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Q7VNC2

- AROQ_HAEDU

UniProt

Q7VNC2 - AROQ_HAEDU

Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes a trans-dehydration via an enolate intermediate.UniRule annotation

    Catalytic activityi

    3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei18 – 181Transition state stabilizerUniRule annotation
    Active sitei23 – 231Proton acceptorUniRule annotation
    Binding sitei74 – 741SubstrateUniRule annotation
    Binding sitei80 – 801SubstrateUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Active sitei100 – 1001Proton donorUniRule annotation
    Binding sitei111 – 1111SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-581-MONOMER.
    UniPathwayiUPA00053; UER00086.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
    Short name:
    3-dehydroquinaseUniRule annotation
    Alternative name(s):
    Type II DHQaseUniRule annotation
    Gene namesi
    Name:aroQUniRule annotation
    Ordered Locus Names:HD_0632
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1441443-dehydroquinate dehydratasePRO_0000159902Add
    BLAST

    Interactioni

    Subunit structurei

    Homododecamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi233412.HD0632.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VNC2.
    SMRiQ7VNC2. Positions 1-144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 1022Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the type-II 3-dehydroquinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0757.
    KOiK03786.
    OMAiRREPGHY.
    OrthoDBiEOG66MQVT.

    Family and domain databases

    Gene3Di3.40.50.9100. 1 hit.
    HAMAPiMF_00169. AroQ.
    InterProiIPR001874. DHquinase_II.
    IPR018509. DHquinase_II_CS.
    [Graphical view]
    PANTHERiPTHR21272. PTHR21272. 1 hit.
    PfamiPF01220. DHquinase_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001399. DHquinase_II. 1 hit.
    ProDomiPD004527. DHquinase_II. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF52304. SSF52304. 1 hit.
    TIGRFAMsiTIGR01088. aroQ. 1 hit.
    PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VNC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNILLLNGP NLNMLGKREP HIYGDQTLLE IEQRLKQQAI KQGYNLLCFQ    50
    ANGEEAIINR IHQAFGNIDF IIINPAAFTH TSIAIRDALL AVAIPFIEVH 100
    LSNICSRESF RHHSYFSDIS QGIICGLGPK GYDYALDFAI SSLK 144
    Length:144
    Mass (Da):16,141
    Last modified:October 1, 2003 - v1
    Checksum:i3832A2A25C1B8C81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95558.1.
    RefSeqiNP_873169.1. NC_002940.2.
    WP_010944611.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP95558; AAP95558; HD_0632.
    GeneIDi1490603.
    KEGGihdu:HD0632.
    PATRICi20177729. VBIHaeDuc133973_0516.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95558.1 .
    RefSeqi NP_873169.1. NC_002940.2.
    WP_010944611.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VNC2.
    SMRi Q7VNC2. Positions 1-144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD0632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP95558 ; AAP95558 ; HD_0632 .
    GeneIDi 1490603.
    KEGGi hdu:HD0632.
    PATRICi 20177729. VBIHaeDuc133973_0516.

    Phylogenomic databases

    eggNOGi COG0757.
    KOi K03786.
    OMAi RREPGHY.
    OrthoDBi EOG66MQVT.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00086 .
    BioCyci HDUC233412:GH5F-581-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.9100. 1 hit.
    HAMAPi MF_00169. AroQ.
    InterProi IPR001874. DHquinase_II.
    IPR018509. DHquinase_II_CS.
    [Graphical view ]
    PANTHERi PTHR21272. PTHR21272. 1 hit.
    Pfami PF01220. DHquinase_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001399. DHquinase_II. 1 hit.
    ProDomi PD004527. DHquinase_II. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF52304. SSF52304. 1 hit.
    TIGRFAMsi TIGR01088. aroQ. 1 hit.
    PROSITEi PS01029. DEHYDROQUINASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiAROQ_HAEDU
    AccessioniPrimary (citable) accession number: Q7VNC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3