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Q7VMJ6 (CDD_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:HD_0979
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP-Rule MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP-Rule MF_01558

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3. HAMAP-Rule MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP-Rule MF_01558

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Cytidine deaminase HAMAP-Rule MF_01558
PRO_0000171652

Regions

Domain73 – 15078CMP/dCMP deaminase zinc-binding
Region97 – 993Substrate binding By similarity

Sites

Active site1121Proton donor By similarity
Metal binding1101Zinc; catalytic By similarity
Metal binding1371Zinc; catalytic By similarity
Metal binding1401Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VMJ6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EFFA772153474DA8

FASTA29932,477
        10         20         30         40         50         60 
MTMPTLSALQ HRLAQLAEQK NEPLTLAIIE QLKQQSYQGA LSAPLVQQFC QQFSLSKIEL 

        70         80         90        100        110        120 
GLGCVPIAAC YALTPVSHFC VGAVAIGLSG SFYFGANQEF AGIAMQQTVH AEQSAISHAW 

       130        140        150        160        170        180 
LAGEGAISDM VVNCTPCGHC RQFMNELNTA TTLQIHLPHR QHNTLQQYLI DAFGPKDLNI 

       190        200        210        220        230        240 
ANVLFDQQHI VLPLQGDALV QATIKEAQQA YAPYSQAVSA VALQVGEQII CGRYAENAAF 

       250        260        270        280        290 
NPSLLPLQSA LNYRRFLGLS DVAVSRVVMV EKRAVLSHYH MSKALAETAL GLTLEYIAV 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP95860.1.
RefSeqNP_873471.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VMJ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD0979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP95860; AAP95860; HD_0979.
GeneID1490921.
KEGGhdu:HD0979.
PATRIC20178329. VBIHaeDuc133973_0804.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
KOK01489.
OMANRSHAPY.
OrthoDBEOG6XDH25.
ProtClustDBPRK09027.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-899-MONOMER.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. SSF53927. 2 hits.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_HAEDU
AccessionPrimary (citable) accession number: Q7VMJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families