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Q7VLE9

- GUAA_HAEDU

UniProt

Q7VLE9 - GUAA_HAEDU

Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of GMP from XMP.UniRule annotation

    Catalytic activityi

    ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851NucleophileUniRule annotation
    Active sitei179 – 1791UniRule annotation
    Active sitei181 – 1811UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi233 – 2397ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
    3. pyrophosphatase activity Source: InterPro

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-HAMAP
    2. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1358-MONOMER.
    UniPathwayiUPA00189; UER00296.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP synthase [glutamine-hydrolyzing]UniRule annotation (EC:6.3.5.2UniRule annotation)
    Alternative name(s):
    GMP synthetaseUniRule annotation
    Glutamine amidotransferaseUniRule annotation
    Gene namesi
    Name:guaAUniRule annotation
    Ordered Locus Names:HD_1504
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]PRO_0000140130Add
    BLAST

    Proteomic databases

    PRIDEiQ7VLE9.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi233412.HD1504.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VLE9.
    SMRiQ7VLE9. Positions 3-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 205198Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST
    Domaini206 – 398193GMPS ATP-PPaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation
    Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0519.
    KOiK01951.
    OMAiKIYGLQF.
    OrthoDBiEOG6JHRJV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_00344. GMP_synthase.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VLE9-1 [UniParc]FASTAAdd to Basket

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    MNNIHNHKIL ILDFGSQYTQ LIARRIREIG VYCELWAWDV TEKQIREFNP    50
    TGIILSGGPE STTETNSPHA PEYVFKAGVP VLGICYGMQT MAMQLGGLTE 100
    ASEQREFGYA AVELQHADQL FAKLNDDLTA SQPKLDVWMS HGDKVTRLPA 150
    GFQTTAVTPT CPIAAMSDEK RRFYGVQFHP EVTHTKSGLA LLTNFVENIC 200
    GCARSWTPEN IIEDAVAKIK QKVGNDQVIL GLSGGVDSSV TALLLHRAIG 250
    KNLHCVFVDN GLLRLNEGDQ VMEMFGDKFG LNIIRVNAEE RFLEALKGID 300
    EPEAKRKIIG KVFIDIFDDE AKKLTDVKWL AQGTIYPDVI ESAASKTGKA 350
    HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLTLG LPAEMLNRHP 400
    FPGPGLGVRV LGEIKKEYCD LLRNADAIFI EELYKSGWYY KVSQAFTVFL 450
    PVKSVGVMGD GRKYDWVVSL RAVETIDFMT AHWAHLPYEL LGKISNRIIN 500
    EVNGISRVVY DVSGKPPATI EWE 523
    Length:523
    Mass (Da):58,283
    Last modified:October 1, 2003 - v1
    Checksum:i590F209389B0B3EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96299.1.
    AF057695 Genomic DNA. Translation: AAC79759.1.
    PIRiT31103.
    RefSeqiNP_873910.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP96299; AAP96299; HD_1504.
    GeneIDi1491382.
    KEGGihdu:HD1504.
    PATRICi20179248. VBIHaeDuc133973_1257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96299.1 .
    AF057695 Genomic DNA. Translation: AAC79759.1 .
    PIRi T31103.
    RefSeqi NP_873910.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VLE9.
    SMRi Q7VLE9. Positions 3-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD1504.

    Proteomic databases

    PRIDEi Q7VLE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP96299 ; AAP96299 ; HD_1504 .
    GeneIDi 1491382.
    KEGGi hdu:HD1504.
    PATRICi 20179248. VBIHaeDuc133973_1257.

    Phylogenomic databases

    eggNOGi COG0519.
    KOi K01951.
    OMAi KIYGLQF.
    OrthoDBi EOG6JHRJV.

    Enzyme and pathway databases

    UniPathwayi UPA00189 ; UER00296 .
    BioCyci HDUC233412:GH5F-1358-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_00344. GMP_synthase.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.
    2. "Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein."
      Ward C.K., Lumbley S.R., Latimer J.L., Cope L.D., Hansen E.J.
      J. Bacteriol. 180:6013-6022(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 156-523.
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiGUAA_HAEDU
    AccessioniPrimary (citable) accession number: Q7VLE9
    Secondary accession number(s): Q9ZHL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3