Reviewed, UniProtKB/Swiss-Prot Q7VLG6 (BIOD1_HAEDU)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase 1
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase 1
    DTB synthetase 1
      Short name=DTBS 1

Gene names

Name:	bioD1
Ordered Locus Names:	HD_1480

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Dethiobiotin synthetase 1 HAMAP MF_00336		PRO_0000187967
Regions
	Nucleotide binding	47 – 55	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VLG6-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8F93B3069BC6EF99	FASTA	278	31,444
	10 20 30 40 50 60 MFSDKTRNLS RKFDQEHHYT LKKVLKYKQF CNYFVKRKKI PSLFITGTDT NVGKTIVTRA 70 80 90 100 110 120 ILQVLAQHNF SVVGYKPIAC GGDDDLPTEP NQTDYTSEDN SDVLIILDSC PQPVAYRDIN 130 140 150 160 170 180 SYTFTHSSTP IFAALDAVHH IQEEKLDTDL SNLQQNYPNV VVEGTYGWLT PINKDLSFAE 190 200 210 220 230 240 WVHKNNMPAV LVVGIKEGCV NHALLTAQAI QQQGVNLIGW VANRINPCLR HYAELIELLS 250 260 270 KKISAPLLGQ IPYIAQPHKK DLTSYIENPD PLLAYFQK

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017143 Genomic DNA. Translation: AAP96282.1.
RefSeq	NP_873893.1.
3D structure databases
HSSP	HSSP built from PDB template 1DTS based on UniProtKB P13000.
ModBase	Search...
Genome annotation databases
GeneID	1491363.
GenomeReviews	Gene locus HD_1480 in contig AE017143_GR.
KEGG	hdu:HD1480.
NMPDR	fig|233412.1.peg.1258.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7VLG6.
OMA	ETPEGMR.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_1480-MON.
BRENDA	6.3.3.3. 265031.
Family and domain databases
HAMAP	MF_00336. Divergent sequence. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD1_HAEDU

Accession

Primary (citable) accession number: Q7VLG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)