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Q7VLE9

- GUAA_HAEDU

UniProt

Q7VLE9 - GUAA_HAEDU

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Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851NucleophileUniRule annotation
Active sitei179 – 1791UniRule annotation
Active sitei181 – 1811UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi233 – 2397ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
  3. pyrophosphatase activity Source: InterPro

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-HAMAP
  2. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1358-MONOMER.
UniPathwayiUPA00189; UER00296.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing]UniRule annotation (EC:6.3.5.2UniRule annotation)
Alternative name(s):
GMP synthetaseUniRule annotation
Glutamine amidotransferaseUniRule annotation
Gene namesi
Name:guaAUniRule annotation
Ordered Locus Names:HD_1504
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523GMP synthase [glutamine-hydrolyzing]PRO_0000140130Add
BLAST

Proteomic databases

PRIDEiQ7VLE9.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi233412.HD1504.

Structurei

3D structure databases

ProteinModelPortaliQ7VLE9.
SMRiQ7VLE9. Positions 3-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 205198Glutamine amidotransferase type-1UniRule annotationAdd
BLAST
Domaini206 – 398193GMPS ATP-PPaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation
Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0519.
KOiK01951.
OMAiKIYGLQF.
OrthoDBiEOG6JHRJV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VLE9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNIHNHKIL ILDFGSQYTQ LIARRIREIG VYCELWAWDV TEKQIREFNP
60 70 80 90 100
TGIILSGGPE STTETNSPHA PEYVFKAGVP VLGICYGMQT MAMQLGGLTE
110 120 130 140 150
ASEQREFGYA AVELQHADQL FAKLNDDLTA SQPKLDVWMS HGDKVTRLPA
160 170 180 190 200
GFQTTAVTPT CPIAAMSDEK RRFYGVQFHP EVTHTKSGLA LLTNFVENIC
210 220 230 240 250
GCARSWTPEN IIEDAVAKIK QKVGNDQVIL GLSGGVDSSV TALLLHRAIG
260 270 280 290 300
KNLHCVFVDN GLLRLNEGDQ VMEMFGDKFG LNIIRVNAEE RFLEALKGID
310 320 330 340 350
EPEAKRKIIG KVFIDIFDDE AKKLTDVKWL AQGTIYPDVI ESAASKTGKA
360 370 380 390 400
HVIKSHHNVG GLPDYMKLGL VEPLRELFKD EVRKIGLTLG LPAEMLNRHP
410 420 430 440 450
FPGPGLGVRV LGEIKKEYCD LLRNADAIFI EELYKSGWYY KVSQAFTVFL
460 470 480 490 500
PVKSVGVMGD GRKYDWVVSL RAVETIDFMT AHWAHLPYEL LGKISNRIIN
510 520
EVNGISRVVY DVSGKPPATI EWE
Length:523
Mass (Da):58,283
Last modified:October 1, 2003 - v1
Checksum:i590F209389B0B3EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96299.1.
AF057695 Genomic DNA. Translation: AAC79759.1.
PIRiT31103.
RefSeqiNP_873910.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96299; AAP96299; HD_1504.
GeneIDi1491382.
KEGGihdu:HD1504.
PATRICi20179248. VBIHaeDuc133973_1257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96299.1 .
AF057695 Genomic DNA. Translation: AAC79759.1 .
PIRi T31103.
RefSeqi NP_873910.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VLE9.
SMRi Q7VLE9. Positions 3-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233412.HD1504.

Proteomic databases

PRIDEi Q7VLE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP96299 ; AAP96299 ; HD_1504 .
GeneIDi 1491382.
KEGGi hdu:HD1504.
PATRICi 20179248. VBIHaeDuc133973_1257.

Phylogenomic databases

eggNOGi COG0519.
KOi K01951.
OMAi KIYGLQF.
OrthoDBi EOG6JHRJV.

Enzyme and pathway databases

UniPathwayi UPA00189 ; UER00296 .
BioCyci HDUC233412:GH5F-1358-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_00344. GMP_synthase.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.
  2. "Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein."
    Ward C.K., Lumbley S.R., Latimer J.L., Cope L.D., Hansen E.J.
    J. Bacteriol. 180:6013-6022(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 156-523.
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiGUAA_HAEDU
AccessioniPrimary (citable) accession number: Q7VLE9
Secondary accession number(s): Q9ZHL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3