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Q7VL94

- MUKF_HAEDU

UniProt

Q7VL94 - MUKF_HAEDU

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Protein
Chromosome partition protein MukF
Gene
mukF, HD_1585
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity By similarity.UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-HAMAP
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. chromosome condensation Source: UniProtKB-KW
  5. chromosome segregation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA condensation

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukF
Gene namesi
Name:mukF
Ordered Locus Names:HD_1585
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasmnucleoid By similarity
Note: Restricted to the nucleoid region By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleoid Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Chromosome partition protein MukFUniRule annotation
PRO_0000211605Add
BLAST

Interactioni

Subunit structurei

Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB By similarity.

Protein-protein interaction databases

IntActiQ7VL94. 2 interactions.
STRINGi233412.HD1585.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi357 – 37216
Helixi379 – 3868
Turni387 – 3893
Helixi392 – 3943
Helixi395 – 40814
Helixi414 – 4174
Beta strandi424 – 4263
Turni427 – 4304
Beta strandi431 – 4344

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10B292-443[»]
3EUKX-ray4.00E/J292-443[»]
ProteinModelPortaliQ7VL94.
SMRiQ7VL94. Positions 9-282.

Miscellaneous databases

EvolutionaryTraceiQ7VL94.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 23729Leucine-zipperUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the MukF family.

Phylogenomic databases

eggNOGiCOG3006.
KOiK03633.
OMAiNRFSSEF.
OrthoDBiEOG6SV55C.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01803. MukF.
InterProiIPR005582. Chromosome_partition_MukF.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03882. KicB. 1 hit.
[Graphical view]
PIRSFiPIRSF018282. MukF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VL94-1 [UniParc]FASTAAdd to Basket

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MQNELAQTIP ELISWTKERE FSLSLPSDRL AFLLVISIYN NEQTDGELLE    50
SDLIDLFRYV SNVFEQSEAS LLQRANNAIN DLVKQRFLNR FSSEFTEGLA 100
IYRVTPLGVG VSDYYVRQRE FSSLRLSIQL SIVADEIQRA SVAAEQGGDE 150
RYWRNNVFAP LKFSVAEIFD SIDLSQRMMD ENQHQIREQI AGLLSQNWHE 200
AIINCQQLLD ETSINLRELQ DTLNAAGDKL QSQLLRIQSC LISRDDLAFV 250
DQLIVNLQNK LDRIMSWGQQ AIDLWIGYDK HVHKFIRTAI DMDKNRVFGQ 300
RLRQSIQNYF SSPWLLYTAK AEALLDLRDD EAMLNEMEAV GELPMALEYE 350
SLTDVQTQIV TAIQAELAHF RDTAQPINLG AVLREQLARY PQSRHFDVAR 400
IIVDQAVKLG MASQDHQAVY PVWQPIDDFS AAVQAHLIDQ YDK 443
Length:443
Mass (Da):50,905
Last modified:October 1, 2003 - v1
Checksum:iEDDED14614BAE956
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96365.1.
RefSeqiNP_873976.1. NC_002940.2.
WP_010945397.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96365; AAP96365; HD_1585.
GeneIDi1491449.
KEGGihdu:HD1585.
PATRICi20179382. VBIHaeDuc133973_1324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96365.1 .
RefSeqi NP_873976.1. NC_002940.2.
WP_010945397.1. NC_002940.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EUJ X-ray 3.10 B 292-443 [» ]
3EUK X-ray 4.00 E/J 292-443 [» ]
ProteinModelPortali Q7VL94.
SMRi Q7VL94. Positions 9-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7VL94. 2 interactions.
STRINGi 233412.HD1585.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP96365 ; AAP96365 ; HD_1585 .
GeneIDi 1491449.
KEGGi hdu:HD1585.
PATRICi 20179382. VBIHaeDuc133973_1324.

Phylogenomic databases

eggNOGi COG3006.
KOi K03633.
OMAi NRFSSEF.
OrthoDBi EOG6SV55C.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-1425-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q7VL94.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_01803. MukF.
InterProi IPR005582. Chromosome_partition_MukF.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF03882. KicB. 1 hit.
[Graphical view ]
PIRSFi PIRSF018282. MukF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiMUKF_HAEDU
AccessioniPrimary (citable) accession number: Q7VL94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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