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Q7VKP3

- KGUA_HAEDU

UniProt

Q7VKP3 - KGUA_HAEDU

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Protein
Guanylate kinase
Gene
gmk, HD_1830
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHDUC233412:GH5F-1652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:HD_1830
OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
Taxonomic identifieri233412 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000001022: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Guanylate kinaseUniRule annotation
PRO_0000170544Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233412.HD1830.

Structurei

3D structure databases

ProteinModelPortaliQ7VKP3.
SMRiQ7VKP3. Positions 3-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 183181Guanylate kinase-like
Add
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
KOiK00942.
OMAiMSHYNEY.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7VKP3-1 [UniParc]FASTAAdd to Basket

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MLGNLYILSA PSGAGKSSLI NALLADLPRT EVQLSISHTT RQPRVGETHG    50
IHYYFTEHHE FESLIEQGHF LEWARVFDHY YGTSLPMIER SLAQGIDVFL 100
DIDWQGARQI REKVPNVKTI FILPPSRAEL EKRLVGRGQD SLETIAKRME 150
QAVSEMTHYN EFDYVIINDQ FKTALTELKS ILTAERLKQS AQAIRQQALI 200
AELLAE 206
Length:206
Mass (Da):23,478
Last modified:October 1, 2003 - v1
Checksum:i1D2798C0C082CB9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96579.1.
RefSeqiNP_874190.1. NC_002940.2.

Genome annotation databases

EnsemblBacteriaiAAP96579; AAP96579; HD_1830.
GeneIDi1491676.
KEGGihdu:HD1830.
PATRICi20179826. VBIHaeDuc133973_1540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017143 Genomic DNA. Translation: AAP96579.1 .
RefSeqi NP_874190.1. NC_002940.2.

3D structure databases

ProteinModelPortali Q7VKP3.
SMRi Q7VKP3. Positions 3-206.
ModBasei Search...

Protein-protein interaction databases

STRINGi 233412.HD1830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP96579 ; AAP96579 ; HD_1830 .
GeneIDi 1491676.
KEGGi hdu:HD1830.
PATRICi 20179826. VBIHaeDuc133973_1540.

Phylogenomic databases

eggNOGi COG0194.
KOi K00942.
OMAi MSHYNEY.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci HDUC233412:GH5F-1652-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Haemophilus ducreyi."
    Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 35000HP / ATCC 700724.

Entry informationi

Entry nameiKGUA_HAEDU
AccessioniPrimary (citable) accession number: Q7VKP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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