Reviewed, UniProtKB/Swiss-Prot Q7VL12 (BIOD2_HAEDU)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase 2
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase 2
    DTB synthetase 2
      Short name=DTBS 2

Gene names

Name:	bioD2
Ordered Locus Names:	HD_1680

Organism

Haemophilus ducreyi [Complete proteome] [HAMAP]

Taxonomic identifier

730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity. HAMAP MF_00336
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP cobalamin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP cobyrinic acid a,c-diamide synthase activity Inferred from electronic annotation. Source: InterPro dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Dethiobiotin synthetase 2 HAMAP MF_00336		PRO_0000187968
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VL12-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 92DA228C4337A54C	FASTA	211	23,679
	10 20 30 40 50 60 MGKIIFVSGI DTDIGKTIAT GFYAKRLMQQ GFSVITQKMI QTGCQHISAD IIKHRQLQGI 70 80 90 100 110 120 ELTAEDLNGI TCPYLFRYPC SPHLAAEMEN NPILPSKIAQ ASALLAQKYD YVLLEGAGGL 130 140 150 160 170 180 AVPYNSQQTT LDYIVEQQLP LILVTSAKLG SINHTLLSLI VCQQHKIEME AVIYNTYPLE 190 200 210 DEKIAKSTQL YLQQYIKQHF PNTEFLVMDR Q

References

[1]

"The complete genome sequence of Haemophilus ducreyi." Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017143 Genomic DNA. Translation: AAP96447.1.
RefSeq	NP_874058.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1491539.
GenomeReviews	Gene locus HD_1680 in contig AE017143_GR.
KEGG	hdu:HD1680.
NMPDR	fig|233412.1.peg.1423.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG650065.
OMA	LNNYNHE.
Enzyme and pathway databases
BioCyc	HDUC233412:HD_1680-MONOMER.
BRENDA	6.3.3.3. 265031.
Family and domain databases
HAMAP	MF_00336. BioD. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD2_HAEDU

Accession

Primary (citable) accession number: Q7VL12

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2003
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)