Q7VK57 (PANC_HELHP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate synthetase
Short name=PS
EC=6.3.2.1

Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	HH_0035

Organism

Helicobacter hepaticus (strain ATCC 51449 / 3B1) [Complete proteome] [HAMAP]

Taxonomic identifier

235279 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP MF_00158
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158
Subunit structure	Homodimer By similarity. HAMAP MF_00158
Subcellular location	Cytoplasm Potential HAMAP MF_00158.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP MF_00158
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Pantothenate synthetase HAMAP MF_00158		PRO_0000305464
Regions
	Nucleotide binding	29 – 36	8	ATP By similarity
	Nucleotide binding	146 – 149	4	ATP By similarity
	Nucleotide binding	183 – 186	4	ATP By similarity
Sites
	Active site	36	1	Proton donor By similarity
	Binding site	60	1	Beta-alanine By similarity
	Binding site	60	1	Pantoate By similarity
	Binding site	152	1	Pantoate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7VK57 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 4A24E8C121E6A1ED	FASTA	277	31,227
	10 20 30 40 50 60 MRVIQSICEM RHYRAGIAND KTIGFVATMG ALHQGHLSLM KASLAENDYT IVSIFVNPTQ 70 80 90 100 110 120 FGANEDFGAY PRTLEADIAL CERVGVSAIF APSIDDMYED DEVGFSAPKK MGYILEGFDR 130 140 150 160 170 180 PTHFAGVLQI VLKLFCLIKP HRAYFGQKDA QQVLILQKMV RDLFLDIHIV PCPIQRDSDG 190 200 210 220 230 240 LALSSRNIYL SASERQKALC IPRTIELVKK RILQGEREVA TLREIALQSL QSEDITLFYA 250 260 270 QFCNHKLEPI THIVENKSIF LIAAKVGQTR LLDNLWI

References

[1]

"The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus." Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M., Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R., Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B. , Shen Z., Weber J., Frosch M., Fox J.G. Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003) [PubMed: 12810954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51449 / 3B1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017125 Genomic DNA. Translation: AAP76632.1.
RefSeq	NP_859566.1. NC_004917.1.
3D structure databases
HSSP	HSSP built from PDB template 2A84 based on UniProtKB P0A5R0.
ProteinModelPortal	Q7VK57.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1493791.
GenomeReviews	Gene locus HH_0035 in contig AE017125_GR.
KEGG	hhe:HH0035.
NMPDR	fig|235279.1.peg.35.
PATRIC	20587488. VBIHelHep90276_0036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG428839.
OMA	EMDGLAM.
ProtClustDB	PRK00380.
Enzyme and pathway databases
BioCyc	HHEP235279:HH_0035-MONOMER.
Family and domain databases
HAMAP	MF_00158. PanC. [Tree]
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01918.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. PanC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_HELHP

Accession

Primary (citable) accession number: Q7VK57

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program