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Q7VLM3 (SYQ_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine--tRNA ligase

EC=6.1.1.18
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS
Gene names
Name:glnS
Ordered Locus Names:HD_1404
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). HAMAP-Rule MF_00126

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00126

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00126.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutaminyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

glutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Glutamine--tRNA ligase HAMAP-Rule MF_00126
PRO_0000195836

Regions

Motif39 – 4911"HIGH" region HAMAP-Rule MF_00126
Motif274 – 2785"KMSKS" region HAMAP-Rule MF_00126

Sites

Binding site2771ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VLM3 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 8317AA836D7092CC

FASTA55663,897
        10         20         30         40         50         60 
MSEETLTTEV ETRTNFITHI IDEDLASGKH NNVYTRFPPE PNGYLHIGHA KSICLNFGIA 

        70         80         90        100        110        120 
QEYHGKCNLR FDDTNPVKED IEYVASIKQD VEWLGFKWQG EPRYASDYFD QLHGYAIELI 

       130        140        150        160        170        180 
EKGLAYVDEL SPEEMREYRG TLTEAGKNSP YRDRSIAENL ALFEKMKNGE FKEGTACLRA 

       190        200        210        220        230        240 
KIDMASPFIV MRDPVLYRVK FAHHHQTGDK WCIYPMYDFT HCISDAIERI THSLCTLEFQ 

       250        260        270        280        290        300 
DNRRLYDWVL ENISIERPLP HQYEFSRLNL EGTLTSKRKL LQLVTDGIVD GWNDPRMPTI 

       310        320        330        340        350        360 
SGLRRRGYTP ASLREFCRRI GVTKQDNVVE YAALEACIRE DLNENAPRAM AVINPVRVVI 

       370        380        390        400        410        420 
ENVAEPEILK APNHPNRPEL GERDLPFTRE IYIDEADFRE EANKQYKRLV LGKEVRLRNA 

       430        440        450        460        470        480 
YVIKAERVEK DASGKITTIF CSYDPETLGK NPADGRKVKG VIHWVSATQN KVAEFRIYNR 

       490        500        510        520        530        540 
LFNVANPGDE EDINAVINPS SLIVKHGFVE VNLANAQKEQ GYQFEREGYY CLDSKEGSAD 

       550 
NLIFNLTVSL KEGFTA 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP96212.1.
RefSeqNP_873823.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VLM3.
SMRQ7VLM3. Positions 14-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD1404.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP96212; AAP96212; HD_1404.
GeneID1491292.
KEGGhdu:HD1404.
PATRIC20179080. VBIHaeDuc133973_1174.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
KOK01886.
OMASREIYID.
OrthoDBEOG6DRPF7.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-1270-MONOMER.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
HAMAPMF_00126. Gln_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR022861. Gln_tRNA_ligase_bac.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00440. glnS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYQ_HAEDU
AccessionPrimary (citable) accession number: Q7VLM3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries