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Q7VN18

- TRMB_HAEDU

UniProt

Q7VN18 - TRMB_HAEDU

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, HD_0775
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 791S-adenosyl-L-methionine By similarity
Binding sitei104 – 1041S-adenosyl-L-methionine By similarity
Binding sitei131 – 1311S-adenosyl-L-methionine By similarity
Active sitei154 – 1541 By similarity
Binding sitei154 – 1541S-adenosyl-L-methionine By similarity
Binding sitei158 – 1581Substrate By similarity
Binding sitei190 – 1901Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-705-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:HD_0775
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD0775.

Structurei

3D structure databases

ProteinModelPortaliQ7VN18.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni228 – 2314Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VN18-1 [UniParc]FASTAAdd to Basket

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MSEKYTFADQ KRKTVEQAEF TEDGRYLRKV RSFVLRTGRL SDFQRDMMND    50
HWAKFGLDYQ KSPFDFVEIF GNANPVVLEI GFGMGRSLVE MAAQNPDRNY 100
IGIEVHTPGV GACIAYAVEK QVDNLRVICH DATEILRDAV ADGSLAGLQL 150
YFPDPWQKSK HHKRRIVQTE FVMRLLTKLT AGGFIHFATD WQNYAEHMLA 200
VLRQFSPALV NTSPTGDFID RPAFRPLTKF EARGQRLGHA VWDLYFVKK 249
Length:249
Mass (Da):28,597
Last modified:October 1, 2003 - v1
Checksum:i2040841D405DC489
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95680.1.
RefSeqiNP_873291.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95680; AAP95680; HD_0775.
GeneIDi1490727.
KEGGihdu:HD0775.
PATRICi20177965. VBIHaeDuc133973_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95680.1 .
RefSeqi NP_873291.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VN18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD0775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95680 ; AAP95680 ; HD_0775 .
GeneIDi 1490727.
KEGGi hdu:HD0775.
PATRICi 20177965. VBIHaeDuc133973_0633.

Phylogenomic databases

eggNOGi COG0220.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HDUC233412:GH5F-705-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiTRMB_HAEDU
AccessioniPrimary (citable) accession number: Q7VN18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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