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Reviewed, UniProtKB/Swiss-Prot Q7VMZ4 (DSBD_HAEDU)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thiol:disulfide interchange protein dsbD
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
      Short name=Disulfide reductase
Gene names
Name: dsbD
Ordered Locus Names: HD_0807
OrganismHaemophilus ducreyi [Complete proteome] [HAMAP]
Taxonomic identifier730 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

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Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 573553Thiol:disulfide interchange protein dsbD HAMAP MF_00399
PRO_0000007375

Regions

Topological domain21 – 175155Periplasmic Potential
Transmembrane176 – 19621 Potential
Topological domain197 – 22731Cytoplasmic Potential
Transmembrane228 – 24821 Potential
Topological domain249 – 2513Periplasmic Potential
Transmembrane252 – 27221 Potential
Topological domain273 – 29220Cytoplasmic Potential
Transmembrane293 – 31321 Potential
Topological domain314 – 33118Periplasmic Potential
Transmembrane332 – 35221 Potential
Topological domain353 – 36513Cytoplasmic Potential
Transmembrane366 – 38621 Potential
Topological domain387 – 3937Periplasmic Potential
Transmembrane394 – 41421 Potential
Topological domain415 – 42511Cytoplasmic Potential
Transmembrane426 – 44621 Potential
Topological domain447 – 573127Periplasmic Potential
Domain440 – 573134Thioredoxin

Amino acid modifications

Disulfide bond121 ↔ 126Redox-active By similarity
Disulfide bond191 ↔ 313Redox-active By similarity
Disulfide bond490 ↔ 493Redox-active By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q7VMZ4-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2D1D3A9C7E3632D6

FASTA57363,070
        10         20         30         40         50         60 
MLKRFFLLLS SLLLVCNVQA GLFNNKPQYL TAAEAFIFSS SQQDGQLQLH WQIADGYYLY 

        70         80         90        100        110        120 
QKEIQLSAQN ATLGDVTFPT AEKYQDEFFG EVAIFRDQLK LPVKLTDLKE NPSLKIRYQG 

       130        140        150        160        170        180 
CTKGFCYPPE TVVIPLNPSL QGNNSANSAA LPSTIATPNA PQTELAENLS NNYLSIFGFL 

       190        200        210        220        230        240 
LLGIGLAFTP CVLPMLPLLS AIVIGHKNRP NTSRALLLSF TYVQGMALTY TLLGLTVAAI 

       250        260        270        280        290        300 
GLPFQVALQS PAVLISLAVL FTLLAASMFG LFEIRLPNTW QQKLNALSQQ QQGGAVGNVF 

       310        320        330        340        350        360 
IMGIIAGLVA SPCTSAPLSG ALLYVAQSGN LLIGGLALYL LALGMGLPLI LITVFGNQIL 

       370        380        390        400        410        420 
PKSGEWLFKV KTAFGFVMLA LPIFLISRIL PSHYEPFLWS TLALAFLGWL ISSLNYSTML 

       430        440        450        460        470        480 
KQAVRILLFI AFGLTAYPWA NLVWQTTSNT AQPTTPHLAM EKITSLTELE QKLTAYQGKK 

       490        500        510        520        530        540 
VMLDLYADWC VACKEFEKYT FTDPQVQQQL ATMAVLQIDM TKNSAENTAL MKHFNVLGLP 

       550        560        570 
TILFFDENGH EMTNVRITGF LTANQFLAWL NRL

« Hide

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References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

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Cross-references

Sequence databases

AE017143 Genomic DNA. Translation: AAP95707.1.
RefSeqNP_873318.1.

3D structure databases

HSSPHSSP built from PDB template 1JPE based on UniProtKB P36655.
ModBaseSearch...

Genome annotation databases

GeneID1490764.
GenomeReviewsGene locus HD_0807 in contig AE017143_GR.
KEGGhdu:HD0807.
NMPDRfig|233412.1.peg.683.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ7VMZ4.
OMAQ7VMZ4. LQQPWLL.

Enzyme and pathway databases

BioCycHDUC233412:HD_0807-MON.
BRENDA1.8.1.8. 265031.

Family and domain databases

HAMAPMF_00399.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM.
IPR017936. Thioredoxin-like.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDSBD_HAEDU
AccessionPrimary (citable) accession number: Q7VMZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents