Reviewed, UniProtKB/Swiss-Prot Q7VLN8 (ARGA_HAEDU)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	HD_1384

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm Probable.
Miscellaneous	In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (argJ), argA fulfills an anaplerotic role. HAMAP MF_01105
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186793
Regions
	Domain	289 – 437	149	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q7VLN8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 12CE064EDBADD241	FASTA	437	49,314
	10 20 30 40 50 60 MRNTELIEWF RQSAPYVNMH RHKTFVIMLD GNAIAHPNFI NITNDISLLH SLGIKLVIVF 70 80 90 100 110 120 GARCQIENLL KQNNISSSYH HNIRVTDSNM LEIIKQAVGG LHYDIFSRLS LRLPHSPVLN 130 140 150 160 170 180 VVSSNAILAQ PLGVIDGVDY GLSGKIRRIN IEAIQQQLAQ NAIVVIGPIA PSVTGKMFNL 190 200 210 220 230 240 AFEEIATQLA IKLKVDKLIA FCDRQGLLDE QGKVISDIHP REAKQHLKKF IQQGDYHHSA 250 260 270 280 290 300 ARFLQAAIDV CHAGIKRSHL ISYQTDGSLL QELFSRDGVG TQLSEASSEC IRLATSFDIA 310 320 330 340 350 360 GLLNLIRPLE DQGLLVKRSR EQLEMEISQY TIIERDGIVI ACAALIHYPA EKMAEMACVA 370 380 390 400 410 420 VHPDYRDSAR GDILLEAIKR RAYKLNIEKL FVLTTQTIQW FQERGFVQIQ PTDLPVEKQR 430 HYNYQRMSKV LMLALDN

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017143 Genomic DNA. Translation: AAP96197.1.
RefSeq	NP_873808.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1491276.
GenomeReviews	Gene locus HD_1384 in contig AE017143_GR.
KEGG	hdu:HD1384.
NMPDR	fig|233412.1.peg.1173.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VLN8.
OMA	DLIRPLE.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_1384-MON.
BRENDA	2.3.1.1. 265031.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_HAEDU

Accession

Primary (citable) accession number: Q7VLN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)