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Q7VLW6

- FTHS_HAEDU

UniProt

Q7VLW6 - FTHS_HAEDU

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1160-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:HD_1282
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000199350Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233412.HD1282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VLW6.
    SMRiQ7VLW6. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VLW6-1 [UniParc]FASTAAdd to Basket

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    MKSDVEIAQS ATMQHINHIA EKLGLTVDQI EQYGKYKAKI NPADAFKLPA    50
    KNGKLILVTA INPTPAGEGK TTVTIGLTDA LNHIGKQAVV AAREPSLGPV 100
    FGVKGGAAGG GYAQVLPMED INLHFTGDFH AITSANNLLA ALLDNHIYQG 150
    NALNIDPKRI LWRRVIDMND RQLRNILGGL GNTTDGVIRP DGFDITVASE 200
    VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAQ GAMAALLKDA 250
    IKPNLVQTMA GSPAFIHGGP FANIAHGCNS VIATRLALHL GDYAVTEAGF 300
    GADLGAEKFC DIKCRLAELK PDVAVIVATV RALKYNGGVE KANLAEENLE 350
    ALTEGLPNLL KHIANLKNVL GLPVVVALNR FVSDSDAELA LIQTACAKQG 400
    VEVSLTEVWA RSAVGGVDLA HKVLKAIDEQ QNNFQFAYDV NDRIQHKITA 450
    IAQKIYGATD VNFSAEALAE IKNLEKLALD KLPICMAKTQ YSLSDSAKLL 500
    GCPTGFNITV RSITVSAGAG FIVAICGSIM RMPGLPKNPA TNRIDVDENG 550
    VISGLF 556
    Length:556
    Mass (Da):59,166
    Last modified:October 1, 2003 - v1
    Checksum:i3160496053B0B9F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96104.1.
    RefSeqiNP_873715.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP96104; AAP96104; HD_1282.
    GeneIDi1491182.
    KEGGihdu:HD1282.
    PATRICi20178865. VBIHaeDuc133973_1067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96104.1 .
    RefSeqi NP_873715.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VLW6.
    SMRi Q7VLW6. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD1282.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP96104 ; AAP96104 ; HD_1282 .
    GeneIDi 1491182.
    KEGGi hdu:HD1282.
    PATRICi 20178865. VBIHaeDuc133973_1067.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci HDUC233412:GH5F-1160-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiFTHS_HAEDU
    AccessioniPrimary (citable) accession number: Q7VLW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3