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Q7VNC2 (AROQ_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase

Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type II DHQase
Gene names
Name:aroQ
Ordered Locus Names:HD_0632
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00169

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169

Subunit structure

Homododecamer By similarity. HAMAP-Rule MF_00169

Sequence similarities

Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1441443-dehydroquinate dehydratase HAMAP-Rule MF_00169
PRO_0000159902

Regions

Region101 – 1022Substrate binding By similarity

Sites

Active site231Proton acceptor By similarity
Active site1001Proton donor By similarity
Binding site741Substrate By similarity
Binding site801Substrate By similarity
Binding site871Substrate By similarity
Binding site1111Substrate By similarity
Site181Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VNC2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3832A2A25C1B8C81

FASTA14416,141
        10         20         30         40         50         60 
MQNILLLNGP NLNMLGKREP HIYGDQTLLE IEQRLKQQAI KQGYNLLCFQ ANGEEAIINR 

        70         80         90        100        110        120 
IHQAFGNIDF IIINPAAFTH TSIAIRDALL AVAIPFIEVH LSNICSRESF RHHSYFSDIS 

       130        140 
QGIICGLGPK GYDYALDFAI SSLK 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP95558.1.
RefSeqNP_873169.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VNC2.
SMRQ7VNC2. Positions 1-144.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD0632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP95558; AAP95558; HD_0632.
GeneID1490603.
KEGGhdu:HD0632.
PATRIC20177729. VBIHaeDuc133973_0516.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0757.
KOK03786.
OMARREPGHY.
OrthoDBEOG66MQVT.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-581-MONOMER.
UniPathwayUPA00053; UER00086.

Family and domain databases

Gene3D3.40.50.9100. 1 hit.
HAMAPMF_00169. AroQ.
InterProIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERPTHR21272. PTHR21272. 1 hit.
PfamPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFPIRSF001399. DHquinase_II. 1 hit.
ProDomPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF52304. SSF52304. 1 hit.
TIGRFAMsTIGR01088. aroQ. 1 hit.
PROSITEPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROQ_HAEDU
AccessionPrimary (citable) accession number: Q7VNC2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways