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Q7VNI8

- NAGZ_HAEDU

UniProt

Q7VNI8 - NAGZ_HAEDU

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601SubstrateUniRule annotation
    Binding sitei68 – 681SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei173 – 1731Important for catalytic activityUniRule annotation
    Active sitei175 – 1751Proton donor/acceptorUniRule annotation
    Active sitei247 – 2471NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-498-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:HD_0542
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Beta-hexosaminidasePRO_0000210788Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233412.HD0542.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VNI8.
    SMRiQ7VNI8. Positions 2-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni162 – 1632Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    KOiK01207.
    OMAiYTEADPR.
    OrthoDBiEOG6BCT06.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VNI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIIDIKGTE ISQQEIEILS HPLVAGLILF SRNFVDKAQL TALIKEIRQK    50
    VTKPLLITID QEGGRVQRFR EGFTRLPAMQ AFGQLAKHPQ EAIIWAKQAG 100
    WLMAAEMFAL DIDLSFAPVL DLGHKCKAIG DRSFGEKVTQ ILPIAEGFID 150
    GMREIGMATT GKHFPGHGQV IADSHLETPF DERAKANIFN YDIQPFEYFI 200
    AKNKLSAIMP AHVVYTQCDP HPASGSTYWL QQVLRQQLQF KGIIFSDDLG 250
    MQGANLMGNF LQRSEQAINA GCDLLLLCNQ PEGVIEVLNG LTYQPNKLEQ 300
    QKYLTLKKRR TIDFQQLASS PRYQQTKQHL EQLHECWLEW QTTH 344
    Length:344
    Mass (Da):38,985
    Last modified:October 1, 2003 - v1
    Checksum:i14F5BB166A559689
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95482.1.
    RefSeqiNP_873093.1. NC_002940.2.
    WP_010944535.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP95482; AAP95482; HD_0542.
    GeneIDi1490520.
    KEGGihdu:HD0542.
    PATRICi20177577. VBIHaeDuc133973_0444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95482.1 .
    RefSeqi NP_873093.1. NC_002940.2.
    WP_010944535.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VNI8.
    SMRi Q7VNI8. Positions 2-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD0542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP95482 ; AAP95482 ; HD_0542 .
    GeneIDi 1490520.
    KEGGi hdu:HD0542.
    PATRICi 20177577. VBIHaeDuc133973_0444.

    Phylogenomic databases

    eggNOGi COG1472.
    KOi K01207.
    OMAi YTEADPR.
    OrthoDBi EOG6BCT06.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci HDUC233412:GH5F-498-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiNAGZ_HAEDU
    AccessioniPrimary (citable) accession number: Q7VNI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3