Reviewed, UniProtKB/Swiss-Prot Q7VNV1 (ADD_HAEDU)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	HD_0377

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Adenosine deaminase HAMAP MF_00540		PRO_0000194371
Sites
	Active site	204	1	Potential
	Active site	251	1	Potential
	Active site	284	1	Potential
	Active site	285	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7VNV1-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 907DA610EBB95A58	FASTA	344	37,834
	10 20 30 40 50 60 MVLGLAQYGV IDLHLHLDGS LSPAWMIEWA KKQAVNLPAS TAEALTAYVS VPQDCSDLNE 70 80 90 100 110 120 YLRCFDLPLS LLQTPEALSS AVTDLIQRLD QDGLVYAEIR FAPQLHTQRS MSQEDAVKAA 130 140 150 160 170 180 LRGLQAGLAS TSLFKANLIL CCMRAADNRS ANLETICLAK QYLTKYEAGV VAIDLAGAEG 190 200 210 220 230 240 LFATQHFQQE FDFANQRGVP FTIHAGEAAG PESVQQALDF GATRIGHGIR AIESETVMKQ 250 260 270 280 290 300 LIDKRTPLEM CPCSNLQTKT VAQLADYPLR TFLMRGVVAT LNTDNMTVSQ TCIQQEYRLL 310 320 330 340 AEQYQLSISE AKQLLLNSIA AAFLSNEDKK ALLAHIQQRY PQLI

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP95347.1.
RefSeq	NP_872958.1.
3D structure databases
SMR	Q7VNV1. Positions 10-340.
ModBase	Search...
Genome annotation databases
GeneID	1490376.
GenomeReviews	Gene locus HD_0377 in contig AE017143_GR.
KEGG	hdu:HD0377.
NMPDR	fig|233412.1.peg.323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	KPGYAEL.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_0377-MONOMER.
BRENDA	3.5.4.4. 265031.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_HAEDU

Accession

Primary (citable) accession number: Q7VNV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
Last sequence update:	October 1, 2003
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)