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Q7VLG6 (BIOD1_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent dethiobiotin synthetase BioD 1

EC=6.3.3.3
Alternative name(s):
DTB synthetase 1
Short name=DTBS 1
Dethiobiotin synthase 1
Gene names
Name:bioD1
Ordered Locus Names:HD_1480
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring By similarity. HAMAP MF_00336

Catalytic activity

ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336

Cofactor

Magnesium By similarity. HAMAP MF_00336

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336

Subcellular location

Cytoplasm By similarity HAMAP MF_00336.

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
   Biological processBiotin biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbiotin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

dethiobiotin synthase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278ATP-dependent dethiobiotin synthetase BioD 1 HAMAP MF_00336
PRO_0000187967

Regions

Nucleotide binding51 – 566ATP By similarity
Nucleotide binding223 – 2242ATP By similarity
Nucleotide binding252 – 2543ATP By similarity

Sites

Metal binding511Magnesium 1 By similarity
Metal binding551Magnesium 2 By similarity
Metal binding1021Magnesium 2 By similarity
Metal binding1631Magnesium 2 By similarity
Binding site1021ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7VLG6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 8F93B3069BC6EF99

FASTA27831,444
        10         20         30         40         50         60 
MFSDKTRNLS RKFDQEHHYT LKKVLKYKQF CNYFVKRKKI PSLFITGTDT NVGKTIVTRA 

        70         80         90        100        110        120 
ILQVLAQHNF SVVGYKPIAC GGDDDLPTEP NQTDYTSEDN SDVLIILDSC PQPVAYRDIN 

       130        140        150        160        170        180 
SYTFTHSSTP IFAALDAVHH IQEEKLDTDL SNLQQNYPNV VVEGTYGWLT PINKDLSFAE 

       190        200        210        220        230        240 
WVHKNNMPAV LVVGIKEGCV NHALLTAQAI QQQGVNLIGW VANRINPCLR HYAELIELLS 

       250        260        270 
KKISAPLLGQ IPYIAQPHKK DLTSYIENPD PLLAYFQK 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP96282.1.
RefSeqNP_873893.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VLG6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1491363.
GenomeReviewsGene locus HD_1480 in contig AE017143_GR.
KEGGhdu:HD1480.
NMPDRfig|233412.1.peg.1258.
PATRIC20179208. VBIHaeDuc133973_1237.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG650065.
OMAINPGLSH.
ProtClustDBPRK00090.

Enzyme and pathway databases

BioCycHDUC233412:HD_1480-MONOMER.

Family and domain databases

HAMAPMF_00336. BioD. Divergent sequence.
[Tree]
InterProIPR002586. CbiA_P_synth.
IPR004472. DTB_synth_BioD.
[Graphical view]
KOK01935.
PfamPF01656. CbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00347. BioD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBIOD1_HAEDU
AccessionPrimary (citable) accession number: Q7VLG6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families