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Q7VKQ4 (APT_HAEDU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenine phosphoribosyltransferase

Short name=APRT
EC=2.4.2.7
Gene names
Name:apt
Ordered Locus Names:HD_1818
OrganismHaemophilus ducreyi (strain 35000HP / ATCC 700724) [Complete proteome] [HAMAP]
Taxonomic identifier233412 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004

Catalytic activity

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00004

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00004.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processAMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

adenine salvage

Inferred from electronic annotation. Source: InterPro

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Adenine phosphoribosyltransferase HAMAP-Rule MF_00004
PRO_0000149390

Sequences

Sequence LengthMass (Da)Tools
Q7VKQ4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 13A1DAFDC13560DF

FASTA17919,315
        10         20         30         40         50         60 
MNQLDLIKSS IKSIPNYPKV GIIFRDITSL LENPTAFKAS IDAIVAEFKN KGITKVVGTE 

        70         80         90        100        110        120 
SRGFIFGAPV ALALGLPFVL VRKPHKLPRA VISQSYALEY GEDTLEMHLD SINQDDNVLV 

       130        140        150        160        170 
VDDLLATGGT IDATAKLIRQ LGGQVKNAAF VIGLPDLGGK ARLEQIGIKS FTLVEFDGH 

« Hide

References

[1]"The complete genome sequence of Haemophilus ducreyi."
Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 35000HP / ATCC 700724.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017143 Genomic DNA. Translation: AAP96568.1.
RefSeqNP_874179.1. NC_002940.2.

3D structure databases

ProteinModelPortalQ7VKQ4.
SMRQ7VKQ4. Positions 3-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233412.HD1818.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAP96568; AAP96568; HD_1818.
GeneID1491665.
KEGGhdu:HD1818.
PATRIC20179806. VBIHaeDuc133973_1530.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
KOK00759.
OMAAGIMFRD.
OrthoDBEOG6T4S55.

Enzyme and pathway databases

BioCycHDUC233412:GH5F-1641-MONOMER.
UniPathwayUPA00588; UER00646.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_00004. Aden_phosphoribosyltr.
InterProIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01090. apt. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPT_HAEDU
AccessionPrimary (citable) accession number: Q7VKQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways