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Q7VL96 (MUKB_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chromosome partition protein MukB
Alternative name(s):
Structural maintenance of chromosome-related protein
Gene names
Name:mukB
Ordered Locus Names:HD_1582
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus ›

Protein attributes

Sequence length1503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division By similarity. HAMAP-Rule MF_01800

Subunit structure

Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ By similarity.

Subcellular location

Cytoplasm › nucleoid By similarity. Note: Restricted to the nucleoid region By similarity.

Domain

The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer By similarity. HAMAP-Rule MF_01800

Sequence similarities

Belongs to the SMC family. MukB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15031503Chromosome partition protein MukB HAMAP-Rule MF_01800
PRO_0000068219

Regions

Nucleotide binding65 – 728ATP Potential
Region696 – 813118Flexible hinge By similarity
Coiled coil370 – 495126 Potential
Coiled coil536 – 61681 Potential
Coiled coil662 – 69736 Potential
Coiled coil865 – 1173309 Potential
Coiled coil1238 – 129356 Potential

Secondary structure

1 .................................................................................. 1503
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7VL96 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5C847ACCAE02F0EC

FASTA1,503172,403
        10         20         30         40         50         60 
MMNTNELFDQ TAVNSSQDKP LNPPFAVAQP ANIARGKFRS LTLINWNGFF ARTFDFDELV 

        70         80         90        100        110        120 
TTLSGGNGAG KSTTMAGFVT ALIPDLTLLN FRNTTEAGST SSSRDKGLYG KLKAGVCYAV 

       130        140        150        160        170        180 
LETVNSRAQR IITGVRLQQI AGRDKKVDIR PFSLQNVPMA DSVISLFTEQ VANKARVLSL 

       190        200        210        220        230        240 
NDLKEKFEET AVTFKPYHSI TDYHSFMFDL GILPKRLRSS SDRNKFYKLI EASLYGGISS 

       250        260        270        280        290        300 
VITKSLRDYL LPENSGVRQA FQDMEAALRE NRMTLEAIKV TQSDRDMFKH LITEATQYVS 

       310        320        330        340        350        360 
ADYMRNANER RGNVVSALAQ RRTWYDTKAK LLVEEQRLIE FSREVADINL TEQSLESEYN 

       370        380        390        400        410        420 
VANDHLNLVM NALRHQEKII RYQDEVDALN EKLEQQQIAL EEVSEQVEDA QAHTDEIDDR 

       430        440        450        460        470        480 
VDGLRSQIAD YQQALDAQQT RALQYQQAIT ALQKAQQLCA LPHLDLDNLK DYQTEFEAQA 

       490        500        510        520        530        540 
QDITDHVFEL EQRLSISDMT KTQFEKAYQL VCKVSGEIDR SQAWSEATQL LATFPDQKMQ 

       550        560        570        580        590        600 
AAQAVALRQK LADLEQRLHQ QQKVQRLIAE FNQQAAKKLT DFTALENHFE QQQIKLEDLE 

       610        620        630        640        650        660 
AELANVIELR SVHRQQQEQL TQQYNQLAKT APAWHTARSV LTRLEEQCAE QFENSQAIMH 

       670        680        690        700        710        720 
CMQEMLRKER EATLERDELA RTEAALASQI SQLSQADGAE DIRLNQLAER LGGVLLSELY 

       730        740        750        760        770        780 
DDVSLQDAPY FSALYGEARH AIVVRDLTSV KAQLEKLTDC PNDLYLIEGD PTAFDDTVFS 

       790        800        810        820        830        840 
AEELYDSVIV KVSNRQWRYS KFPEVPLFGR AAREKHLITL KTERDDIAEQ HAESAFNVQK 

       850        860        870        880        890        900 
YQRLHQHLSQ FVGTHLNIAF QPDPEMLMQE IALERQEIEG QLNQAVENEH YLRQQADHLK 

       910        920        930        940        950        960 
AELQMLNKIL PLANTLADET VMERFEECRE QLQSAEENEL FVRQFGQYLT QLAPIATSLQ 

       970        980        990       1000       1010       1020 
TDPSKFEQLE HDYQQAKSTQ RILQQKVFAL SDVMQRRLHF NYSEENQCEG SALTEQLRTD 

      1030       1040       1050       1060       1070       1080 
LALAQQEREQ ARQRLRQAQA QFTQYNQVLI SLRSAYDAKY QMLQELMQEI DDLGVRGDSA 

      1090       1100       1110       1120       1130       1140 
AEECARLRRD ELQQQLSQQR ARKGYLDKQL GIIEAEIDNL NRLLRKTERD YQTQRELVVQ 

      1150       1160       1170       1180       1190       1200 
AKASWCLVQK LSRNSDVEKR LNRRELAYQS AEELRSISDK ALGALRTAVA DNEYLRDSLR 

      1210       1220       1230       1240       1250       1260 
ASEDSRKPEN KVAFFIAVYQ HLRERIRQDI IRTDDPIDAI EQMEIELSRL INELTSREKK 

      1270       1280       1290       1300       1310       1320 
LAISAESVAN ILRKTIQREQ NRILQLNQGL QNIAFGQVKG VRLVVNIRDT HSILLNALSD 

      1330       1340       1350       1360       1370       1380 
QHEQHKDLFE SQKLSFSEAL AMLYKRVNPH IELGQRMPQT IGEELLDYRN YLDLEVETLR 

      1390       1400       1410       1420       1430       1440 
GADGWMRAES SALSTGEAIG TGMSILLMVV QSWEEESRRM RAKDILPCRL LFLDEAARLD 

      1450       1460       1470       1480       1490       1500 
AMSINTLFEL CERLDMQLLI AAPENISPEH GTTYKLVRKI LANQEYVHVV GLKGFGQQMN 


KST

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References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017143 Genomic DNA. Translation: AAP96363.1.
RefSeqNP_873974.1. NC_002940.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10A33-1496[»]
3EUKX-ray4.00A/C/F/H33-1496[»]
ProteinModelPortalQ7VL96.
SMRQ7VL96. Positions 35-253.
ModBaseSearch...

Protein-protein interaction databases

IntActQ7VL96. 2 interactions.
STRING233412.HD1582.

Proteomic databases

PRIDEQ7VL96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP96363; AAP96363; HD_1582.
GeneID1491447.
KEGGhdu:HD1582.
PATRIC20179378. VBIHaeDuc133973_1322.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3096.
KOK03632.
OMATENQCIN.
ProtClustDBPRK04863.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-1375-MONOMER.

Family and domain databases

HAMAPMF_01800. MukB.
InterProIPR012090. MukB.
IPR007406. MukB_N_dom.
[Graphical view]
PfamPF04310. MukB. 1 hit.
[Graphical view]
PIRSFPIRSF005246. MukB. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ7VL96.

Entry information

Entry nameMUKB_HAEDU
AccessionPrimary (citable) accession number: Q7VL96
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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