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Q7VMW5

- LPXB_HAEDU

UniProt

Q7VMW5 - LPXB_HAEDU

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-772-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:HD_0846
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Lipid-A-disaccharide synthasePRO_0000190167Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233412.HD0846.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VMW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VMW5-1 [UniParc]FASTAAdd to Basket

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    MSKDSPLIAL VAGEISGDIL GAGLINALKI HYPNARFIGV AGPQMIQAGC    50
    QTLFDMEELA VMGLAEVVKH LPRLLKRRKQ VIQTMLQQQP DIFIGIDAPD 100
    FNLTIEQKLK AKGITTIHYV SPSVWAWRQD RIHKIKRATN LVLAFLPFEK 150
    AFYDRFNVAC RFIGHTMADA IALKPNRTEA CQILNIDENQ RYLAILAGSR 200
    ASEVDFLAEP FLKAALLLKQ KYPDLQCLVP LVNQQRIQQF EQIKARVAPS 250
    LPVKILKGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYKLKPTSYW 300
    LAKRLIKTKY ISLPNLLADD MLVPELIQDE CNPENLAWYL GNYLADDIDN 350
    KKQQNELKQR FTDLHKMIQC DADSKAAQAV IDLLANSDDQ 390
    Length:390
    Mass (Da):43,621
    Last modified:October 1, 2003 - v1
    Checksum:i2052E9E511834324
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95737.1.
    RefSeqiNP_873348.1. NC_002940.2.
    WP_010944787.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP95737; AAP95737; HD_0846.
    GeneIDi1490794.
    KEGGihdu:HD0846.
    PATRICi20178101. VBIHaeDuc133973_0694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95737.1 .
    RefSeqi NP_873348.1. NC_002940.2.
    WP_010944787.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VMW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD0846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP95737 ; AAP95737 ; HD_0846 .
    GeneIDi 1490794.
    KEGGi hdu:HD0846.
    PATRICi 20178101. VBIHaeDuc133973_0694.

    Phylogenomic databases

    eggNOGi COG0763.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci HDUC233412:GH5F-772-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiLPXB_HAEDU
    AccessioniPrimary (citable) accession number: Q7VMW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3