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Q7VM26

- LPXA_HAEDU

UniProt

Q7VM26 - LPXA_HAEDU

Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1083-MONOMER.
    UniPathwayiUPA00359; UER00477.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
    Short name:
    UDP-N-acetylglucosamine acyltransferaseUniRule annotation
    Gene namesi
    Name:lpxAUniRule annotation
    Ordered Locus Names:HD_1187
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferasePRO_0000188050Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi233412.HD1187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VM26.
    SMRiQ7VM26. Positions 3-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1043.
    KOiK00677.
    OMAiDCQDKKY.
    OrthoDBiEOG6F81P1.

    Family and domain databases

    Gene3Di1.20.1180.10. 1 hit.
    HAMAPiMF_00387. LpxA.
    InterProiIPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 3 hits.
    [Graphical view]
    PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VM26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLIDSTAKI SPLAVIEDGA QIGAHVEIGP FCVIGKNVKI DAKTILHSHV    50
    VINGHTEIGE QNQIFQFASI GEINQDLKYQ GEPTKVVIGD RNSIRESVTI 100
    HRGTVQGGGV TRIGNDNLFM INAHIAHDCN ISNHCIIANN GTLAGHVRLD 150
    DFVIVGGMSA IHQFVIIGSH VMLGGGSMVS QDVPPYVMAQ GNHAQPFGVN 200
    LEGLKRRGFD KPTMHAIRHV YKLIYRSGKT IEEVLPEIEH IALNEPAIKV 250
    YLDFFKHSTR GIIR 264
    Length:264
    Mass (Da):28,885
    Last modified:October 1, 2003 - v1
    Checksum:iA802464009D17982
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96037.1.
    RefSeqiNP_873648.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP96037; AAP96037; HD_1187.
    GeneIDi1491105.
    KEGGihdu:HD1187.
    PATRICi20178703. VBIHaeDuc133973_0989.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96037.1 .
    RefSeqi NP_873648.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VM26.
    SMRi Q7VM26. Positions 3-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD1187.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP96037 ; AAP96037 ; HD_1187 .
    GeneIDi 1491105.
    KEGGi hdu:HD1187.
    PATRICi 20178703. VBIHaeDuc133973_0989.

    Phylogenomic databases

    eggNOGi COG1043.
    KOi K00677.
    OMAi DCQDKKY.
    OrthoDBi EOG6F81P1.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00477 .
    BioCyci HDUC233412:GH5F-1083-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1180.10. 1 hit.
    HAMAPi MF_00387. LpxA.
    InterProi IPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiLPXA_HAEDU
    AccessioniPrimary (citable) accession number: Q7VM26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3