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Q7VKK4

- GLMS_HAEDU

UniProt

Q7VKK4 - GLMS_HAEDU

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei605 – 6051For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciHDUC233412:GH5F-1707-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:HD_1894
    OrganismiHaemophilus ducreyi (strain 35000HP / ATCC 700724)
    Taxonomic identifieri233412 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000001022: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 610609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135338Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi233412.HD1894.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7VKK4.
    SMRiQ7VKK4. Positions 2-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini286 – 426141SIS 1UniRule annotationAdd
    BLAST
    Domaini459 – 600142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7VKK4-1 [UniParc]FASTAAdd to Basket

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    MCGIVGAVAQ RDVADILVDG LHRLEYRGYD SAGVAVLNEQ HHMQIIRRVG    50
    KVKALEEAVI GEKVFGGTGI AHTRWATHGE PSEINAHPHR SGKIAVVHNG 100
    IIENYEALKV VLQQRGYIFA SHTDTEVIAH LVEWELRTAH SLLEAVQKAV 150
    VQLRGAYGTV VMNQDDPTRL VVARSGSPLV IGYGIGENFI ASDPLALLSV 200
    THRFAYLEEG DVAEITRHAV AIYNQAGEAV TREIHQGNFE QDAADKGVYR 250
    HYMQKEIFEQ PIAIMNTLAG RIKDGQVNIE AIAPNAADIL AKVEHIQIVA 300
    CGTSYNAGMV ARYWFEEIAN ISCNVEIASE FRYRKFVVQP NSLLITLSQS 350
    GETADTLAAL RLAKQSGYMA AMTICNVASS SLVRESDFAF MTKAGIEIGV 400
    ASTKAFTTQL TCLLLLNVAI GRLKGRLSVA QEQQIVQSLQ KLPSQIESAL 450
    VFDKAIEKLS EDFADKQHTL FLGRGEFYPI AMESALKLKE ISYIHAEAYA 500
    AGELKHGPLA LIDSEMPVVV VAPENDLLEK VKSNIEEVRA RGGQLYVFAD 550
    HEAGFEQTVD FKTIVLPRVD AVTAPIFYTV PLQLLSYHIA LIKGTDVDQP 600
    RNLAKAVTVE 610
    Length:610
    Mass (Da):66,860
    Last modified:January 23, 2007 - v3
    Checksum:iFEDC6FEE27AE71A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96623.1.
    RefSeqiNP_874234.1. NC_002940.2.
    WP_010945651.1. NC_002940.2.

    Genome annotation databases

    EnsemblBacteriaiAAP96623; AAP96623; HD_1894.
    GeneIDi1491731.
    KEGGihdu:HD1894.
    PATRICi20179936. VBIHaeDuc133973_1588.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017143 Genomic DNA. Translation: AAP96623.1 .
    RefSeqi NP_874234.1. NC_002940.2.
    WP_010945651.1. NC_002940.2.

    3D structure databases

    ProteinModelPortali Q7VKK4.
    SMRi Q7VKK4. Positions 2-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233412.HD1894.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP96623 ; AAP96623 ; HD_1894 .
    GeneIDi 1491731.
    KEGGi hdu:HD1894.
    PATRICi 20179936. VBIHaeDuc133973_1588.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci HDUC233412:GH5F-1707-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Haemophilus ducreyi."
      Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L., Nguyen D., Wang J., Forst C., Hood L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 35000HP / ATCC 700724.

    Entry informationi

    Entry nameiGLMS_HAEDU
    AccessioniPrimary (citable) accession number: Q7VKK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3