Reviewed, UniProtKB/Swiss-Prot Q7VMX4 (6PGD_HAEDU)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Ordered Locus Names:	HD_0833

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090040

Sequences

	Sequence		Length	Mass (Da)
	Q7VMX4-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: BA23A9A770615B23	FASTA	484	53,272
	10 20 30 40 50 60 MSIKGDIGVI GLAVMGQNLI LNMNDNGFKV VAYNRTASKV DEFLAGEAKD TNIIGAYSLE 70 80 90 100 110 120 DLAAKLEKPR KIMLMVRAGE VVDQFIDALL PHLEAGDIII DGGNSNYPDT NRRTITLAEK 130 140 150 160 170 180 GIRFIGTGVS GGEEGARHGP SIMPGGNEEA WPFVKPILQA ISAKTDKDEP CCDWVGKEGA 190 200 210 220 230 240 GHFVKMVHNG IEYGDMQLIC EAYQFLKDGL GLNYEEMHAI FADWKNTELD SYLIDITADI 250 260 270 280 290 300 LAYKDADGEP LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITEAVFARC VSAFKDQRVA 310 320 330 340 350 360 VSQLFNKTIT PISDDKKEWI EAVRKALLAS KIISYAQGFM LIREASENFE WNINYGATAL 370 380 390 400 410 420 LWREGCIIRS AFLGNIRDAY EANPGLVFLG SDPYFQNILQ SAMADWRKVV AKSIEIGIPM 430 440 450 460 470 480 PCMAAAITFL DGYSSEHLPA NLLQAQRDYF GAHTYERTDK PRCSFFHTNW TGRGGNTAST TYDV

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP95728.1.
RefSeq	NP_873339.1.
3D structure databases
SMR	Q7VMX4. Positions 4-475.
ModBase	Search...
Genome annotation databases
GeneID	1490785.
GenomeReviews	Gene locus HD_0833 in contig AE017143_GR.
KEGG	hdu:HD0833.
NMPDR	fig|233412.1.peg.704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG286913.
OMA	GQKEAYD.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_0833-MONOMER.
BRENDA	1.1.1.44. 265031.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_HAEDU

Accession

Primary (citable) accession number: Q7VMX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2003
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)