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Q7VM66

- SYL_HAEDU

UniProt

Q7VM66 - SYL_HAEDU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1037-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:HD_1132
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 861861Leucine--tRNA ligasePRO_0000152022Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233412.HD1132.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VM66.
    SMRiQ7VM66. Positions 228-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VM66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQQYNPSAI ESKVQHFWEE NKVFKAVKDI TKEKYYCLSM LPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMIG KNVLQPMGWD AFGLPAEGAA VKNNTAPAKW 100
    TYENIEYMKN QLKVLGFSYD WDREITTCRP EYYKWEQWFF TELYKKGLVY 150
    KKTSTVNWCP NDETVLANEQ VHEGCCWRCD TPVEQRDIPQ WFIKITDYAE 200
    ELLTQLDNLT QWPDQVKTMQ RNWIGRSEGV EITFKIAGSN ATLPVYTTRP 250
    DTFFGVSYLA VAAAHPLAEL ASTNNPALAE FIREAKNTKV AEAELATMEK 300
    KGMPTGLFAI HPLTGKEIPV WVANFVLMHY GTGAVMAVPA HDERDFDFAK 350
    KYGLQINQVI QPLDASTWDF SQAAFTEHGK LINSAEFDGL DFNHAFNAIA 400
    DKLESLGVGK RQVNFRLRDW GVSRQRYWGA PIPMMTTEQG EVVTVPLKDL 450
    PVILPENVVM DGVQSPIKSD PEWAKTTYEG QPALKETDTF DTFMESSWYY 500
    ARYTCPQYHQ GMLDADEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD 550
    AGILTSDEPA TKLLCQGMVL ADAFYYTSPT NERIWVSPTQ VSLERDEKGR 600
    IINATDPAGH KLVHSGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS 650
    PAEMTLEWQE SGVEGAKRFL GRVWNLVYEY VQQPATQALN ALELNKAQKE 700
    LRRDVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLNKAP LESDQDKAVM 750
    AEALSAVVRM LYPITPHICF ELWQALGNQQ TIDFAPWVVS DETAMIEDEK 800
    LVVVQVNGKV RGKITVPANA SEDEVKITAK NDANVAKFLA DMQIVKEIYI 850
    PFKMLNFVVK V 861
    Length:861
    Mass (Da):98,050
    Last modified:October 1, 2003 - v1
    Checksum:iE70ED792F8BCFB3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95994.1.
    RefSeqiNP_873605.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP95994; AAP95994; HD_1132.
    GeneIDi1491059.
    KEGGihdu:HD1132.
    PATRICi20178605. VBIHaeDuc133973_0940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP95994.1 .
    RefSeqi NP_873605.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VM66.
    SMRi Q7VM66. Positions 228-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD1132.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP95994 ; AAP95994 ; HD_1132 .
    GeneIDi 1491059.
    KEGGi hdu:HD1132.
    PATRICi 20178605. VBIHaeDuc133973_0940.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HDUC233412:GH5F-1037-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiSYL_HAEDU
    AccessioniPrimary (citable) accession number: Q7VM66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3