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Q7VKQ4

- APT_HAEDU

UniProt

Q7VKQ4 - APT_HAEDU

Protein

Adenine phosphoribosyltransferase

Gene

apt

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. adenine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. adenine salvage Source: InterPro
    2. AMP salvage Source: UniProtKB-UniPathway
    3. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1641-MONOMER.
    UniPathwayiUPA00588; UER00646.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.7UniRule annotation)
    Short name:
    APRTUniRule annotation
    Gene namesi
    Name:aptUniRule annotation
    Ordered Locus Names:HD_1818
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Adenine phosphoribosyltransferasePRO_0000149390Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi233412.HD1818.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VKQ4.
    SMRiQ7VKQ4. Positions 3-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0503.
    KOiK00759.
    OMAiAGIMFRD.
    OrthoDBiEOG6T4S55.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_00004. Aden_phosphoribosyltr.
    InterProiIPR005764. Ade_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01090. apt. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7VKQ4-1 [UniParc]FASTAAdd to Basket

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    MNQLDLIKSS IKSIPNYPKV GIIFRDITSL LENPTAFKAS IDAIVAEFKN    50
    KGITKVVGTE SRGFIFGAPV ALALGLPFVL VRKPHKLPRA VISQSYALEY 100
    GEDTLEMHLD SINQDDNVLV VDDLLATGGT IDATAKLIRQ LGGQVKNAAF 150
    VIGLPDLGGK ARLEQIGIKS FTLVEFDGH 179
    Length:179
    Mass (Da):19,315
    Last modified:October 1, 2003 - v1
    Checksum:i13A1DAFDC13560DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96568.1.
    RefSeqiNP_874179.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP96568; AAP96568; HD_1818.
    GeneIDi1491665.
    KEGGihdu:HD1818.
    PATRICi20179806. VBIHaeDuc133973_1530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96568.1 .
    RefSeqi NP_874179.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VKQ4.
    SMRi Q7VKQ4. Positions 3-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD1818.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP96568 ; AAP96568 ; HD_1818 .
    GeneIDi 1491665.
    KEGGi hdu:HD1818.
    PATRICi 20179806. VBIHaeDuc133973_1530.

    Phylogenomic databases

    eggNOGi COG0503.
    KOi K00759.
    OMAi AGIMFRD.
    OrthoDBi EOG6T4S55.

    Enzyme and pathway databases

    UniPathwayi UPA00588 ; UER00646 .
    BioCyci HDUC233412:GH5F-1641-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_00004. Aden_phosphoribosyltr.
    InterProi IPR005764. Ade_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01090. apt. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiAPT_HAEDU
    AccessioniPrimary (citable) accession number: Q7VKQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3