Q7VNC2 (AROQ_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	HD_0632

Organism

Haemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]

Taxonomic identifier

233412 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus ducreyi

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP-Rule MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00169
Subunit structure	Homododecamer By similarity.
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	3-dehydroquinate dehydratase HAMAP-Rule MF_00169		PRO_0000159902
Regions
	Region	101 – 102	2	Substrate binding By similarity
Sites
	Active site	23	1	Proton acceptor By similarity
	Active site	100	1	Proton donor By similarity
	Binding site	74	1	Substrate By similarity
	Binding site	80	1	Substrate By similarity
	Binding site	87	1	Substrate By similarity
	Binding site	111	1	Substrate By similarity
	Site	18	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VNC2 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 3832A2A25C1B8C81	FASTA	144	16,141
	10 20 30 40 50 60 MQNILLLNGP NLNMLGKREP HIYGDQTLLE IEQRLKQQAI KQGYNLLCFQ ANGEEAIINR 70 80 90 100 110 120 IHQAFGNIDF IIINPAAFTH TSIAIRDALL AVAIPFIEVH LSNICSRESF RHHSYFSDIS 130 140 QGIICGLGPK GYDYALDFAI SSLK

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP95558.1.
RefSeq	NP_873169.1. NC_002940.2.
3D structure databases
ProteinModelPortal	Q7VNC2.
SMR	Q7VNC2. Positions 1-144.
ModBase	Search...
Protein-protein interaction databases
STRING	233412.HD0632.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAP95558; AAP95558; HD_0632.
GeneID	1490603.
KEGG	hdu:HD0632.
PATRIC	20177729. VBIHaeDuc133973_0516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0757.
KO	K03786.
OMA	RREPGHY.
ProtClustDB	PRK05395.
Enzyme and pathway databases
BioCyc	HDUC233412:GH5F-552-MONOMER.
UniPathway	UPA00053; UER00086.
Family and domain databases
Gene3D	3.40.50.9100. 1 hit.
HAMAP	MF_00169. AroQ.
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
PANTHER	PTHR21272. PTHR21272. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_HAEDU

Accession

Primary (citable) accession number: Q7VNC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2004
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program