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Q7VL96

- MUKB_HAEDU

UniProt

Q7VL96 - MUKB_HAEDU

Protein

Chromosome partition protein MukB

Gene

mukB

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome condensation Source: UniProtKB-KW
    4. chromosome segregation Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition, DNA condensation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1423-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromosome partition protein MukBUniRule annotation
    Alternative name(s):
    Structural maintenance of chromosome-related proteinUniRule annotation
    Gene namesi
    Name:mukBUniRule annotation
    Ordered Locus Names:HD_1582
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasmnucleoid UniRule annotation
    Note: Restricted to the nucleoid region.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-HAMAP
    2. nucleoid Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15031503Chromosome partition protein MukBPRO_0000068219Add
    BLAST

    Proteomic databases

    PRIDEiQ7VL96.

    Interactioni

    Subunit structurei

    Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.UniRule annotation

    Protein-protein interaction databases

    IntActiQ7VL96. 2 interactions.
    STRINGi233412.HD1582.

    Structurei

    Secondary structure

    1
    1503
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 4610
    Beta strandi49 – 557
    Beta strandi58 – 647
    Helixi71 – 8212
    Turni86 – 883
    Helixi109 – 1113
    Beta strandi114 – 12411
    Beta strandi130 – 13910
    Beta strandi143 – 1453
    Beta strandi151 – 1566
    Beta strandi159 – 1613
    Helixi163 – 1675
    Beta strandi168 – 1714
    Beta strandi174 – 1774
    Helixi180 – 1867
    Turni187 – 1893
    Helixi200 – 20910
    Beta strandi213 – 2153
    Helixi220 – 23415
    Helixi240 – 2445
    Helixi246 – 2483
    Turni255 – 2584
    Helixi259 – 2624
    Helixi1266 – 128621
    Helixi1287 – 12904
    Beta strandi1298 – 130710
    Helixi1309 – 132012
    Helixi1336 – 134611
    Helixi1363 – 13653
    Helixi1368 – 13703
    Beta strandi1372 – 13809
    Turni1381 – 13833
    Beta strandi1384 – 13874
    Helixi1390 – 13923
    Helixi1395 – 141622
    Beta strandi1418 – 14214
    Beta strandi1430 – 14356
    Helixi1436 – 14383
    Helixi1441 – 145313
    Beta strandi1457 – 14659
    Beta strandi1469 – 14757
    Beta strandi1478 – 14814
    Beta strandi1484 – 14874
    Beta strandi1490 – 14934

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EUJX-ray3.10A33-271[»]
    A1263-1496[»]
    3EUKX-ray4.00A/C/F/H33-271[»]
    A/C/F/H1263-1496[»]
    ProteinModelPortaliQ7VL96.
    SMRiQ7VL96. Positions 35-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7VL96.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni696 – 813118Flexible hingeUniRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili370 – 495126UniRule annotationAdd
    BLAST
    Coiled coili536 – 61681UniRule annotationAdd
    BLAST
    Coiled coili662 – 69736UniRule annotationAdd
    BLAST
    Coiled coili865 – 1173309UniRule annotationAdd
    BLAST
    Coiled coili1238 – 129356UniRule annotationAdd
    BLAST

    Domaini

    The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.UniRule annotation

    Sequence similaritiesi

    Belongs to the SMC family. MukB subfamily.UniRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG3096.
    KOiK03632.
    OMAiFALSDVM.
    OrthoDBiEOG62C98M.

    Family and domain databases

    HAMAPiMF_01800. MukB.
    InterProiIPR012090. MukB.
    IPR007406. MukB_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF04310. MukB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005246. MukB. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7VL96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMNTNELFDQ TAVNSSQDKP LNPPFAVAQP ANIARGKFRS LTLINWNGFF     50
    ARTFDFDELV TTLSGGNGAG KSTTMAGFVT ALIPDLTLLN FRNTTEAGST 100
    SSSRDKGLYG KLKAGVCYAV LETVNSRAQR IITGVRLQQI AGRDKKVDIR 150
    PFSLQNVPMA DSVISLFTEQ VANKARVLSL NDLKEKFEET AVTFKPYHSI 200
    TDYHSFMFDL GILPKRLRSS SDRNKFYKLI EASLYGGISS VITKSLRDYL 250
    LPENSGVRQA FQDMEAALRE NRMTLEAIKV TQSDRDMFKH LITEATQYVS 300
    ADYMRNANER RGNVVSALAQ RRTWYDTKAK LLVEEQRLIE FSREVADINL 350
    TEQSLESEYN VANDHLNLVM NALRHQEKII RYQDEVDALN EKLEQQQIAL 400
    EEVSEQVEDA QAHTDEIDDR VDGLRSQIAD YQQALDAQQT RALQYQQAIT 450
    ALQKAQQLCA LPHLDLDNLK DYQTEFEAQA QDITDHVFEL EQRLSISDMT 500
    KTQFEKAYQL VCKVSGEIDR SQAWSEATQL LATFPDQKMQ AAQAVALRQK 550
    LADLEQRLHQ QQKVQRLIAE FNQQAAKKLT DFTALENHFE QQQIKLEDLE 600
    AELANVIELR SVHRQQQEQL TQQYNQLAKT APAWHTARSV LTRLEEQCAE 650
    QFENSQAIMH CMQEMLRKER EATLERDELA RTEAALASQI SQLSQADGAE 700
    DIRLNQLAER LGGVLLSELY DDVSLQDAPY FSALYGEARH AIVVRDLTSV 750
    KAQLEKLTDC PNDLYLIEGD PTAFDDTVFS AEELYDSVIV KVSNRQWRYS 800
    KFPEVPLFGR AAREKHLITL KTERDDIAEQ HAESAFNVQK YQRLHQHLSQ 850
    FVGTHLNIAF QPDPEMLMQE IALERQEIEG QLNQAVENEH YLRQQADHLK 900
    AELQMLNKIL PLANTLADET VMERFEECRE QLQSAEENEL FVRQFGQYLT 950
    QLAPIATSLQ TDPSKFEQLE HDYQQAKSTQ RILQQKVFAL SDVMQRRLHF 1000
    NYSEENQCEG SALTEQLRTD LALAQQEREQ ARQRLRQAQA QFTQYNQVLI 1050
    SLRSAYDAKY QMLQELMQEI DDLGVRGDSA AEECARLRRD ELQQQLSQQR 1100
    ARKGYLDKQL GIIEAEIDNL NRLLRKTERD YQTQRELVVQ AKASWCLVQK 1150
    LSRNSDVEKR LNRRELAYQS AEELRSISDK ALGALRTAVA DNEYLRDSLR 1200
    ASEDSRKPEN KVAFFIAVYQ HLRERIRQDI IRTDDPIDAI EQMEIELSRL 1250
    INELTSREKK LAISAESVAN ILRKTIQREQ NRILQLNQGL QNIAFGQVKG 1300
    VRLVVNIRDT HSILLNALSD QHEQHKDLFE SQKLSFSEAL AMLYKRVNPH 1350
    IELGQRMPQT IGEELLDYRN YLDLEVETLR GADGWMRAES SALSTGEAIG 1400
    TGMSILLMVV QSWEEESRRM RAKDILPCRL LFLDEAARLD AMSINTLFEL 1450
    CERLDMQLLI AAPENISPEH GTTYKLVRKI LANQEYVHVV GLKGFGQQMN 1500
    KST 1503
    Length:1,503
    Mass (Da):172,403
    Last modified:October 1, 2003 - v1
    Checksum:i5C847ACCAE02F0EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96363.1.
    RefSeqiNP_873974.1. NC_002940.2.
    WP_010945395.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP96363; AAP96363; HD_1582.
    GeneIDi1491447.
    KEGGihdu:HD1582.
    PATRICi20179378. VBIHaeDuc133973_1322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96363.1 .
    RefSeqi NP_873974.1. NC_002940.2.
    WP_010945395.1. NC_002940.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EUJ X-ray 3.10 A 33-271 [» ]
    A 1263-1496 [» ]
    3EUK X-ray 4.00 A/C/F/H 33-271 [» ]
    A/C/F/H 1263-1496 [» ]
    ProteinModelPortali Q7VL96.
    SMRi Q7VL96. Positions 35-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q7VL96. 2 interactions.
    STRINGi 233412.HD1582.

    Proteomic databases

    PRIDEi Q7VL96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP96363 ; AAP96363 ; HD_1582 .
    GeneIDi 1491447.
    KEGGi hdu:HD1582.
    PATRICi 20179378. VBIHaeDuc133973_1322.

    Phylogenomic databases

    eggNOGi COG3096.
    KOi K03632.
    OMAi FALSDVM.
    OrthoDBi EOG62C98M.

    Enzyme and pathway databases

    BioCyci HDUC233412:GH5F-1423-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q7VL96.

    Family and domain databases

    HAMAPi MF_01800. MukB.
    InterProi IPR012090. MukB.
    IPR007406. MukB_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF04310. MukB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005246. MukB. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiMUKB_HAEDU
    AccessioniPrimary (citable) accession number: Q7VL96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3