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Q7VMW5

- LPXB_HAEDU

UniProt

Q7VMW5 - LPXB_HAEDU

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, HD_0846
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-772-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HD_0846
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthaseUniRule annotationPRO_0000190167Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD0846.

Structurei

3D structure databases

ProteinModelPortaliQ7VMW5.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VMW5-1 [UniParc]FASTAAdd to Basket

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MSKDSPLIAL VAGEISGDIL GAGLINALKI HYPNARFIGV AGPQMIQAGC    50
QTLFDMEELA VMGLAEVVKH LPRLLKRRKQ VIQTMLQQQP DIFIGIDAPD 100
FNLTIEQKLK AKGITTIHYV SPSVWAWRQD RIHKIKRATN LVLAFLPFEK 150
AFYDRFNVAC RFIGHTMADA IALKPNRTEA CQILNIDENQ RYLAILAGSR 200
ASEVDFLAEP FLKAALLLKQ KYPDLQCLVP LVNQQRIQQF EQIKARVAPS 250
LPVKILKGNA RQAMIAADAT LLASGTAALE AMLCKSPMVV GYKLKPTSYW 300
LAKRLIKTKY ISLPNLLADD MLVPELIQDE CNPENLAWYL GNYLADDIDN 350
KKQQNELKQR FTDLHKMIQC DADSKAAQAV IDLLANSDDQ 390
Length:390
Mass (Da):43,621
Last modified:October 1, 2003 - v1
Checksum:i2052E9E511834324
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95737.1.
RefSeqiNP_873348.1. NC_002940.2.
WP_010944787.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95737; AAP95737; HD_0846.
GeneIDi1490794.
KEGGihdu:HD0846.
PATRICi20178101. VBIHaeDuc133973_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95737.1 .
RefSeqi NP_873348.1. NC_002940.2.
WP_010944787.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VMW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD0846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95737 ; AAP95737 ; HD_0846 .
GeneIDi 1490794.
KEGGi hdu:HD0846.
PATRICi 20178101. VBIHaeDuc133973_0694.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HDUC233412:GH5F-772-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiLPXB_HAEDU
AccessioniPrimary (citable) accession number: Q7VMW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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