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Q7VNI8 (NAGZ_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:HD_0542
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000210788

Regions

Region162 – 1632Substrate binding By similarity

Sites

Active site1751Proton donor/acceptor By similarity
Active site2471Nucleophile By similarity
Binding site601Substrate By similarity
Binding site681Substrate By similarity
Binding site1321Substrate By similarity
Site1731Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VNI8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 14F5BB166A559689

FASTA34438,985
        10         20         30         40         50         60 
MLIIDIKGTE ISQQEIEILS HPLVAGLILF SRNFVDKAQL TALIKEIRQK VTKPLLITID 

        70         80         90        100        110        120 
QEGGRVQRFR EGFTRLPAMQ AFGQLAKHPQ EAIIWAKQAG WLMAAEMFAL DIDLSFAPVL 

       130        140        150        160        170        180 
DLGHKCKAIG DRSFGEKVTQ ILPIAEGFID GMREIGMATT GKHFPGHGQV IADSHLETPF 

       190        200        210        220        230        240 
DERAKANIFN YDIQPFEYFI AKNKLSAIMP AHVVYTQCDP HPASGSTYWL QQVLRQQLQF 

       250        260        270        280        290        300 
KGIIFSDDLG MQGANLMGNF LQRSEQAINA GCDLLLLCNQ PEGVIEVLNG LTYQPNKLEQ 

       310        320        330        340 
QKYLTLKKRR TIDFQQLASS PRYQQTKQHL EQLHECWLEW QTTH 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP95482.1.
RefSeqNP_873093.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VNI8.
SMRQ7VNI8. Positions 2-337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD0542.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP95482; AAP95482; HD_0542.
GeneID1490520.
KEGGhdu:HD0542.
PATRIC20177577. VBIHaeDuc133973_0444.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
KOK01207.
OMAMGSYPER.
OrthoDBEOG6BCT06.
ProtClustDBPRK05337.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-498-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGZ_HAEDU
AccessionPrimary (citable) accession number: Q7VNI8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries