Reviewed, UniProtKB/Swiss-Prot Q7VMJ6 (CDD_HAEDU)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	HD_0979

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Cytidine deaminase HAMAP MF_01558		PRO_0000171652
Regions
	Region	97 – 99	3	Substrate binding By similarity
Sites
	Active site	112	1	Proton donor By similarity
	Metal binding	110	1	Zinc; catalytic By similarity
	Metal binding	137	1	Zinc; catalytic By similarity
	Metal binding	140	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VMJ6-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: EFFA772153474DA8	FASTA	299	32,477
	10 20 30 40 50 60 MTMPTLSALQ HRLAQLAEQK NEPLTLAIIE QLKQQSYQGA LSAPLVQQFC QQFSLSKIEL 70 80 90 100 110 120 GLGCVPIAAC YALTPVSHFC VGAVAIGLSG SFYFGANQEF AGIAMQQTVH AEQSAISHAW 130 140 150 160 170 180 LAGEGAISDM VVNCTPCGHC RQFMNELNTA TTLQIHLPHR QHNTLQQYLI DAFGPKDLNI 190 200 210 220 230 240 ANVLFDQQHI VLPLQGDALV QATIKEAQQA YAPYSQAVSA VALQVGEQII CGRYAENAAF 250 260 270 280 290 NPSLLPLQSA LNYRRFLGLS DVAVSRVVMV EKRAVLSHYH MSKALAETAL GLTLEYIAV

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP95860.1.
RefSeq	NP_873471.1.
3D structure databases
SMR	Q7VMJ6. Positions 9-299.
ModBase	Search...
Genome annotation databases
GeneID	1490921.
GenomeReviews	Gene locus HD_0979 in contig AE017143_GR.
KEGG	hdu:HD0979.
NMPDR	fig|233412.1.peg.836.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG591160.
OMA	NRSHAPY.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_0979-MONOMER.
BRENDA	3.5.4.5. 265031.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_HAEDU

Accession

Primary (citable) accession number: Q7VMJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 1, 2003
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)