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Q7VMW5 (LPXB_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:HD_0846
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190167

Sequences

Sequence LengthMass (Da)Tools
Q7VMW5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2052E9E511834324

FASTA39043,621
        10         20         30         40         50         60 
MSKDSPLIAL VAGEISGDIL GAGLINALKI HYPNARFIGV AGPQMIQAGC QTLFDMEELA 

        70         80         90        100        110        120 
VMGLAEVVKH LPRLLKRRKQ VIQTMLQQQP DIFIGIDAPD FNLTIEQKLK AKGITTIHYV 

       130        140        150        160        170        180 
SPSVWAWRQD RIHKIKRATN LVLAFLPFEK AFYDRFNVAC RFIGHTMADA IALKPNRTEA 

       190        200        210        220        230        240 
CQILNIDENQ RYLAILAGSR ASEVDFLAEP FLKAALLLKQ KYPDLQCLVP LVNQQRIQQF 

       250        260        270        280        290        300 
EQIKARVAPS LPVKILKGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYKLKPTSYW 

       310        320        330        340        350        360 
LAKRLIKTKY ISLPNLLADD MLVPELIQDE CNPENLAWYL GNYLADDIDN KKQQNELKQR 

       370        380        390 
FTDLHKMIQC DADSKAAQAV IDLLANSDDQ 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP95737.1.
RefSeqNP_873348.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VMW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD0846.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP95737; AAP95737; HD_0846.
GeneID1490794.
KEGGhdu:HD0846.
PATRIC20178101. VBIHaeDuc133973_0694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
ProtClustDBPRK00025.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-772-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_HAEDU
AccessionPrimary (citable) accession number: Q7VMW5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways