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Protein

Chromosome partition protein MukF

Gene

mukF

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, DNA condensation
LigandCalcium

Enzyme and pathway databases

BioCyciHDUC233412:G1G0H-1298-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein MukFUniRule annotation
Gene namesi
Name:mukFUniRule annotation
Ordered Locus Names:HD_1585
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000001022 Componenti: Chromosome

Subcellular locationi

  • nucleoid UniRule annotation
  • Note: Restricted to the nucleoid region.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002116051 – 443Chromosome partition protein MukFAdd BLAST443

Interactioni

Subunit structurei

Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.UniRule annotation

Protein-protein interaction databases

IntActiQ7VL94, 2 interactors
STRINGi233412.HD1585

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi357 – 372Combined sources16
Helixi379 – 386Combined sources8
Turni387 – 389Combined sources3
Helixi392 – 394Combined sources3
Helixi395 – 408Combined sources14
Helixi414 – 417Combined sources4
Beta strandi424 – 426Combined sources3
Turni427 – 430Combined sources4
Beta strandi431 – 434Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EUJX-ray3.10B292-443[»]
3EUKX-ray4.00E/J292-443[»]
ProteinModelPortaliQ7VL94
SMRiQ7VL94
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7VL94

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 237Leucine-zipperAdd BLAST29

Sequence similaritiesi

Belongs to the MukF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105GHU Bacteria
COG3006 LUCA
KOiK03633
OMAiLLRIQDC
OrthoDBiPOG091H05JX

Family and domain databases

CDDicd16337 MukF_C, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.225.40, 1 hit
1.20.58.590, 1 hit
HAMAPiMF_01803 MukF, 1 hit
InterProiView protein in InterPro
IPR005582 Chromosome_partition_MukF
IPR033441 MukF_C
IPR038198 MukF_C_sf
IPR033440 MukF_M
IPR036141 MukF_M_sp
IPR033439 MukF_WHTH
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF03882 KicB, 1 hit
PF17193 MukF_C, 1 hit
PF17192 MukF_M, 1 hit
PIRSFiPIRSF018282 MukF, 1 hit
SUPFAMiSSF140570 SSF140570, 1 hit
SSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

Q7VL94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNELAQTIP ELISWTKERE FSLSLPSDRL AFLLVISIYN NEQTDGELLE
60 70 80 90 100
SDLIDLFRYV SNVFEQSEAS LLQRANNAIN DLVKQRFLNR FSSEFTEGLA
110 120 130 140 150
IYRVTPLGVG VSDYYVRQRE FSSLRLSIQL SIVADEIQRA SVAAEQGGDE
160 170 180 190 200
RYWRNNVFAP LKFSVAEIFD SIDLSQRMMD ENQHQIREQI AGLLSQNWHE
210 220 230 240 250
AIINCQQLLD ETSINLRELQ DTLNAAGDKL QSQLLRIQSC LISRDDLAFV
260 270 280 290 300
DQLIVNLQNK LDRIMSWGQQ AIDLWIGYDK HVHKFIRTAI DMDKNRVFGQ
310 320 330 340 350
RLRQSIQNYF SSPWLLYTAK AEALLDLRDD EAMLNEMEAV GELPMALEYE
360 370 380 390 400
SLTDVQTQIV TAIQAELAHF RDTAQPINLG AVLREQLARY PQSRHFDVAR
410 420 430 440
IIVDQAVKLG MASQDHQAVY PVWQPIDDFS AAVQAHLIDQ YDK
Length:443
Mass (Da):50,905
Last modified:October 1, 2003 - v1
Checksum:iEDDED14614BAE956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017143 Genomic DNA Translation: AAP96365.1
RefSeqiWP_010945397.1, NC_002940.2

Genome annotation databases

EnsemblBacteriaiAAP96365; AAP96365; HD_1585
GeneIDi24943842
KEGGihdu:HD_1585

Similar proteinsi

Entry informationi

Entry nameiMUKF_HAEDU
AccessioniPrimary (citable) accession number: Q7VL94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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