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Q7VM66

- SYL_HAEDU

UniProt

Q7VM66 - SYL_HAEDU

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Protein

Leucine--tRNA ligase

Gene
leuS, HD_1132
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1037-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:HD_1132
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligaseUniRule annotationPRO_0000152022Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD1132.

Structurei

3D structure databases

ProteinModelPortaliQ7VM66.
SMRiQ7VM66. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VM66-1 [UniParc]FASTAAdd to Basket

« Hide

MQQQYNPSAI ESKVQHFWEE NKVFKAVKDI TKEKYYCLSM LPYPSGRLHM    50
GHVRNYTIGD VISRYQRMIG KNVLQPMGWD AFGLPAEGAA VKNNTAPAKW 100
TYENIEYMKN QLKVLGFSYD WDREITTCRP EYYKWEQWFF TELYKKGLVY 150
KKTSTVNWCP NDETVLANEQ VHEGCCWRCD TPVEQRDIPQ WFIKITDYAE 200
ELLTQLDNLT QWPDQVKTMQ RNWIGRSEGV EITFKIAGSN ATLPVYTTRP 250
DTFFGVSYLA VAAAHPLAEL ASTNNPALAE FIREAKNTKV AEAELATMEK 300
KGMPTGLFAI HPLTGKEIPV WVANFVLMHY GTGAVMAVPA HDERDFDFAK 350
KYGLQINQVI QPLDASTWDF SQAAFTEHGK LINSAEFDGL DFNHAFNAIA 400
DKLESLGVGK RQVNFRLRDW GVSRQRYWGA PIPMMTTEQG EVVTVPLKDL 450
PVILPENVVM DGVQSPIKSD PEWAKTTYEG QPALKETDTF DTFMESSWYY 500
ARYTCPQYHQ GMLDADEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD 550
AGILTSDEPA TKLLCQGMVL ADAFYYTSPT NERIWVSPTQ VSLERDEKGR 600
IINATDPAGH KLVHSGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS 650
PAEMTLEWQE SGVEGAKRFL GRVWNLVYEY VQQPATQALN ALELNKAQKE 700
LRRDVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLNKAP LESDQDKAVM 750
AEALSAVVRM LYPITPHICF ELWQALGNQQ TIDFAPWVVS DETAMIEDEK 800
LVVVQVNGKV RGKITVPANA SEDEVKITAK NDANVAKFLA DMQIVKEIYI 850
PFKMLNFVVK V 861
Length:861
Mass (Da):98,050
Last modified:October 1, 2003 - v1
Checksum:iE70ED792F8BCFB3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95994.1.
RefSeqiNP_873605.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP95994; AAP95994; HD_1132.
GeneIDi1491059.
KEGGihdu:HD1132.
PATRICi20178605. VBIHaeDuc133973_0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP95994.1 .
RefSeqi NP_873605.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VM66.
SMRi Q7VM66. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD1132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP95994 ; AAP95994 ; HD_1132 .
GeneIDi 1491059.
KEGGi hdu:HD1132.
PATRICi 20178605. VBIHaeDuc133973_0940.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-1037-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiSYL_HAEDU
AccessioniPrimary (citable) accession number: Q7VM66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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