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Q7VL96

- MUKB_HAEDU

UniProt

Q7VL96 - MUKB_HAEDU

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Protein

Chromosome partition protein MukB

Gene

mukB

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome condensation Source: UniProtKB-KW
  4. chromosome segregation Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA condensation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1423-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukBUniRule annotation
Alternative name(s):
Structural maintenance of chromosome-related proteinUniRule annotation
Gene namesi
Name:mukBUniRule annotation
Ordered Locus Names:HD_1582
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasmnucleoid UniRule annotation
Note: Restricted to the nucleoid region.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleoid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15031503Chromosome partition protein MukBPRO_0000068219Add
BLAST

Proteomic databases

PRIDEiQ7VL96.

Interactioni

Subunit structurei

Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.UniRule annotation

Protein-protein interaction databases

IntActiQ7VL96. 2 interactions.
STRINGi233412.HD1582.

Structurei

Secondary structure

1
1503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610
Beta strandi49 – 557
Beta strandi58 – 647
Helixi71 – 8212
Turni86 – 883
Helixi109 – 1113
Beta strandi114 – 12411
Beta strandi130 – 13910
Beta strandi143 – 1453
Beta strandi151 – 1566
Beta strandi159 – 1613
Helixi163 – 1675
Beta strandi168 – 1714
Beta strandi174 – 1774
Helixi180 – 1867
Turni187 – 1893
Helixi200 – 20910
Beta strandi213 – 2153
Helixi220 – 23415
Helixi240 – 2445
Helixi246 – 2483
Turni255 – 2584
Helixi259 – 2624
Helixi1266 – 128621
Helixi1287 – 12904
Beta strandi1298 – 130710
Helixi1309 – 132012
Helixi1336 – 134611
Helixi1363 – 13653
Helixi1368 – 13703
Beta strandi1372 – 13809
Turni1381 – 13833
Beta strandi1384 – 13874
Helixi1390 – 13923
Helixi1395 – 141622
Beta strandi1418 – 14214
Beta strandi1430 – 14356
Helixi1436 – 14383
Helixi1441 – 145313
Beta strandi1457 – 14659
Beta strandi1469 – 14757
Beta strandi1478 – 14814
Beta strandi1484 – 14874
Beta strandi1490 – 14934

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10A33-271[»]
A1263-1496[»]
3EUKX-ray4.00A/C/F/H33-271[»]
A/C/F/H1263-1496[»]
ProteinModelPortaliQ7VL96.
SMRiQ7VL96. Positions 35-253.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7VL96.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni696 – 813118Flexible hingeUniRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili370 – 495126UniRule annotationAdd
BLAST
Coiled coili536 – 61681UniRule annotationAdd
BLAST
Coiled coili662 – 69736UniRule annotationAdd
BLAST
Coiled coili865 – 1173309UniRule annotationAdd
BLAST
Coiled coili1238 – 129356UniRule annotationAdd
BLAST

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.UniRule annotation

Sequence similaritiesi

Belongs to the SMC family. MukB subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG3096.
KOiK03632.
OMAiFALSDVM.
OrthoDBiEOG62C98M.

Family and domain databases

HAMAPiMF_01800. MukB.
InterProiIPR012090. MukB.
IPR007406. MukB_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04310. MukB. 1 hit.
[Graphical view]
PIRSFiPIRSF005246. MukB. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VL96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMNTNELFDQ TAVNSSQDKP LNPPFAVAQP ANIARGKFRS LTLINWNGFF
60 70 80 90 100
ARTFDFDELV TTLSGGNGAG KSTTMAGFVT ALIPDLTLLN FRNTTEAGST
110 120 130 140 150
SSSRDKGLYG KLKAGVCYAV LETVNSRAQR IITGVRLQQI AGRDKKVDIR
160 170 180 190 200
PFSLQNVPMA DSVISLFTEQ VANKARVLSL NDLKEKFEET AVTFKPYHSI
210 220 230 240 250
TDYHSFMFDL GILPKRLRSS SDRNKFYKLI EASLYGGISS VITKSLRDYL
260 270 280 290 300
LPENSGVRQA FQDMEAALRE NRMTLEAIKV TQSDRDMFKH LITEATQYVS
310 320 330 340 350
ADYMRNANER RGNVVSALAQ RRTWYDTKAK LLVEEQRLIE FSREVADINL
360 370 380 390 400
TEQSLESEYN VANDHLNLVM NALRHQEKII RYQDEVDALN EKLEQQQIAL
410 420 430 440 450
EEVSEQVEDA QAHTDEIDDR VDGLRSQIAD YQQALDAQQT RALQYQQAIT
460 470 480 490 500
ALQKAQQLCA LPHLDLDNLK DYQTEFEAQA QDITDHVFEL EQRLSISDMT
510 520 530 540 550
KTQFEKAYQL VCKVSGEIDR SQAWSEATQL LATFPDQKMQ AAQAVALRQK
560 570 580 590 600
LADLEQRLHQ QQKVQRLIAE FNQQAAKKLT DFTALENHFE QQQIKLEDLE
610 620 630 640 650
AELANVIELR SVHRQQQEQL TQQYNQLAKT APAWHTARSV LTRLEEQCAE
660 670 680 690 700
QFENSQAIMH CMQEMLRKER EATLERDELA RTEAALASQI SQLSQADGAE
710 720 730 740 750
DIRLNQLAER LGGVLLSELY DDVSLQDAPY FSALYGEARH AIVVRDLTSV
760 770 780 790 800
KAQLEKLTDC PNDLYLIEGD PTAFDDTVFS AEELYDSVIV KVSNRQWRYS
810 820 830 840 850
KFPEVPLFGR AAREKHLITL KTERDDIAEQ HAESAFNVQK YQRLHQHLSQ
860 870 880 890 900
FVGTHLNIAF QPDPEMLMQE IALERQEIEG QLNQAVENEH YLRQQADHLK
910 920 930 940 950
AELQMLNKIL PLANTLADET VMERFEECRE QLQSAEENEL FVRQFGQYLT
960 970 980 990 1000
QLAPIATSLQ TDPSKFEQLE HDYQQAKSTQ RILQQKVFAL SDVMQRRLHF
1010 1020 1030 1040 1050
NYSEENQCEG SALTEQLRTD LALAQQEREQ ARQRLRQAQA QFTQYNQVLI
1060 1070 1080 1090 1100
SLRSAYDAKY QMLQELMQEI DDLGVRGDSA AEECARLRRD ELQQQLSQQR
1110 1120 1130 1140 1150
ARKGYLDKQL GIIEAEIDNL NRLLRKTERD YQTQRELVVQ AKASWCLVQK
1160 1170 1180 1190 1200
LSRNSDVEKR LNRRELAYQS AEELRSISDK ALGALRTAVA DNEYLRDSLR
1210 1220 1230 1240 1250
ASEDSRKPEN KVAFFIAVYQ HLRERIRQDI IRTDDPIDAI EQMEIELSRL
1260 1270 1280 1290 1300
INELTSREKK LAISAESVAN ILRKTIQREQ NRILQLNQGL QNIAFGQVKG
1310 1320 1330 1340 1350
VRLVVNIRDT HSILLNALSD QHEQHKDLFE SQKLSFSEAL AMLYKRVNPH
1360 1370 1380 1390 1400
IELGQRMPQT IGEELLDYRN YLDLEVETLR GADGWMRAES SALSTGEAIG
1410 1420 1430 1440 1450
TGMSILLMVV QSWEEESRRM RAKDILPCRL LFLDEAARLD AMSINTLFEL
1460 1470 1480 1490 1500
CERLDMQLLI AAPENISPEH GTTYKLVRKI LANQEYVHVV GLKGFGQQMN

KST
Length:1,503
Mass (Da):172,403
Last modified:October 1, 2003 - v1
Checksum:i5C847ACCAE02F0EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96363.1.
RefSeqiNP_873974.1. NC_002940.2.
WP_010945395.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96363; AAP96363; HD_1582.
GeneIDi1491447.
KEGGihdu:HD1582.
PATRICi20179378. VBIHaeDuc133973_1322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96363.1 .
RefSeqi NP_873974.1. NC_002940.2.
WP_010945395.1. NC_002940.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EUJ X-ray 3.10 A 33-271 [» ]
A 1263-1496 [» ]
3EUK X-ray 4.00 A/C/F/H 33-271 [» ]
A/C/F/H 1263-1496 [» ]
ProteinModelPortali Q7VL96.
SMRi Q7VL96. Positions 35-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7VL96. 2 interactions.
STRINGi 233412.HD1582.

Proteomic databases

PRIDEi Q7VL96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP96363 ; AAP96363 ; HD_1582 .
GeneIDi 1491447.
KEGGi hdu:HD1582.
PATRICi 20179378. VBIHaeDuc133973_1322.

Phylogenomic databases

eggNOGi COG3096.
KOi K03632.
OMAi FALSDVM.
OrthoDBi EOG62C98M.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-1423-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q7VL96.

Family and domain databases

HAMAPi MF_01800. MukB.
InterProi IPR012090. MukB.
IPR007406. MukB_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF04310. MukB. 1 hit.
[Graphical view ]
PIRSFi PIRSF005246. MukB. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiMUKB_HAEDU
AccessioniPrimary (citable) accession number: Q7VL96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3