Q7VN43 (MUTL_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	HD_0743

Organism

Haemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]

Taxonomic identifier

233412 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 598	598	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_0000177946

Sequences

	Sequence		Length	Mass (Da)
	Q7VN43 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 56BC023B2931A70A	FASTA	598	66,728
	10 20 30 40 50 60 MTQHLIHILP PQLANQIAAG EVVERPASVV KELVENSLDA GANHIQIDIE KGGAQLIRLR 70 80 90 100 110 120 DNGCGIAKQD LTLALTRHAT SKIATLADLE MILSLGFRGE ALASISSVSR LTLTSRTANQ 130 140 150 160 170 180 TEAWQAYTQG REMNVEIQPA SHPVGTTIEV ANLFFNTPAR RKFLRTDKTE FNHIDEVVRR 190 200 210 220 230 240 IALAKPTISF TLTHNGKIIR QYRKVADQSV AQQQKRVAAI CGNHFLQQAT HIEWQHGDLH 250 260 270 280 290 300 LYGWVSSPQL ARPQNDLSYS YVNGRVMRDK IINHAVRQAY AELIPTGDQP AFILFLDLNP 310 320 330 340 350 360 TELDVNVHPA KHEVRFHQAR LIHGFILQGV QNALQAQLAL TPTDNQTDSV AETKACYTAD 370 380 390 400 410 420 NNRAAAGSNI FSSTPYPRYS GATNRPTKTA QQCYAELINT DKNDNANVAP IIYAEPLTTQ 430 440 450 460 470 480 ATPAITETAD PYPHHSQVLA LVENKALLLK EQEHFYVVPL KKLAQLQLTL SLAEKKSQPL 490 500 510 520 530 540 LIPLSLSLDQ AQAERWQQYQ AQLLDSGFEI KQKHWQGQTR LSIIAVPQCL RQQNLQQLLL 550 560 570 580 590 QLFNQHTDDL ADFFAKNSEL MTTYSLPEGT RLIANIEQQA KTQLADLKLA VDFSAYLT

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP95653.1.
RefSeq	NP_873264.1. NC_002940.2.
3D structure databases
ProteinModelPortal	Q7VN43.
SMR	Q7VN43. Positions 6-335.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1490699.
GenomeReviews	Gene locus HD_0743 in contig AE017143_GR.
KEGG	hdu:HD0743.
NMPDR	fig|233412.1.peg.629.
PATRIC	20177909. VBIHaeDuc133973_0605.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG520262.
OMA	EVANLFF.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_0743-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_HAEDU

Accession

Primary (citable) accession number: Q7VN43

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program