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Q7VMX4

- 6PGD_HAEDU

UniProt

Q7VMX4 - 6PGD_HAEDU

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041NADPBy similarity
    Binding sitei104 – 1041SubstrateBy similarity
    Active sitei185 – 1851Proton acceptorBy similarity
    Active sitei192 – 1921Proton donorBy similarity
    Binding sitei193 – 1931SubstrateBy similarity
    Binding sitei262 – 2621Substrate; via amide nitrogenBy similarity
    Binding sitei289 – 2891SubstrateBy similarity
    Binding sitei447 – 4471Substrate; shared with dimeric partnerBy similarity
    Binding sitei453 – 4531Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPBy similarity
    Nucleotide bindingi34 – 363NADPBy similarity
    Nucleotide bindingi76 – 783NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-763-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    Name:gnd
    Ordered Locus Names:HD_0833
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090040Add
    BLAST

    Proteomic databases

    PRIDEiQ7VMX4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi233412.HD0833.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VMX4.
    SMRiQ7VMX4. Positions 4-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Substrate bindingBy similarity
    Regioni188 – 1892Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0362.
    KOiK00033.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VMX4-1 [UniParc]FASTAAdd to Basket

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    MSIKGDIGVI GLAVMGQNLI LNMNDNGFKV VAYNRTASKV DEFLAGEAKD    50
    TNIIGAYSLE DLAAKLEKPR KIMLMVRAGE VVDQFIDALL PHLEAGDIII 100
    DGGNSNYPDT NRRTITLAEK GIRFIGTGVS GGEEGARHGP SIMPGGNEEA 150
    WPFVKPILQA ISAKTDKDEP CCDWVGKEGA GHFVKMVHNG IEYGDMQLIC 200
    EAYQFLKDGL GLNYEEMHAI FADWKNTELD SYLIDITADI LAYKDADGEP 250
    LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITEAVFARC VSAFKDQRVA 300
    VSQLFNKTIT PISDDKKEWI EAVRKALLAS KIISYAQGFM LIREASENFE 350
    WNINYGATAL LWREGCIIRS AFLGNIRDAY EANPGLVFLG SDPYFQNILQ 400
    SAMADWRKVV AKSIEIGIPM PCMAAAITFL DGYSSEHLPA NLLQAQRDYF 450
    GAHTYERTDK PRCSFFHTNW TGRGGNTAST TYDV 484
    Length:484
    Mass (Da):53,272
    Last modified:October 1, 2003 - v1
    Checksum:iBA23A9A770615B23
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95728.1.
    RefSeqiNP_873339.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP95728; AAP95728; HD_0833.
    GeneIDi1490785.
    KEGGihdu:HD0833.
    PATRICi20178083. VBIHaeDuc133973_0685.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95728.1 .
    RefSeqi NP_873339.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VMX4.
    SMRi Q7VMX4. Positions 4-475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD0833.

    Proteomic databases

    PRIDEi Q7VMX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP95728 ; AAP95728 ; HD_0833 .
    GeneIDi 1490785.
    KEGGi hdu:HD0833.
    PATRICi 20178083. VBIHaeDuc133973_0685.

    Phylogenomic databases

    eggNOGi COG0362.
    KOi K00033.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci HDUC233412:GH5F-763-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry namei6PGD_HAEDU
    AccessioniPrimary (citable) accession number: Q7VMX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3