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Q7VLW6

- FTHS_HAEDU

UniProt

Q7VLW6 - FTHS_HAEDU

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, HD_1282
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1160-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:HD_1282
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199350Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD1282.

Structurei

3D structure databases

ProteinModelPortaliQ7VLW6.
SMRiQ7VLW6. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VLW6-1 [UniParc]FASTAAdd to Basket

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MKSDVEIAQS ATMQHINHIA EKLGLTVDQI EQYGKYKAKI NPADAFKLPA    50
KNGKLILVTA INPTPAGEGK TTVTIGLTDA LNHIGKQAVV AAREPSLGPV 100
FGVKGGAAGG GYAQVLPMED INLHFTGDFH AITSANNLLA ALLDNHIYQG 150
NALNIDPKRI LWRRVIDMND RQLRNILGGL GNTTDGVIRP DGFDITVASE 200
VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAQ GAMAALLKDA 250
IKPNLVQTMA GSPAFIHGGP FANIAHGCNS VIATRLALHL GDYAVTEAGF 300
GADLGAEKFC DIKCRLAELK PDVAVIVATV RALKYNGGVE KANLAEENLE 350
ALTEGLPNLL KHIANLKNVL GLPVVVALNR FVSDSDAELA LIQTACAKQG 400
VEVSLTEVWA RSAVGGVDLA HKVLKAIDEQ QNNFQFAYDV NDRIQHKITA 450
IAQKIYGATD VNFSAEALAE IKNLEKLALD KLPICMAKTQ YSLSDSAKLL 500
GCPTGFNITV RSITVSAGAG FIVAICGSIM RMPGLPKNPA TNRIDVDENG 550
VISGLF 556
Length:556
Mass (Da):59,166
Last modified:October 1, 2003 - v1
Checksum:i3160496053B0B9F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96104.1.
RefSeqiNP_873715.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96104; AAP96104; HD_1282.
GeneIDi1491182.
KEGGihdu:HD1282.
PATRICi20178865. VBIHaeDuc133973_1067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96104.1 .
RefSeqi NP_873715.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VLW6.
SMRi Q7VLW6. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD1282.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP96104 ; AAP96104 ; HD_1282 .
GeneIDi 1491182.
KEGGi hdu:HD1282.
PATRICi 20178865. VBIHaeDuc133973_1067.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci HDUC233412:GH5F-1160-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiFTHS_HAEDU
AccessioniPrimary (citable) accession number: Q7VLW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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