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Q7VNV1 (ADD_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:HD_0377
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Adenosine deaminase HAMAP MF_00540
PRO_0000194371

Sites

Active site2071Proton donor By similarity
Metal binding141Zinc; catalytic By similarity
Metal binding161Zinc; catalytic By similarity
Metal binding2041Zinc; catalytic By similarity
Metal binding2841Zinc; catalytic By similarity
Binding site161Substrate By similarity
Binding site181Substrate By similarity
Binding site1771Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2271Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VNV1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 907DA610EBB95A58

FASTA34437,834
        10         20         30         40         50         60 
MVLGLAQYGV IDLHLHLDGS LSPAWMIEWA KKQAVNLPAS TAEALTAYVS VPQDCSDLNE 

        70         80         90        100        110        120 
YLRCFDLPLS LLQTPEALSS AVTDLIQRLD QDGLVYAEIR FAPQLHTQRS MSQEDAVKAA 

       130        140        150        160        170        180 
LRGLQAGLAS TSLFKANLIL CCMRAADNRS ANLETICLAK QYLTKYEAGV VAIDLAGAEG 

       190        200        210        220        230        240 
LFATQHFQQE FDFANQRGVP FTIHAGEAAG PESVQQALDF GATRIGHGIR AIESETVMKQ 

       250        260        270        280        290        300 
LIDKRTPLEM CPCSNLQTKT VAQLADYPLR TFLMRGVVAT LNTDNMTVSQ TCIQQEYRLL 

       310        320        330        340 
AEQYQLSISE AKQLLLNSIA AAFLSNEDKK ALLAHIQQRY PQLI

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017143 Genomic DNA. Translation: AAP95347.1.
RefSeqNP_872958.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VNV1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1490376.
GenomeReviewsGene locus HD_0377 in contig AE017143_GR.
KEGGhdu:HD0377.
NMPDRfig|233412.1.peg.323.
PATRIC20177299. VBIHaeDuc133973_0308.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMAITLECCA.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycHDUC233412:HD_0377-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_HAEDU
AccessionPrimary (citable) accession number: Q7VNV1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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