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Q7VL94 (MUKF_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosome partition protein MukF
Gene names
Name:mukF
Ordered Locus Names:HD_1585
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity By similarity. HAMAP-Rule MF_01803

Subunit structure

Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB By similarity.

Subcellular location

Cytoplasmnucleoid By similarity. Note: Restricted to the nucleoid region By similarity. HAMAP-Rule MF_01803

Sequence similarities

Belongs to the MukF family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Chromosome partition
DNA condensation
   Cellular componentCytoplasm
   LigandCalcium
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

chromosome condensation

Inferred from electronic annotation. Source: UniProtKB-KW

chromosome segregation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoid

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Chromosome partition protein MukF HAMAP-Rule MF_01803
PRO_0000211605

Regions

Region209 – 23729Leucine-zipper HAMAP-Rule MF_01803

Secondary structure

............... 443
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7VL94 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EDDED14614BAE956

FASTA44350,905
        10         20         30         40         50         60 
MQNELAQTIP ELISWTKERE FSLSLPSDRL AFLLVISIYN NEQTDGELLE SDLIDLFRYV 

        70         80         90        100        110        120 
SNVFEQSEAS LLQRANNAIN DLVKQRFLNR FSSEFTEGLA IYRVTPLGVG VSDYYVRQRE 

       130        140        150        160        170        180 
FSSLRLSIQL SIVADEIQRA SVAAEQGGDE RYWRNNVFAP LKFSVAEIFD SIDLSQRMMD 

       190        200        210        220        230        240 
ENQHQIREQI AGLLSQNWHE AIINCQQLLD ETSINLRELQ DTLNAAGDKL QSQLLRIQSC 

       250        260        270        280        290        300 
LISRDDLAFV DQLIVNLQNK LDRIMSWGQQ AIDLWIGYDK HVHKFIRTAI DMDKNRVFGQ 

       310        320        330        340        350        360 
RLRQSIQNYF SSPWLLYTAK AEALLDLRDD EAMLNEMEAV GELPMALEYE SLTDVQTQIV 

       370        380        390        400        410        420 
TAIQAELAHF RDTAQPINLG AVLREQLARY PQSRHFDVAR IIVDQAVKLG MASQDHQAVY 

       430        440 
PVWQPIDDFS AAVQAHLIDQ YDK 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP96365.1.
RefSeqNP_873976.1. NC_002940.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10B292-443[»]
3EUKX-ray4.00E/J292-443[»]
ProteinModelPortalQ7VL94.
SMRQ7VL94. Positions 9-282.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ7VL94. 2 interactions.
STRING233412.HD1585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP96365; AAP96365; HD_1585.
GeneID1491449.
KEGGhdu:HD1585.
PATRIC20179382. VBIHaeDuc133973_1324.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3006.
KOK03633.
OMANRFSSEF.
OrthoDBEOG6SV55C.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-1425-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_01803. MukF.
InterProIPR005582. Chromosome_partition_MukF.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF03882. KicB. 1 hit.
[Graphical view]
PIRSFPIRSF018282. MukF. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ7VL94.

Entry information

Entry nameMUKF_HAEDU
AccessionPrimary (citable) accession number: Q7VL94
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references