. THUMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiRLMKL_HAEDU
    AccessioniPrimary (citable) accession number: Q7VP04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3