Q7VNI8 (NAGZ_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	HD_0542

Organism

Haemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]

Taxonomic identifier

233412 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus ducreyi

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity. HAMAP-Rule MF_00364
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Beta-hexosaminidase HAMAP-Rule MF_00364		PRO_0000210788
Sites
	Active site	247	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VNI8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 14F5BB166A559689	FASTA	344	38,985
	10 20 30 40 50 60 MLIIDIKGTE ISQQEIEILS HPLVAGLILF SRNFVDKAQL TALIKEIRQK VTKPLLITID 70 80 90 100 110 120 QEGGRVQRFR EGFTRLPAMQ AFGQLAKHPQ EAIIWAKQAG WLMAAEMFAL DIDLSFAPVL 130 140 150 160 170 180 DLGHKCKAIG DRSFGEKVTQ ILPIAEGFID GMREIGMATT GKHFPGHGQV IADSHLETPF 190 200 210 220 230 240 DERAKANIFN YDIQPFEYFI AKNKLSAIMP AHVVYTQCDP HPASGSTYWL QQVLRQQLQF 250 260 270 280 290 300 KGIIFSDDLG MQGANLMGNF LQRSEQAINA GCDLLLLCNQ PEGVIEVLNG LTYQPNKLEQ 310 320 330 340 QKYLTLKKRR TIDFQQLASS PRYQQTKQHL EQLHECWLEW QTTH

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP95482.1.
RefSeq	NP_873093.1. NC_002940.2.
3D structure databases
ProteinModelPortal	Q7VNI8.
SMR	Q7VNI8. Positions 2-337.
ModBase	Search...
Protein-protein interaction databases
STRING	233412.HD0542.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAP95482; AAP95482; HD_0542.
GeneID	1490520.
KEGG	hdu:HD0542.
PATRIC	20177577. VBIHaeDuc133973_0444.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1472.
KO	K01207.
OMA	FHEDPAI.
ProtClustDB	PRK05337.
Enzyme and pathway databases
BioCyc	HDUC233412:GH5F-474-MONOMER.
UniPathway	UPA00544.
Family and domain databases
Gene3D	3.20.20.300. 1 hit.
HAMAP	MF_00364. NagZ.
InterPro	IPR022956. Beta_hexosaminidase_bac. IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_HAEDU

Accession

Primary (citable) accession number: Q7VNI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program