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Q7VLW6 (FTHS_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:HD_1282
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199350

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VLW6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3160496053B0B9F4

FASTA55659,166
        10         20         30         40         50         60 
MKSDVEIAQS ATMQHINHIA EKLGLTVDQI EQYGKYKAKI NPADAFKLPA KNGKLILVTA 

        70         80         90        100        110        120 
INPTPAGEGK TTVTIGLTDA LNHIGKQAVV AAREPSLGPV FGVKGGAAGG GYAQVLPMED 

       130        140        150        160        170        180 
INLHFTGDFH AITSANNLLA ALLDNHIYQG NALNIDPKRI LWRRVIDMND RQLRNILGGL 

       190        200        210        220        230        240 
GNTTDGVIRP DGFDITVASE VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAQ 

       250        260        270        280        290        300 
GAMAALLKDA IKPNLVQTMA GSPAFIHGGP FANIAHGCNS VIATRLALHL GDYAVTEAGF 

       310        320        330        340        350        360 
GADLGAEKFC DIKCRLAELK PDVAVIVATV RALKYNGGVE KANLAEENLE ALTEGLPNLL 

       370        380        390        400        410        420 
KHIANLKNVL GLPVVVALNR FVSDSDAELA LIQTACAKQG VEVSLTEVWA RSAVGGVDLA 

       430        440        450        460        470        480 
HKVLKAIDEQ QNNFQFAYDV NDRIQHKITA IAQKIYGATD VNFSAEALAE IKNLEKLALD 

       490        500        510        520        530        540 
KLPICMAKTQ YSLSDSAKLL GCPTGFNITV RSITVSAGAG FIVAICGSIM RMPGLPKNPA 

       550 
TNRIDVDENG VISGLF 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP96104.1.
RefSeqNP_873715.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VLW6.
SMRQ7VLW6. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD1282.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP96104; AAP96104; HD_1282.
GeneID1491182.
KEGGhdu:HD1282.
PATRIC20178865. VBIHaeDuc133973_1067.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-1160-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_HAEDU
AccessionPrimary (citable) accession number: Q7VLW6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways