Q7VLW6 (FTHS_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	HD_1282

Organism

Haemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]

Taxonomic identifier

233412 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus ducreyi

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_0000199350
Regions
	Nucleotide binding	64 – 71	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VLW6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 3160496053B0B9F4	FASTA	556	59,166
	10 20 30 40 50 60 MKSDVEIAQS ATMQHINHIA EKLGLTVDQI EQYGKYKAKI NPADAFKLPA KNGKLILVTA 70 80 90 100 110 120 INPTPAGEGK TTVTIGLTDA LNHIGKQAVV AAREPSLGPV FGVKGGAAGG GYAQVLPMED 130 140 150 160 170 180 INLHFTGDFH AITSANNLLA ALLDNHIYQG NALNIDPKRI LWRRVIDMND RQLRNILGGL 190 200 210 220 230 240 GNTTDGVIRP DGFDITVASE VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAQ 250 260 270 280 290 300 GAMAALLKDA IKPNLVQTMA GSPAFIHGGP FANIAHGCNS VIATRLALHL GDYAVTEAGF 310 320 330 340 350 360 GADLGAEKFC DIKCRLAELK PDVAVIVATV RALKYNGGVE KANLAEENLE ALTEGLPNLL 370 380 390 400 410 420 KHIANLKNVL GLPVVVALNR FVSDSDAELA LIQTACAKQG VEVSLTEVWA RSAVGGVDLA 430 440 450 460 470 480 HKVLKAIDEQ QNNFQFAYDV NDRIQHKITA IAQKIYGATD VNFSAEALAE IKNLEKLALD 490 500 510 520 530 540 KLPICMAKTQ YSLSDSAKLL GCPTGFNITV RSITVSAGAG FIVAICGSIM RMPGLPKNPA 550 TNRIDVDENG VISGLF

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP96104.1.
RefSeq	NP_873715.1. NC_002940.2.
3D structure databases
ProteinModelPortal	Q7VLW6.
SMR	Q7VLW6. Positions 4-554.
ModBase	Search...
Protein-protein interaction databases
STRING	233412.HD1282.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAP96104; AAP96104; HD_1282.
GeneID	1491182.
KEGG	hdu:HD1282.
PATRIC	20178865. VBIHaeDuc133973_1067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
KO	K01938.
OMA	IIIGYNY.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	HDUC233412:GH5F-1113-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_HAEDU

Accession

Primary (citable) accession number: Q7VLW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program