Q7VMZ4 (DSBD_HAEDU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 66.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Thiol:disulfide interchange protein DsbD EC=1.8.1.8 Alternative name(s): Protein-disulfide reductase Short name=Disulfide reductase | ||||
| Gene names |
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| Organism | Haemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 233412 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Protein attributes
| Sequence length | 573 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity. HAMAP MF_00399 |
| Catalytic activity | Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399 |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00399. |
| Sequence similarities | Belongs to the thioredoxin family. DsbD subfamily. Contains 1 thioredoxin domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Potential | ||||||||
| Chain | 21 – 573 | 553 | Thiol:disulfide interchange protein DsbD HAMAP MF_00399 | PRO_0000007375 | |||||||
Regions | |||||||||||
| Topological domain | 21 – 175 | 155 | Periplasmic Potential | ||||||||
| Transmembrane | 176 – 196 | 21 | Helical; Potential | ||||||||
| Topological domain | 197 – 227 | 31 | Cytoplasmic Potential | ||||||||
| Transmembrane | 228 – 248 | 21 | Helical; Potential | ||||||||
| Topological domain | 249 – 251 | 3 | Periplasmic Potential | ||||||||
| Transmembrane | 252 – 272 | 21 | Helical; Potential | ||||||||
| Topological domain | 273 – 292 | 20 | Cytoplasmic Potential | ||||||||
| Transmembrane | 293 – 313 | 21 | Helical; Potential | ||||||||
| Topological domain | 314 – 331 | 18 | Periplasmic Potential | ||||||||
| Transmembrane | 332 – 352 | 21 | Helical; Potential | ||||||||
| Topological domain | 353 – 365 | 13 | Cytoplasmic Potential | ||||||||
| Transmembrane | 366 – 386 | 21 | Helical; Potential | ||||||||
| Topological domain | 387 – 393 | 7 | Periplasmic Potential | ||||||||
| Transmembrane | 394 – 414 | 21 | Helical; Potential | ||||||||
| Topological domain | 415 – 425 | 11 | Cytoplasmic Potential | ||||||||
| Transmembrane | 426 – 446 | 21 | Helical; Potential | ||||||||
| Topological domain | 447 – 573 | 127 | Periplasmic Potential | ||||||||
| Domain | 440 – 573 | 134 | Thioredoxin | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 121 ↔ 126 | Redox-active By similarity | |||||||||
| Disulfide bond | 191 ↔ 313 | Redox-active By similarity | |||||||||
| Disulfide bond | 490 ↔ 493 | Redox-active By similarity | |||||||||
Sequences
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References
| [1] | "The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017143 Genomic DNA. Translation: AAP95707.1. |
| RefSeq | NP_873318.1. NC_002940.2. |
3D structure databases | |
| ProteinModelPortal | Q7VMZ4. |
| SMR | Q7VMZ4. Positions 454-573. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1490764. |
| GenomeReviews | Gene locus HD_0807 in contig AE017143_GR. |
| KEGG | hdu:HD0807. |
| NMPDR | fig|233412.1.peg.683. |
| PATRIC | 20178041. VBIHaeDuc133973_0664. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG640883. |
| OMA | RYQVPGP. |
| ProtClustDB | PRK00293. |
Enzyme and pathway databases | |
| BioCyc | HDUC233412:HD_0807-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00399. DbsD. [Tree] |
| InterPro | IPR003834. Cyt_c_assmbl_TM_dom. IPR022910. Thiol_diS_interchange_DbsD. IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| KO | K04084. |
| PANTHER | PTHR10438. Trx. 1 hit. |
| Pfam | PF02683. DsbD. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view] |
| SUPFAM | SSF52833. Thiordxn-like_fd. 1 hit. |
| PROSITE | PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DSBD_HAEDU | ||||||||
| Accession | Primary (citable) accession number: Q7VMZ4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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