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Q7VL96

- MUKB_HAEDU

UniProt

Q7VL96 - MUKB_HAEDU

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Protein

Chromosome partition protein MukB

Gene
mukB, HD_1582
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome condensation Source: UniProtKB-KW
  4. chromosome segregation Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA condensation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1423-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukB
Alternative name(s):
Structural maintenance of chromosome-related protein
Gene namesi
Name:mukB
Ordered Locus Names:HD_1582
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasmnucleoid By similarity
Note: Restricted to the nucleoid region By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleoid Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15031503Chromosome partition protein MukBUniRule annotationPRO_0000068219Add
BLAST

Proteomic databases

PRIDEiQ7VL96.

Interactioni

Subunit structurei

Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ By similarity.

Protein-protein interaction databases

IntActiQ7VL96. 2 interactions.
STRINGi233412.HD1582.

Structurei

Secondary structure

1
1503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610
Beta strandi49 – 557
Beta strandi58 – 647
Helixi71 – 8212
Turni86 – 883
Helixi109 – 1113
Beta strandi114 – 12411
Beta strandi130 – 13910
Beta strandi143 – 1453
Beta strandi151 – 1566
Beta strandi159 – 1613
Helixi163 – 1675
Beta strandi168 – 1714
Beta strandi174 – 1774
Helixi180 – 1867
Turni187 – 1893
Helixi200 – 20910
Beta strandi213 – 2153
Helixi220 – 23415
Helixi240 – 2445
Helixi246 – 2483
Turni255 – 2584
Helixi259 – 2624
Helixi1266 – 128621
Helixi1287 – 12904
Beta strandi1298 – 130710
Helixi1309 – 132012
Helixi1336 – 134611
Helixi1363 – 13653
Helixi1368 – 13703
Beta strandi1372 – 13809
Turni1381 – 13833
Beta strandi1384 – 13874
Helixi1390 – 13923
Helixi1395 – 141622
Beta strandi1418 – 14214
Beta strandi1430 – 14356
Helixi1436 – 14383
Helixi1441 – 145313
Beta strandi1457 – 14659
Beta strandi1469 – 14757
Beta strandi1478 – 14814
Beta strandi1484 – 14874
Beta strandi1490 – 14934

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10A33-271[»]
A1263-1496[»]
3EUKX-ray4.00A/C/F/H33-271[»]
A/C/F/H1263-1496[»]
ProteinModelPortaliQ7VL96.
SMRiQ7VL96. Positions 35-253.

Miscellaneous databases

EvolutionaryTraceiQ7VL96.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni696 – 813118Flexible hinge By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili370 – 495126 Reviewed predictionAdd
BLAST
Coiled coili536 – 61681 Reviewed predictionAdd
BLAST
Coiled coili662 – 69736 Reviewed predictionAdd
BLAST
Coiled coili865 – 1173309 Reviewed predictionAdd
BLAST
Coiled coili1238 – 129356 Reviewed predictionAdd
BLAST

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the SMC family. MukB subfamily.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG3096.
KOiK03632.
OMAiFALSDVM.
OrthoDBiEOG62C98M.

Family and domain databases

HAMAPiMF_01800. MukB.
InterProiIPR012090. MukB.
IPR007406. MukB_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04310. MukB. 1 hit.
[Graphical view]
PIRSFiPIRSF005246. MukB. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VL96-1 [UniParc]FASTAAdd to Basket

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MMNTNELFDQ TAVNSSQDKP LNPPFAVAQP ANIARGKFRS LTLINWNGFF     50
ARTFDFDELV TTLSGGNGAG KSTTMAGFVT ALIPDLTLLN FRNTTEAGST 100
SSSRDKGLYG KLKAGVCYAV LETVNSRAQR IITGVRLQQI AGRDKKVDIR 150
PFSLQNVPMA DSVISLFTEQ VANKARVLSL NDLKEKFEET AVTFKPYHSI 200
TDYHSFMFDL GILPKRLRSS SDRNKFYKLI EASLYGGISS VITKSLRDYL 250
LPENSGVRQA FQDMEAALRE NRMTLEAIKV TQSDRDMFKH LITEATQYVS 300
ADYMRNANER RGNVVSALAQ RRTWYDTKAK LLVEEQRLIE FSREVADINL 350
TEQSLESEYN VANDHLNLVM NALRHQEKII RYQDEVDALN EKLEQQQIAL 400
EEVSEQVEDA QAHTDEIDDR VDGLRSQIAD YQQALDAQQT RALQYQQAIT 450
ALQKAQQLCA LPHLDLDNLK DYQTEFEAQA QDITDHVFEL EQRLSISDMT 500
KTQFEKAYQL VCKVSGEIDR SQAWSEATQL LATFPDQKMQ AAQAVALRQK 550
LADLEQRLHQ QQKVQRLIAE FNQQAAKKLT DFTALENHFE QQQIKLEDLE 600
AELANVIELR SVHRQQQEQL TQQYNQLAKT APAWHTARSV LTRLEEQCAE 650
QFENSQAIMH CMQEMLRKER EATLERDELA RTEAALASQI SQLSQADGAE 700
DIRLNQLAER LGGVLLSELY DDVSLQDAPY FSALYGEARH AIVVRDLTSV 750
KAQLEKLTDC PNDLYLIEGD PTAFDDTVFS AEELYDSVIV KVSNRQWRYS 800
KFPEVPLFGR AAREKHLITL KTERDDIAEQ HAESAFNVQK YQRLHQHLSQ 850
FVGTHLNIAF QPDPEMLMQE IALERQEIEG QLNQAVENEH YLRQQADHLK 900
AELQMLNKIL PLANTLADET VMERFEECRE QLQSAEENEL FVRQFGQYLT 950
QLAPIATSLQ TDPSKFEQLE HDYQQAKSTQ RILQQKVFAL SDVMQRRLHF 1000
NYSEENQCEG SALTEQLRTD LALAQQEREQ ARQRLRQAQA QFTQYNQVLI 1050
SLRSAYDAKY QMLQELMQEI DDLGVRGDSA AEECARLRRD ELQQQLSQQR 1100
ARKGYLDKQL GIIEAEIDNL NRLLRKTERD YQTQRELVVQ AKASWCLVQK 1150
LSRNSDVEKR LNRRELAYQS AEELRSISDK ALGALRTAVA DNEYLRDSLR 1200
ASEDSRKPEN KVAFFIAVYQ HLRERIRQDI IRTDDPIDAI EQMEIELSRL 1250
INELTSREKK LAISAESVAN ILRKTIQREQ NRILQLNQGL QNIAFGQVKG 1300
VRLVVNIRDT HSILLNALSD QHEQHKDLFE SQKLSFSEAL AMLYKRVNPH 1350
IELGQRMPQT IGEELLDYRN YLDLEVETLR GADGWMRAES SALSTGEAIG 1400
TGMSILLMVV QSWEEESRRM RAKDILPCRL LFLDEAARLD AMSINTLFEL 1450
CERLDMQLLI AAPENISPEH GTTYKLVRKI LANQEYVHVV GLKGFGQQMN 1500
KST 1503
Length:1,503
Mass (Da):172,403
Last modified:October 1, 2003 - v1
Checksum:i5C847ACCAE02F0EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96363.1.
RefSeqiNP_873974.1. NC_002940.2.
WP_010945395.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96363; AAP96363; HD_1582.
GeneIDi1491447.
KEGGihdu:HD1582.
PATRICi20179378. VBIHaeDuc133973_1322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96363.1 .
RefSeqi NP_873974.1. NC_002940.2.
WP_010945395.1. NC_002940.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EUJ X-ray 3.10 A 33-271 [» ]
A 1263-1496 [» ]
3EUK X-ray 4.00 A/C/F/H 33-271 [» ]
A/C/F/H 1263-1496 [» ]
ProteinModelPortali Q7VL96.
SMRi Q7VL96. Positions 35-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7VL96. 2 interactions.
STRINGi 233412.HD1582.

Proteomic databases

PRIDEi Q7VL96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP96363 ; AAP96363 ; HD_1582 .
GeneIDi 1491447.
KEGGi hdu:HD1582.
PATRICi 20179378. VBIHaeDuc133973_1322.

Phylogenomic databases

eggNOGi COG3096.
KOi K03632.
OMAi FALSDVM.
OrthoDBi EOG62C98M.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-1423-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q7VL96.

Family and domain databases

HAMAPi MF_01800. MukB.
InterProi IPR012090. MukB.
IPR007406. MukB_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF04310. MukB. 1 hit.
[Graphical view ]
PIRSFi PIRSF005246. MukB. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiMUKB_HAEDU
AccessioniPrimary (citable) accession number: Q7VL96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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