Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromosome partition protein MukF

Gene

mukF

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome condensation Source: UniProtKB-KW
  4. chromosome segregation Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA condensation

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukFUniRule annotation
Gene namesi
Name:mukFUniRule annotation
Ordered Locus Names:HD_1585
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasmnucleoid UniRule annotation
Note: Restricted to the nucleoid region.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleoid Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Chromosome partition protein MukFPRO_0000211605Add
BLAST

Interactioni

Subunit structurei

Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.UniRule annotation

Protein-protein interaction databases

IntActiQ7VL94. 2 interactions.
STRINGi233412.HD1585.

Structurei

Secondary structure

1
443
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi357 – 37216Combined sources
Helixi379 – 3868Combined sources
Turni387 – 3893Combined sources
Helixi392 – 3943Combined sources
Helixi395 – 40814Combined sources
Helixi414 – 4174Combined sources
Beta strandi424 – 4263Combined sources
Turni427 – 4304Combined sources
Beta strandi431 – 4344Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10B292-443[»]
3EUKX-ray4.00E/J292-443[»]
ProteinModelPortaliQ7VL94.
SMRiQ7VL94. Positions 9-282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7VL94.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 23729Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the MukF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3006.
KOiK03633.
OMAiMALEYES.
OrthoDBiEOG6SV55C.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01803. MukF.
InterProiIPR005582. Chromosome_partition_MukF.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03882. KicB. 1 hit.
[Graphical view]
PIRSFiPIRSF018282. MukF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VL94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNELAQTIP ELISWTKERE FSLSLPSDRL AFLLVISIYN NEQTDGELLE
60 70 80 90 100
SDLIDLFRYV SNVFEQSEAS LLQRANNAIN DLVKQRFLNR FSSEFTEGLA
110 120 130 140 150
IYRVTPLGVG VSDYYVRQRE FSSLRLSIQL SIVADEIQRA SVAAEQGGDE
160 170 180 190 200
RYWRNNVFAP LKFSVAEIFD SIDLSQRMMD ENQHQIREQI AGLLSQNWHE
210 220 230 240 250
AIINCQQLLD ETSINLRELQ DTLNAAGDKL QSQLLRIQSC LISRDDLAFV
260 270 280 290 300
DQLIVNLQNK LDRIMSWGQQ AIDLWIGYDK HVHKFIRTAI DMDKNRVFGQ
310 320 330 340 350
RLRQSIQNYF SSPWLLYTAK AEALLDLRDD EAMLNEMEAV GELPMALEYE
360 370 380 390 400
SLTDVQTQIV TAIQAELAHF RDTAQPINLG AVLREQLARY PQSRHFDVAR
410 420 430 440
IIVDQAVKLG MASQDHQAVY PVWQPIDDFS AAVQAHLIDQ YDK
Length:443
Mass (Da):50,905
Last modified:October 1, 2003 - v1
Checksum:iEDDED14614BAE956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017143 Genomic DNA. Translation: AAP96365.1.
RefSeqiNP_873976.1. NC_002940.2.
WP_010945397.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96365; AAP96365; HD_1585.
GeneIDi1491449.
KEGGihdu:HD1585.
PATRICi20179382. VBIHaeDuc133973_1324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017143 Genomic DNA. Translation: AAP96365.1.
RefSeqiNP_873976.1. NC_002940.2.
WP_010945397.1. NC_002940.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10B292-443[»]
3EUKX-ray4.00E/J292-443[»]
ProteinModelPortaliQ7VL94.
SMRiQ7VL94. Positions 9-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7VL94. 2 interactions.
STRINGi233412.HD1585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP96365; AAP96365; HD_1585.
GeneIDi1491449.
KEGGihdu:HD1585.
PATRICi20179382. VBIHaeDuc133973_1324.

Phylogenomic databases

eggNOGiCOG3006.
KOiK03633.
OMAiMALEYES.
OrthoDBiEOG6SV55C.

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1425-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ7VL94.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01803. MukF.
InterProiIPR005582. Chromosome_partition_MukF.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03882. KicB. 1 hit.
[Graphical view]
PIRSFiPIRSF018282. MukF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiMUKF_HAEDU
AccessioniPrimary (citable) accession number: Q7VL94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.