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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.SAAS annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseSAAS annotationImported, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesisSAAS annotation

Enzyme and pathway databases

BioCyciHHEP235279:GHUA-172-MONOMER.
UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseSAAS annotation (EC:2.7.7.38SAAS annotation)
Gene namesi
Name:kdsBImported
Ordered Locus Names:HH_0168Imported
OrganismiHelicobacter hepaticus (strain ATCC 51449 / 3B1)Imported
Taxonomic identifieri235279 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000002495: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi235279.HH0168.

Structurei

3D structure databases

ProteinModelPortaliQ7VJS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK00979.
OMAiNSGTERC.
OrthoDBiEOG6KT2SK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7VJS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIIPARLES TRFPKKVLCD IGGLPMVVRT ALNAQQVDSV VVACDDEQIA
60 70 80 90 100
SVCKTHKIPC VMTAKSHSSG TDRCAEASKK LGLSDNEIIL NIQADEPFLE
110 120 130 140 150
TSVIRTLQDL MKKHTPFMGS LAKIICESDI ADSNLVKVVL NAHNEAIYFS
160 170 180 190 200
RSPIPFCRDG QSEELKTYPY LGHLGLYGFS AKSLQEFCSL PKSPLEEIEK
210 220 230 240
LEQLRALYQG KTIAMAVVQT QSVGIDTPQD YQRAIEHFKH Q
Length:241
Mass (Da):26,738
Last modified:October 1, 2003 - v1
Checksum:i8CBEBEFFD547DE26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP76765.1.
RefSeqiNP_859699.1. NC_004917.1.

Genome annotation databases

EnsemblBacteriaiAAP76765; AAP76765; HH_0168.
GeneIDi1493223.
KEGGihhe:HH0168.
PATRICi20587748. VBIHelHep90276_0165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017125 Genomic DNA. Translation: AAP76765.1.
RefSeqiNP_859699.1. NC_004917.1.

3D structure databases

ProteinModelPortaliQ7VJS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235279.HH0168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP76765; AAP76765; HH_0168.
GeneIDi1493223.
KEGGihhe:HH0168.
PATRICi20587748. VBIHelHep90276_0165.

Phylogenomic databases

KOiK00979.
OMAiNSGTERC.
OrthoDBiEOG6KT2SK.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00358; UER00476.
BioCyciHHEP235279:GHUA-172-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51449 / 3B1Imported.

Entry informationi

Entry nameiQ7VJS5_HELHP
AccessioniPrimary (citable) accession number: Q7VJS5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.