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Q7VJT5

- NAPA_HELHP

UniProt

Q7VJT5 - NAPA_HELHP

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Protein

Periplasmic nitrate reductase

Gene
napA, HH_0158
Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism By similarity.UniRule annotation

Catalytic activityi

Nitrite + acceptor = nitrate + reduced acceptor.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotation
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Iron-sulfur (4Fe-4S) By similarity
Metal bindingi59 – 591Iron-sulfur (4Fe-4S) By similarity
Metal bindingi63 – 631Iron-sulfur (4Fe-4S) By similarity
Metal bindingi96 – 961Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. electron carrier activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. molybdenum ion binding Source: InterPro
  5. nitrate reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
  2. nitrate assimilation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Nitrate assimilation, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-162-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic nitrate reductase (EC:1.7.99.4)
Gene namesi
Name:napA
Ordered Locus Names:HH_0158
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

Subcellular locationi

Periplasm By similarity UniRule annotation

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Tat-type signal Reviewed predictionAdd
BLAST
Chaini43 – 937895Periplasmic nitrate reductaseUniRule annotationPRO_0000045989Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.UniRule annotation

Interactioni

Subunit structurei

Interacts with NapB By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi235279.HH0158.

Structurei

3D structure databases

ProteinModelPortaliQ7VJT5.
SMRiQ7VJT5. Positions 49-936.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 110624Fe-4S Mo/W bis-MGD-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0243.
KOiK02567.
OMAiHPKTRVA.
OrthoDBiEOG6CVV7G.

Family and domain databases

HAMAPiMF_01630. Nitrate_reduct.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10518. TAT_signal. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01706. NAPA. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7VJT5-1 [UniParc]FASTAAdd to Basket

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MTSKIQGKKP TLSRRDFIKS AAAASAAASV GLSIPSVMSA EAQNAQKLWK    50
WDKSVCRFCG TGCGIMVATQ KDNTGQAKIV AIKGDPEAPV NRGLNCIKGY 100
FCAKIMYGAD RLTTPLLRVN SNGEFDKKGK FAPVSWKRAF DEMEKQFKKA 150
YNELGPTGIA VFGSGQYTIQ EGYAAVKLVK GGFRSNNIDP NARHCMASAV 200
VGFMETFGID EPAGCYDDIE LTDTIVTWGA NMAEMHPVLW SRVTDRKLSS 250
SNVKVINLST YTNRTSDLAD IEIIFKPHTD LAIWNFLARE IINRNAVDEA 300
FVKENCVFST GFVNIGYGMR NNPQHPKFKP EERDIVAKEV SKIVSNDEGI 350
TLQYLGIKAG EEMKMDKAGA AGNHWGISFE DFKKGLEPYT LDFVANLAKG 400
NPDESIESFK QKLQSLADYY IDKNRKIVSF WTMGMNQHQR GTWVNEQSYM 450
VHMLLGKQAK PGSGAFSLTG QPSACGTARE VGTFSHRLPA DMVVANPKHR 500
EITEKIWHLP SGTLNSKIGA PYLKIMRDLE DGNIKWAWVQ VNNPWQNTAN 550
ANHWIAAARE QDNFIVVSEC YPGISAKVAD LILPTAMIYE KWGAYGNAER 600
RTQHWKQQVV APGEAMPDIW QMAEFAKRFK LSEVWDKGYE ALDIKPVLES 650
AKAMGYTEED TLFDVLFANK NAKNFSAQDA LLKNEFNTEV LGDSRNVEDG 700
NGEAFKGYGF FIQKYLWEEY RQFGLGHAHD LADFDTYHRV RGLRWPVVNG 750
KETQWRFNAK YDFYAQKLGN GKAFAFYGNK GKDMPAGSLN APSEEKVSID 800
NKAKIFLRPY MDPCEMPDKE YPMWLCTGRV LEHWHSGTMT MRVPELYRAV 850
PEALCYMHPD DANAQNLEQN QVVWVESRRG KVKAKLDLRG RNRPPKGLIY 900
VPWFDENVFI NKVCLDATCP ISKQTDFKKC AVKVYKA 937
Length:937
Mass (Da):105,424
Last modified:October 1, 2003 - v1
Checksum:iD89063CE3968E830
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP76755.1.
RefSeqiNP_859689.1. NC_004917.1.
WP_011115001.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP76755; AAP76755; HH_0158.
GeneIDi1493213.
KEGGihhe:HH0158.
PATRICi20587728. VBIHelHep90276_0155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017125 Genomic DNA. Translation: AAP76755.1 .
RefSeqi NP_859689.1. NC_004917.1.
WP_011115001.1. NC_004917.1.

3D structure databases

ProteinModelPortali Q7VJT5.
SMRi Q7VJT5. Positions 49-936.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235279.HH0158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP76755 ; AAP76755 ; HH_0158 .
GeneIDi 1493213.
KEGGi hhe:HH0158.
PATRICi 20587728. VBIHelHep90276_0155.

Phylogenomic databases

eggNOGi COG0243.
KOi K02567.
OMAi HPKTRVA.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci HHEP235279:GHUA-162-MONOMER.

Family and domain databases

HAMAPi MF_01630. Nitrate_reduct.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
IPR019546. TAT_signal_bac_arc.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10518. TAT_signal. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR01706. NAPA. 1 hit.
TIGR01409. TAT_signal_seq. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1.

Entry informationi

Entry nameiNAPA_HELHP
AccessioniPrimary (citable) accession number: Q7VJT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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