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Q7VMX4

- 6PGD_HAEDU

UniProt

Q7VMX4 - 6PGD_HAEDU

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Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
gnd, HD_0833
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041NADP By similarity
Binding sitei104 – 1041Substrate By similarity
Active sitei185 – 1851Proton acceptor By similarity
Active sitei192 – 1921Proton donor By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity
Binding sitei289 – 2891Substrate By similarity
Binding sitei447 – 4471Substrate; shared with dimeric partner By similarity
Binding sitei453 – 4531Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADP By similarity
Nucleotide bindingi34 – 363NADP By similarity
Nucleotide bindingi76 – 783NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-763-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:HD_0833
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4844846-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090040Add
BLAST

Proteomic databases

PRIDEiQ7VMX4.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi233412.HD0833.

Structurei

3D structure databases

ProteinModelPortaliQ7VMX4.
SMRiQ7VMX4. Positions 4-475.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1323Substrate binding By similarity
Regioni188 – 1892Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VMX4-1 [UniParc]FASTAAdd to Basket

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MSIKGDIGVI GLAVMGQNLI LNMNDNGFKV VAYNRTASKV DEFLAGEAKD    50
TNIIGAYSLE DLAAKLEKPR KIMLMVRAGE VVDQFIDALL PHLEAGDIII 100
DGGNSNYPDT NRRTITLAEK GIRFIGTGVS GGEEGARHGP SIMPGGNEEA 150
WPFVKPILQA ISAKTDKDEP CCDWVGKEGA GHFVKMVHNG IEYGDMQLIC 200
EAYQFLKDGL GLNYEEMHAI FADWKNTELD SYLIDITADI LAYKDADGEP 250
LVEKILDTAG QKGTGKWTGI NALDFGIPLT LITEAVFARC VSAFKDQRVA 300
VSQLFNKTIT PISDDKKEWI EAVRKALLAS KIISYAQGFM LIREASENFE 350
WNINYGATAL LWREGCIIRS AFLGNIRDAY EANPGLVFLG SDPYFQNILQ 400
SAMADWRKVV AKSIEIGIPM PCMAAAITFL DGYSSEHLPA NLLQAQRDYF 450
GAHTYERTDK PRCSFFHTNW TGRGGNTAST TYDV 484
Length:484
Mass (Da):53,272
Last modified:October 1, 2003 - v1
Checksum:iBA23A9A770615B23
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95728.1.
RefSeqiNP_873339.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95728; AAP95728; HD_0833.
GeneIDi1490785.
KEGGihdu:HD0833.
PATRICi20178083. VBIHaeDuc133973_0685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95728.1 .
RefSeqi NP_873339.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VMX4.
SMRi Q7VMX4. Positions 4-475.
ModBasei Search...

Protein-protein interaction databases

STRINGi 233412.HD0833.

Proteomic databases

PRIDEi Q7VMX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95728 ; AAP95728 ; HD_0833 .
GeneIDi 1490785.
KEGGi hdu:HD0833.
PATRICi 20178083. VBIHaeDuc133973_0685.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci HDUC233412:GH5F-763-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry namei6PGD_HAEDU
AccessioniPrimary (citable) accession number: Q7VMX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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