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Q7VNC2

- AROQ_HAEDU

UniProt

Q7VNC2 - AROQ_HAEDU

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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.UniRule annotation

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei18 – 181Transition state stabilizerUniRule annotation
Active sitei23 – 231Proton acceptorUniRule annotation
Binding sitei74 – 741SubstrateUniRule annotation
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Active sitei100 – 1001Proton donorUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-581-MONOMER.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type II DHQaseUniRule annotation
Gene namesi
Name:aroQUniRule annotation
Ordered Locus Names:HD_0632
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1441443-dehydroquinate dehydratasePRO_0000159902Add
BLAST

Interactioni

Subunit structurei

Homododecamer.UniRule annotation

Protein-protein interaction databases

STRINGi233412.HD0632.

Structurei

3D structure databases

ProteinModelPortaliQ7VNC2.
SMRiQ7VNC2. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1022Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0757.
KOiK03786.
OMAiRREPGHY.
OrthoDBiEOG66MQVT.

Family and domain databases

Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VNC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNILLLNGP NLNMLGKREP HIYGDQTLLE IEQRLKQQAI KQGYNLLCFQ
60 70 80 90 100
ANGEEAIINR IHQAFGNIDF IIINPAAFTH TSIAIRDALL AVAIPFIEVH
110 120 130 140
LSNICSRESF RHHSYFSDIS QGIICGLGPK GYDYALDFAI SSLK
Length:144
Mass (Da):16,141
Last modified:October 1, 2003 - v1
Checksum:i3832A2A25C1B8C81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95558.1.
RefSeqiNP_873169.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95558; AAP95558; HD_0632.
GeneIDi1490603.
KEGGihdu:HD0632.
PATRICi20177729. VBIHaeDuc133973_0516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95558.1 .
RefSeqi NP_873169.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VNC2.
SMRi Q7VNC2. Positions 1-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD0632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95558 ; AAP95558 ; HD_0632 .
GeneIDi 1490603.
KEGGi hdu:HD0632.
PATRICi 20177729. VBIHaeDuc133973_0516.

Phylogenomic databases

eggNOGi COG0757.
KOi K03786.
OMAi RREPGHY.
OrthoDBi EOG66MQVT.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00086 .
BioCyci HDUC233412:GH5F-581-MONOMER.

Family and domain databases

Gene3Di 3.40.50.9100. 1 hit.
HAMAPi MF_00169. AroQ.
InterProi IPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view ]
PANTHERi PTHR21272. PTHR21272. 1 hit.
Pfami PF01220. DHquinase_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF001399. DHquinase_II. 1 hit.
ProDomi PD004527. DHquinase_II. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF52304. SSF52304. 1 hit.
TIGRFAMsi TIGR01088. aroQ. 1 hit.
PROSITEi PS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiAROQ_HAEDU
AccessioniPrimary (citable) accession number: Q7VNC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3